Memory Disorders Flashcards
week 4
what would happen to memory if there was damage to the hippocampus?
Poor episodic memory- personal history, memory for events
what would happen to memory if there was damage to the para-hippocampal cortex?
Poor semantic memory- general knowledge and the way the world works
what would happen to memory if there was damage to both the hippocampus and the para-hippocampal cortex?
Poor episodic/semantic memory
what are the causes of amnesia?
- Damage to different structures of the brain causes different amnesiac syndromes
○ Surgery
○ Chronic alcohol abuse
○ Brain tumours
○ Encephalitis
○ Bilateral stroke
○ Dementia
○ Closed head injury
what are the 3 main types of amnesia?
- Retrograde
- Anterograde
- Global
what is retrograde amnesia?
- Poor recall for memories formed before onset of amnesia
○ Greater for episodic than semantic memories
○ Greater recall of general knowledge
○ Poor for personal memory recall - Retro= past
- Temporal gradient (time, slope)
○ Before amnesia started, the percentage of recall for old memories is poorer than the memories remembered after the amnesia.
○ Childhood memories are in tact in comparison to memories occurring near the name of amnesia.
what is a temporal gradient?
the concept within retorgrade amnesia that sates memories before the onset of amnesia are forgotten but memories after the onset of amnesia are remembered.
what are the 3 main explanations of the temporal gradient?
- consolodation theory
- semanticisation
- reduced learning opportunity
what is consolodation theory?
○ Acquisition= learning new memories
○ Acquisition and consolidation require different structures
○ Physiological process in the hippocampus leads to formation of long-lasting memories
○ Consolidated memories stored elsewhere, protecting them from effects of hippocampal damage
* Protects the older memories from being forgotten.
what is semanticisation?
○ Episodic memories become more like semantic memories over time = protected from effects of brain-damage
○ Over time memories lose personal detail.
Become protected due to becoming more like semantic memories so are stored in a different area- protects them from brain damage.
what is reduced learning opportunity?
○ Episodic memories depend on a single learning experience = reduced learning opportunity explains amnesia
§ Lived experience of an event
○ Semantic memories depend on several learning experiences
§ More robust memory trace
* All combinations contribute to the temporal gradient.
what is anterograde amnesia?
- Loss of ability to form new memories after onset of amnesia= Impaired learning after amnesia
- Results from damage to the areas of the brain that are involved in forming new memories after the onset of amnesia.
- Damage to the hippocampus the main cause in most instances
Mammillary bodies and fornix also commonly involved
what is global amnesia?
- Moderate retrograde amnesia and severe anterograde amnesia
- A mix of both retrograde and anterograde amnesia
- Results from lesions of structures in the medial temporal lobe, specifically the hippocampus
○ Hippocampus= vital for the formation of new memories.
Patient HM
who is patentint HM and what is the significance with global amnesia?
- Most studied amnesiac patient
- Suffered from severe epilepsy from age of 10 years old
- At age of 27 years, surgery to remove entire medial temporal lobe
○ Drastic surgery - Moderate retrograde and severe anterograde amnesia
Epileptic seizures were relieved- they were lessened.
what is Korsakoff’s syndrome?
- Also known as diencephalic amnesia
- Most amnesic research looked at individuals who were alcoholics.
- Vitamin B1 deficiency from chronic alcoholism
Damage to mammillary bodies in hypothalamus - Memory impairment consists of the following:
○ Poor ability to remember events before and after onset of amnesia (retrograde/ anterograde)
§ Both forms of amnesia
○ Some new learning ability (e.g. motor skills)
Slight impairment of STM (e.g. digit span)