Menopause, Pelvic Organ Prolapse,Vaginal Bleeding, AUB Flashcards
Permanent cessation of menstruation due to loss of ovarian follicular activity
Menopause
12 months of amenorrhea after LMP with no attributable cause
Menopause
Years prior to menopause that encompasses the change from normal -> cessation of Menses
Perimenopaus
Hallmark of Perimenopause
Skipped periods or longer intervals (40-60) days
Period of time when a woman passes from reproductive stage to non reproductive stage
Climacteric
Mean menopausal age for Filipinos
48 yo
Mean perimenopausal age
45.1 y/o
Indirect measure of follicle reserve
Dec in inhibin
Principal steroid secreted by the ovary post menopause
Androstenedione
Hallmark of Female climacteric
Hot Flush/ Flash
Protective effects of Estrogen
Inc HDL
Dec Total Cholesterol including LDL
M/C Bone changes in Menopause
Vertebral Bone Fracture
Absolute contraindication for Hormone Replacement Therapy
Porphyria Cutanei tarda
Staging or Pelvic Organ Prolapse: No Descent
0
Staging or Pelvic Organ Prolapse: Leading point >1 cm above hymen
1
Staging or Pelvic Organ Prolapse: Leading point 1 cm above or 1 cm below the hymen
2
Staging or Pelvic Organ Prolapse: Leading point >1 cm below he hymen but less than TVL (-2)
3
Staging or Pelvic Organ Prolapse: Leading point is more than TVL (-2). Complete eversion
4
Management for Pelvic Organ Prolapse
Pelvic Floor Muscle Training
Pessary
Outgrow of distal edge of urethra
Due to chronic irritation or infection
Mostly on postmenopausal women
Urethral caruncle
Rare malformations of BVs
Single, 1-2 cm in diameter, flat, soft, brown/red
Hemangioma of Vulva
Originates in the apocrine sweat glands
Most on Labia majora (38%)
Hidradenoma
Secondary to blunt trauma
Spontaneous formation occurring during pregnancy or post partum
Hematoma
Toxic Shock Syndrome
Tampon use - Microulcerations
Most frequent cause of Local trauma to the vagina
Coitus
Risk Factors of Vaginal CA
History of Cervical CA
>5 partners
HPV Infection
Most common benign neoplastic growth of the Cervix
Polyp
Cherry red polyp
Endocervical polyps
Grayish white polyps
Grayish white
Most common type of cervical polyp
Adenomatous
Uterus AUB
PALM COEIN Polyp Adenomyosis Leiomyosis Malignancy
Coagulopathy Ovulatory Endometrial Iatrogenic Not yet classified
Localized overgrowths of endometrial glands and stroma that projects beyond endometrium
Endometrial polyps
3 components of Endometrial polyps
Endometrial Glands
Endometrial stroma
Central vascular changes
Mgt for Endoometrial polyps
Hysteroscopy with D&C
Ectopic endometrial glands and stroma within myometrium
Disruption of barrier between endometrium and myometrium
Adenomyosis: Endometriosis interna
Posterior wall mostly involved
Not encapsulated
Diffuse type
Asymmetric uterus
Pseudocapsule
Focal type
Definitive treatment for Adenomyosis
Hysterectomy
Single mutation in single progenitor cells which affects cytokine that affect cell growth which may be affected by estrogen and progesterone
Leiomyoma
Most common form and mildest form of leiomyoma
Hyaline
Most acute form of leiomyoma
Carnerous (red) degeneration
Classic indications for Myomectomy
Persistent AUB
Pain/Pressure
Asymptomatic mass >8cm
Contraindications for myomectomy
PAMP Pregnancy Advanced Adnexal Disease Malignancy Possible endometrial damage
Hysterectomy done in Leiomyoma
Asymptomatic with >14-16 weeks size
Menorrhagia + immediately after menarche or late 40s & 50s
Physiologic
Menorrhagia + soon after medication
Medication Induced
Menorrhagia + Weight gain or symptoms of hyperandrogenism
Anovulation
Menorrhagia + Gradual Increase over months, or sudden and non cylcic
Myoma, hyperplasia, malignancy
Menorrhagia + Increasing disability from systemic disease
Chronic
First line diagnostic tool for AUB
UTZ
accurate evaluation tool for intracavitary lesion
Saline Infusion Sonography
Endometrial biopsy indicated on:
Post menopausal woman with heavy irregular bleeding
Post menopausal women with Endometrial cells
Pre Menopausal women with atypical glandular cells
Tamoxifen patients with abnormal vaginal bleeding
Women still menstruating at age 52
AE: Danazol
Lowering of voice
Treatment of choice in women with hypovolemia due to DUB
D&C
Maybe offered as an initial treatment for HMB
Women with medical contraindication against hysterectomy
Women with normal uterus and those with small myoma < 3 cm
Endometrial Ablation
For failed pharmacological treatment
If HMB is causing anemia and/or serious impact to quality of life
Hysterectomy