Menstrual Disorders Flashcards
What is Amenorrhea?
Absence of menses
What is primary amenorrhea?
Absence of menarche (first menses) by age 15 despite normal growth and secondary sexual development
Absence of menarche by age 13 in absence of normal growth or secondary sexual development
What is Secondary amenorrhea?
Absence of menses for more than 3 months (previously regular cycles), or 6 months (previously irregular cycles) in women who were previously menstruating
Etiologies behind Primary Amenorrhea?
***Chromosomal abnormality causing gonadal dysgenesis (MOST COMMON)
Hypothalamic hypogonadism
Absence of the uterus, cervix and/or vagina, mullerian agenesis
Transverse vaginal septum or imperforate hymen
Pituitary disease
What happens in Tuner’s syndrome?
(45, XO)
Results in premature depletion of oocytes and follicles
Associated with short stature, widely spaced nipples, webbed neck, and sexual infantilism
What causes polycystic ovary syndrome
usually secondary amenorrhea
How does Hypogonadotrophic hypogonadism cause Primary Amenorrhea?
Dysfunction with:
- GnRH transport
- GnRH pulse discharge
- Congenital absence of GnRH
Disorders of HHP
slide 8
slide 9
9
How does Androgen Insensitivity Syndrome cause Primary Amenorrhea?
absent upper vagina, uterus and fallopian tubes on physical exam and pelvic ultrasound; high serum testosterone concentrations; and male (46,XY) karyotype
flow chart on slide 11
11
What is the first test you should order if someone comes in with supsected amenorrhea?
PREGNANCY
PRAGNANCY
PRAGNANCY