Development of Bio;ogy of Sex Flashcards
Genetic Female sex is determined by
Absence of SRY gene
Definitive process for Sex Determination and Differentiation
Chromosomal or Genetic Sex
Determined at time of fertilization
Chromosomal or Genetic Sex
Single most consistent determinant of maleness
Presence of Y chomosomes
Does presence of additional X chromosome alter fundamental maleness?
No, as long as you have Y chromosome -> Male
Tests for Sex Determination
Sex Chromatin
Hair Root Test
Karyotyping
One of the two copies of the X chromosome present in Females is inactivated (Lyon Hypothesis)
Sex Chromatin Test
Sex Chromatin Test: 1 Barr body = 1 x chromosome
Normal Female
Sex Chromatin Test: 2 Barr bodies = 2 x chromosome
Superfemale
Florescent body (Y body) from hair strands Used in screening large population in Sports
Hair Root Test
Most accurate method of sexual determination
Indicated in:
Gender reassignment surgery
Ambiguous genitalia
Karyotyping
Development of primary sex organs in response to genetic sex
Gonadal Sex
Primitive gonad, outer cortex
Ovary
Primitive organ, inner medulla
Testes
AOG Formation of Leydig cells
8-9 weeks
AOG presence of definitive testes
9 weeks
AOG testes descends through inguinal ring
7-9 months
AOG maximal development of ovaries
20-25weeks
AOG developmental start of ovaries
9 weeks - in the absence of testes formation