Breast Flashcards

1
Q

Abscess definition

A

• Local accumulation of pus within the breast due to infection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

how common is an abscess

A
  • 3-11% of women with mastitis, and about 10-33% of ladies lactating get mastitis
  • affects mainly lactating women
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

causes of an abscess

A

• Severe complication of mastitis, although it may occur without apparent preceding mastitis
• LACTATING WOMEN ¬– milk stasis is the primary cause of mastitis, milk stasis causes an inflammatory response that may or may not progress to an infection
• Most common organism is Staph Aureus or possible strains of MRSA
• NON-LACTATING – mastitis is usually accompanied by infection, which can be categorised as either central or subareolar or peripheral
- Central/Subareolar Infection – usually secondary to periductal mastitis or duct extasia
- Peripheral Non-Lactating Infection – has been associated with diabetes mellitus, rheumatoid arthritis, trauma, corticosteroid treatment, and granulomatous lobular mastitis but often there is no underlying cause

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

risk factors of an abscess

A
  • MASTITIS IN LACTATING WOMEN – poor infant attachement to the breast, reduced number or duration of feeds (e.g. partial bottle feeding, painful breasts, maternal stress and fatigue etc), no ebeidence that breast size is related, 30-34 years of age is the most likely time
  • MASTITIS IN NON-LACTATING WOMEN – smoking is the biggest, nipple damage (piercing, eczema infection, Raynaud’s), trauma, underlying breast abnormality, immunosuppression, shaving or plucking areolar hair, foreign body (implants)
  • BREAST ABSCESS – previous mastitis, sudden cessation of breastfeeding in women with lactational mastitis, staph aureus carriage, poor SES, poor hygiene
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

symptoms/signs of an abscess

A
  • History of recent mastitis
  • Fever or general malaise (these may have subsided if the women has taken antibiotics for suspected infectious mastitis)
  • Painful swollen lump in the breast, with redness, heat and swelling of the overlying skin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

DDx of an abscess

A
  • CONDITIONS THAT CAUSE BREAST PAIN AND ARE ASSOCIATED WITH LACTATION: full breasts, engorged breasts, a blocked duct, galactocele and infection of the mammary glands
  • CONDITIONS THAT CAUSE BREAST PAIN THAT ARE NOT ASSOCIATED WITH LACTATIO INCLUDE: breast cancer, duct ectasia, cellulitis, fibroadenosis, ruptured breast cyst, necrotising fasciitis of the breast, fat necrosis of the breast
  • CONDITIONS THAT CAUSE NIPPLE PAIN INCLUDE: poor infant attachment, candida infection of the nipple, blanching of the nipple, bacterial infection of the nipple, Raynaud’s disease of the nipple
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Investigations for an abscess

A
  • USS

* Culture fluid from abscess

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

management for an abscess

A
  • 1ST LINE  SURGICAL INTERVENTION – ultrasound-guided needle aspiration AND IV OR ORAL ANTIBIOTIC WITH ACTIVITY AGAINST METHICILLIN-SENSITIVE STAPHYLOCOCCI – dicloxacillin, cephalexin, doxcycline
  • Advise lactating women to continue breastfeeding if possible (including from the affected breast)
  • If this is too painful or the infant refuses the milk, express the milk either by hand or by pump until she is able to resume
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Fibrocystic Disease (Fibrocystic Breast Condition) definition

A
  • Fibrocystic breast disease AKA fibrocystic breasts or fibrocystic change
  • Benign condition in which the breasts feel lumpy
  • Fibrocystic breasts aren’t harmful or dangerous but may be bothersome or uncomfortable for some women
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

how common is Fibrocystic Disease (Fibrocystic Breast Condition)

A
  • 30-60% of women, 70-90% lifetime prevalence

* Women of childbearing age normally

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

causes for Fibrocystic Disease (Fibrocystic Breast Condition)

A

• Not fully understood, due to hormone levels (oestrogen, progesterone and prolactin) as the condition tends to subside after the menopause

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

risk factors for Fibrocystic Disease (Fibrocystic Breast Condition)

A
  • Age – 30-50

* Birth control pills may lower the likelihood but hormone therapy may increase them

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

symptoms for Fibrocystic Disease (Fibrocystic Breast Condition)

A
  • Non-cancerous breast lumps that can sometimes cause discomfort, often periodically related to hormonal influence from the menstrual cycle – diffuse symmetrical lumpiness through both breasts
  • May experience a persistent or intermittent breast aching or breast tenderness related to periodic swelling
  • Breast or nipples may be tender or itchy
  • Thickening of tissue
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

signs for Fibrocystic Disease (Fibrocystic Breast Condition)

A
  • Lumps are smooth with defined edges
  • Usually free moving in regards to surrounding tissue
  • Most often found in the upper, outer section of the breast
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

DDx for Fibrocystic Disease (Fibrocystic Breast Condition)

A

• Breast malignancy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Investigations for Fibrocystic Disease (Fibrocystic Breast Condition)

A

• 1st LINE  BREAST USS and MAMMOGRAPHY
• 2nd LINE
- SYMPTOMATIC BREAST CYSTS – cyst aspiration, fluid = straw-coloured and cyst drained  no need for cytological studies, fluid = bloody  cytology recommended
- SOLID MASSES ON PALPATION OR IMAGES (EVEN WHEN PALPABLE BUT NOT VISIBLE ON IMAGES) – breast biopsy to exclude malignancy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Management for Fibrocystic Disease (Fibrocystic Breast Condition)

A

• MASTALGIA:
- 1ST Line: reassurance through an explanation of the effects of menstrual hormonal cycling and oestrogen effects is effective in relieving patient anxiety, finding a bra that provides good support
o ADJUNCT: over the counter painkillers e.g. paracetomal (500-100mg every 4-6 hours) or ibuprofen (300-400mg every 6-8 hours) both when required
- 2ND Line: hormonal therapy  tamoxifen (primary), bromocriptine (secondary), danazol (tertiary)
• NIPPLE DISCHARGE:
- NON-SUSPICIOUS AND BREAST MASS NOT PRESENT  reassurance with observation
- NON-SUSPICIOUS AND BREAST MASS PRESENT  refer to oncologist
- SUSPICIOUS  referral and surgery

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Intraductal Papilloma (NOT CANCER) definition

A
  • Wart like lump that develops in one or more of the milk ducts in the breast
  • Usually close to the nipple but can be found anywhere in the body
19
Q

how common is Intraductal Papilloma (NOT CANCER)

A
  • 2-3% incidence

* Most common in women over 40 and usually develop naturally as the breast ages

20
Q

causes of Intraductal Papilloma (NOT CANCER)

A

• Can be associated with atypical hyperplasia – abnormal growth of cells

21
Q

risk factors for Intraductal Papilloma (NOT CANCER)

A
  • CENTRAL  develop near the nipple, generally in women nearing the menopause
  • PERIPHERAL  often multiple papilloma’s, younger women
22
Q

symptoms /signs of Intraductal Papilloma (NOT CANCER)

A
  • Bloody dischare
  • Aged 20-40
  • Generally do not show up on mammogram due ot their small size
  • Small lump on examination
  • Generally not painful but may have some pain or discomfort in that area

• Often too small to be palpated or felt

23
Q

DDx of Intraductal Papilloma (NOT CANCER)

A

• Malignancy

24
Q

Investigations for Intraductal Papilloma (NOT CANCER)

A

• 1st LINE:
- MAMMOGRAM – may be negative
- BREAST ULTRASOUND – dilated duct with oval mass
- BREAST DUCTOGRAM – filling defect of duct
• Other Investigations:
- BREAST BIOPSY – papillary growth pattern: benign papilloma or atypia, papillar ductal carcinoma in situ or invasive papillary carcinoma

25
Q

Management for Intraductal Papilloma (NOT CANCER)

A

• EXCISION – microdochectomy (removal of breast duct)

- Total Duct Excision – possibility, difficult to find all of the ducts

26
Q

Primary Invasive Breast Cancer definition

A
  • Malignancy originating in the breasts and nodal basins that may be classified into 3 stages which are defined by the extent of disease
  • Invasive indicates that the malignancy has penetrated pas the basement membrane o the duct or lobule of the breast and has spread to the surrounding areas
27
Q

how common is Primary Invasive Breast Cancer

A
  • Most common female malignancy – 1 in 10 new cancers diagnosed each year is breast cancer
  • Mainly women
28
Q

causes of Primary Invasive Breast Cancer

A

GENETIC FACTORS:
• Estimated cumulative incidence of breast cancer and ovarian cancer in BRCA mutuation carriers is 87% and 44%
• These mutations affect <0.1% of the general population, with variable penetrance

HORMONAL FACTORS;
• Oestrogen plays a role in the stimulation of mammary tumours

29
Q

risk factors for Primary Invasive Breast Cancer

A
  • Increasing age
  • Female
  • Caucasian
  • Generic disposition
  • Endogenous and exogenous oestrogen exposure
  • High levels of alcohol consumption
  • Radiation expsoure
  • Benign breast disease
  • High breast density
  • Weak: reduced physical activity, poor diet, smoking
30
Q

symptoms / signs for Primary Invasive Breast Cancer

A
  • Increased size of the mass – fibrocystic disease may fluctuate in size with menstrual cycle, but breast cancer progressively increases in size regardless of the menstrual cycle
  • Skin thickening or discolouration – peau d’orange, tethering
  • Axillary lymphadenopathy
  • Retraction or scaling of the nipple (may be related to Paget’s disease of the breast)
  • Nipple discharge
31
Q

DDx for Primary Invasive Breast Cancer

A
  • Fibrocystic changes
  • Fibroadenoma
  • Mastitis
32
Q

Investigations for Primary Invasive Breast Cancer

A

• 1ST LINE:
- MAMMOGRAM: initial screening test for asymptomatic patients (who are >40 years of age) and for symptomatic adult patients, if mammogram does not discover abnormality in pts who have a clinically detected breast mass  additional imaging USS/MRI needed
• CONSIDER: USS, MRI, biopsy, hormone receptor testing, HER2 receptor testing

33
Q

management for Primary Invasive Breast Cancer

A

• WOMEN AND MEN:

  • NODE-NEGATIVE, HER2 NEGATIVE, INVASIVE DUCTAL, LOBULAR, MIXED OR METAPLASTIC CARICNOMA: surgery (1st line) + chemo + radiotherapy
  • NODE-POSITIVE, HER2 NEGATIVE, INVASIVE DUCTAL, LOBULAR OR METAPLASTIIC CARCINOMA: surgery (1st line) + chemo (plus taxane-based chemo) + radiotherapy
  • NODE-POSITIVE OR NEG, HER2 POSITIVE, INVASIVE DUCTAL, LOBULAR OR METAPLASTIIC CARCINOMA: surgery (1st line) + trastuzumab-based chemo + radiotherapy
34
Q

prognosis and complications of Primary Invasive Breast Cancer

A

prognosis - case by case basis

complications - nausea, osteoporosis, vasomotor symptoms, lymphodema

35
Q

Breast Cancer In Situ definition

A
  • Cancer that is confined to the duct or lobule in which it originated and does not extend beyond the basemement membrane
  • Does not have acess to distant spread through lymphatics or the blood stream
36
Q

how common is Breast Cancer In Situ

A
  • 0.5-1% in men, 4% in women
  • Men and women
  • Higher incidence in caucasians
37
Q

causes of Breast Cancer In Situ

A
  • Proliferation of malignant appearing epithelial cells that have not penetrated the basement membrane
  • Terminal duct lobular unit is the origin of most lesions
38
Q

risk factors for Breast Cancer In Situ

A
  • Fx of breast cancer
  • Benign breast disease on prior biopsy
  • Herediary syndromes such as Li-Fraumeni syndrome, cowden’s syndrome or hereditary breast ovarian cancer syndrome
39
Q

symptoms/signs for Breast Cancer In Situ

A
  • Nipple discharge – unilateral discharge, whether bloody or not, may indicate benign tumour
  • Breast lump – smooth or nodular
  • Eczema-like rash on breast – bleeding from or excoriation of the nipple are typical presenting signs of paget’s disease of the breast
  • Ulceration – breast cancer that is ignored can present as an ulcerating skin lesion
40
Q

DDx for Breast Cancer In Situ

A
  • Locally invasive breast canceryst
  • Atypical hyperplasia
  • Fibroadenoma
  • Breast cyst
41
Q

Investigations for Breast Cancer In Situ

A

• 1st LINE:
- MAMMOGRAM: mammographic finding of clusterd calcifications, either focal or diffuse, and absence of a soft tissue abnormality, recommended especially in women >40, performed in younger women who have a family history of the disease or who present with a breast mass, unilater nipple discgarge or Paget’s disease
• CONSIDER: biopsy, stereotactic biopsy, sentinel node biopsy, USS-guided biopsy, MRI, ultrasonography, hormone receptor testing

42
Q

Management for Breast Cancer In Situ

A

• 1st LINE:

  • WOMEN <70 AND LOW VAN NUYS SCORE (<10): surgical excision +/- radiotherapy
  • WOMEN <70 WITH A HIGH VAN NUYS SCORE (>10): mastectomy +/- reconstruction, adjunct: radiotherapy
  • WOMEN >70: breast conservation surgery + radiotherapy
  • MEN: mastectomy
43
Q

Prognosis for Breast Cancer In Situ

A
  • Mastectomy carries the lowest risk of disease recurrence (2%)
  • 5 year survival is 98%
44
Q

Complications for Breast Cancer In Situ

A
  • Tamoxifen-related endometrial cancer

* Invasive breast cancer