locomotor Flashcards
Osteoarthritis definition
- Result of mechanical and biological events that destabilise the normal process of degradation and synthesis of articular cartilage chondrocytes, extracellular matrix and subchondral
- Involves the entire joint, including the articular cartilage, subchondral bone, pericapsular muscles, capsule and synovium
- Condition leads to loss of cartilage, sclerosis and eburnation of subchondral bone, osteophytes and subchrondral cysts
how common is Osteoarthritis
• 8.5 million people in the UK have OA
causes of Osteoarthritis
- In the affected joint, there is a failure in maintaining the homeostatic balance of the cartilage matrix synthesis and degradation, resulting from reduced formation or increased catabolism
- Focal strss, trauma and eventual cartilage loss – this canfurther alter the joint anatomy, to predispose it even more to the potential detrimental effects of mechanical factors and physical activities, by redistributing and increasing the focal laoding in the joint
risk factors for Osteoarthritis
- Age >50 years
- Female
- Obesity
- Genetic factors
- Physical/manual occupation
- Knee malalignment
symptoms/signs of Osteoarthritis
- Presence of risk factors
- Pain
- Functional difficulties – knee giving away or locking, can be present
- Knee, hip, hand or spine involvement
- Bony deformities – MCPJs and involves the PIPJs and DIPJs – helps to distinguish it from RA
- Limited range of motion - both active and passive range of joint movement is reduced in moderate to advanced OA and this is usually associated with pain
- Malalignment – particularly in the knee where OA causes both gene valgum (knock-knees) and genu varum (bow-legs)
- Tenderness
- Crepitus
DDx of Osteoarthritis
- Gout
- Pseudogout
- RA
- Psoriaric arthritis
- Avascular necrosis (AVN)
- Internal derangements (e.g. meniscal tears)
Investigations of Osteoarthritis
• 1ST LINE:
- XR OF AFFECTED JOINTS: new bone formation (osteophytes), joint space narrowing, and subchondral sclerosis and cysts
- SERUM CRP: normal
- SERUM ESR: normal
Management of Osteoarthritis
• ACUTE:
- 1ST LINE: local analgesia e.g. capsaicin topical – apply to the affected areas three to four times daily
- 2nd LINE: paracetamol + local analgesia e.g. paracetamol + capsaicin topical
- 3rd LINE: NSAIDs + paracetamol + local analgesia e.g. paracetamol + naproxen + capsaicin
- 4th LINE: opioids + NSAIDs + paracetamol + local analgesia e.g. paracetamol + capasaicin + naproxen + oxycodone
• ONGOING:
- 1ST LINE: surgery
Prognosis and complications of Osteoarthritis
prognosis - Chronic slowly progressive disease and is almost ubiquitous with advancing age – no cure
complications - • Functional decline and inability to perform activities of daily living, spinal stenosis in cervical and lumbar OA, NSAID-related GI bleeding, effusion, NSAID-renal dysfunction
Gout definition
- Gout is a syndrome characterised hy: hyperuricaemia and deposition of urate crystals causing attacks of acute inflammatory arthritis, tophi around the joints and possible joint destruction, renal glomerular, tubular and interstitial disease and uric acid urolithiasis
- Most commonly affects the first toe, foot, ankle, knlee, fingers, wrist and elbow but can affect any joint
how common is Gout
- 1.6 per 1000 men and 0.3 per 1000 in owmen
* Mainly adults
causes of gout
- Uric acid is the end-product of the breakdown of purines (adenine and guanine), and exists as sodium urate in extracellular fluid
- Two-thirds of urate is excreted by the kidneys and a third by the GI tract. Hyperuricaemia is the single most important risk factor for developing gout
- The duration and magnitude of hyperuricaemia is directly correlated with the likelihood of subsequent development of gouty arthritis, uric acid kidney stones, and age of onset of clinical gouty manifestations
- However, gout can occur in people with normal plasma urate levels. Hyperuricaemia is usually due to impaired renal excretion of urate
- About 90% of people with hyperuricaemia are under excretors of urate, about 10% are over-producers, and some can be both
- Gout tends to attack joints in the extremities because temperatures in the feet and hands can be low enough to precipitate urate from plasma
- Thus tophi typically form in the helix of the ear, finger tips, olecranon bursae, and other cool anatomical sites
risk factors of gout
- Older age
- Male
- Menopausal status
- Consumption of meat, seafood, alcohol
- Use of diuretics, ciclosporin or tacrolimus, pyrazinamide and aspirin
- Genetic susceptibility
- High cell turnover state
symptoms of gout
- Presence of risk factors
- Rapid-onset severe pain
- Foot joint distribution
- Few affected joints
- Swelling and joint effusion
- Tenderness
- Tophi
- Erythema and warmth
DDx of gout
- Pseudogout (calcium pyrophosphate deposition disease)
- Septic arthritis
- Trauma
- RA
- Reactive arthritis and psoriatic arthritis
Investigations of gout
- 1st LINE: arthrocentesis with synovial fluid analysis WWC count >2/0 x10^9/L; strongly negative birefringent needle-shaped crystals under polarised light
- CONSIDER: uric acid level, x-ray of affected joint, ultrasound
Management of gout
• ACUTE:
- 1ST LINE – NSAID: naproxen
- 2nd LINE – colchicine used when NSAIDs and COX-2 inhibitors are contraindicated because of a Hx of GI bleeding or comorbidities e.g. asthma
- 3rd LINE – corticosteroid: prednisolone when 1st line and nd line are contraindicated e.g. in patients with renal insufficiency
• RECURRENT (2-3 WEEKS POST-ACUTE EPISODE):
- 1ST LINE: allopurinol (xanthine oxidase inhibitor)
- 2nd LINE: febuxostat (nonpurine selective xanthine oxidase inhibitor that reduces the production of uric acid)
- 3rd LINE: probenecid – if patient cannot tolerate allopurinol or febuxostat not effective in pts with renal insufficiency and could be used in combination with allopurinol
Prognosis and complications of gout
prognosis - good prognosis if managed well
complications - acute uric and nephropathy, nephrolithiasis
Septic arthritis definition
- Infection of 1 or more joints caused by pathogenic inoculation of microbes
- Occurs either by direct inoculation or via haematogenous spread
how common is septic arthritis
- 6 cases per 100,000
- mainly adults
causes of septic arthritis
- It results from the infection of the joint with pyogenic organisms, most commonly staphylococcus aureus
- In sexually active patients, gonococcal arthritis may be suspected
- Gram-negative organisms are more common in the elderly or immunosuppressed e.g. TB
- Joints become infected by direct injury or by blood borne infection from an infected skin lesion or other site
risk factors of septic arthritis
- Underlying joint disease
- Joint prostheses
- IV drug abuse
- Diabetes
- Presence of cutaneous ulcers