MEN Flashcards
MEN 1 wermer syndrome
pituitary adenoma
PTH hyperplasia
Pancreatic tumors
MEN2A
PTH hyperplasia
Medullary thyroid carcinoma
Pheochromocytoma
MEN2B
mucosal neuromas
marfanoid body habitus
medullary thyroid carcinoma
pheochromocytoma
tumors of MEN syndromes are usually what
multifocal and arise in multiple organs
MEN tumors preceded by
asymptomatic stage of hyperplasia in cell of origin
what type of hyerplasia would you expect before medullary thyroid carcinoma
C cell hyperplasia in thyroid parenchyma
most common manifestation of MEN-1
primary hyperPTH
leading cause of morbidity and mortality in persons with MEN1
endocrine tumors of the pancreas
most common secreted product from pancreatic tumor in MEN 1
pancreatic polypeptide
most common ant pituitary tumor with MEN1
PRLoma
msot common site gastrinomas in individuals with MEN1
duodenum
mutation in MEN1
germline MEN1 tumor suppressor gene which encodes menin
dominant clinical manifestations MEN1
hypoglycemia,, pepetic ulcers, nephrolithiasis from PTH hyperCa and PRL excess Sx
3 classes of MEN2
2A 2B and familial medullary thyroid cancer
how do we detect medullary thyroid Ca
increased calcitonin levels
test for pheochromcytomas
increased urinary metanephrines
Mutation in sipple syndrome ( MEN2A
germline gain of function in RET proto-oncogene on chrom 10q11.2
which MEN syndrome has the more aggressive medullary thyroid carcinomas and pheos
MEN 2B
hyper PTH is not present in what MEN syndrome
2B
familial medullary thyroid cancer is a variant of what MEn syndrome
2A
individuals with RET mutations are advised to undergo what
prophylactic thyroidectomy to prevent formation of medullary carcinoma
