Memory Disorders Flashcards
week 4 (39 cards)
what would happen to memory if there was damage to the hippocampus?
Poor episodic memory- personal history, memory for events
what would happen to memory if there was damage to the para-hippocampal cortex?
Poor semantic memory- general knowledge and the way the world works
what would happen to memory if there was damage to both the hippocampus and the para-hippocampal cortex?
Poor episodic/semantic memory
what are the causes of amnesia?
- Damage to different structures of the brain causes different amnesiac syndromes
○ Surgery
○ Chronic alcohol abuse
○ Brain tumours
○ Encephalitis
○ Bilateral stroke
○ Dementia
○ Closed head injury
what are the 3 main types of amnesia?
- Retrograde
- Anterograde
- Global
what is retrograde amnesia?
- Poor recall for memories formed before onset of amnesia
○ Greater for episodic than semantic memories
○ Greater recall of general knowledge
○ Poor for personal memory recall - Retro= past
- Temporal gradient (time, slope)
○ Before amnesia started, the percentage of recall for old memories is poorer than the memories remembered after the amnesia.
○ Childhood memories are in tact in comparison to memories occurring near the name of amnesia.
what is a temporal gradient?
the concept within retorgrade amnesia that sates memories before the onset of amnesia are forgotten but memories after the onset of amnesia are remembered.
what are the 3 main explanations of the temporal gradient?
- consolodation theory
- semanticisation
- reduced learning opportunity
what is consolodation theory?
○ Acquisition= learning new memories
○ Acquisition and consolidation require different structures
○ Physiological process in the hippocampus leads to formation of long-lasting memories
○ Consolidated memories stored elsewhere, protecting them from effects of hippocampal damage
* Protects the older memories from being forgotten.
what is semanticisation?
○ Episodic memories become more like semantic memories over time = protected from effects of brain-damage
○ Over time memories lose personal detail.
Become protected due to becoming more like semantic memories so are stored in a different area- protects them from brain damage.
what is reduced learning opportunity?
○ Episodic memories depend on a single learning experience = reduced learning opportunity explains amnesia
§ Lived experience of an event
○ Semantic memories depend on several learning experiences
§ More robust memory trace
* All combinations contribute to the temporal gradient.
what is anterograde amnesia?
- Loss of ability to form new memories after onset of amnesia= Impaired learning after amnesia
- Results from damage to the areas of the brain that are involved in forming new memories after the onset of amnesia.
- Damage to the hippocampus the main cause in most instances
Mammillary bodies and fornix also commonly involved
what is global amnesia?
- Moderate retrograde amnesia and severe anterograde amnesia
- A mix of both retrograde and anterograde amnesia
- Results from lesions of structures in the medial temporal lobe, specifically the hippocampus
○ Hippocampus= vital for the formation of new memories.
Patient HM
who is patentint HM and what is the significance with global amnesia?
- Most studied amnesiac patient
- Suffered from severe epilepsy from age of 10 years old
- At age of 27 years, surgery to remove entire medial temporal lobe
○ Drastic surgery - Moderate retrograde and severe anterograde amnesia
Epileptic seizures were relieved- they were lessened.
what is Korsakoff’s syndrome?
- Also known as diencephalic amnesia
- Most amnesic research looked at individuals who were alcoholics.
- Vitamin B1 deficiency from chronic alcoholism
Damage to mammillary bodies in hypothalamus - Memory impairment consists of the following:
○ Poor ability to remember events before and after onset of amnesia (retrograde/ anterograde)
§ Both forms of amnesia
○ Some new learning ability (e.g. motor skills)
Slight impairment of STM (e.g. digit span)
what are the issues with the sympotomology of Korsakoff’s syndrome?
- typically has a grdual onset= events happen before or after the onset of amnesia
- brain damage widespread (hippocampus and frontal)= may lead to other functional/cognitive deficits
- precise pattern of damage varies across patients (difficult to determine the generalisability)
- brain plasticity and learing od compensatpry strategies= does ot provide a direct assessment of the impact of brain damage on LTM
what is semantic dementia?
- Severe problems with semantic memory, but intact episodic memory
- Presents itself as a language deficit.
○ Severe loss of information about meanings of words and concepts
○ Difficulty naming pictures/objects, single word comprehension, categorising, and knowing uses and features of objects. - Episodic memory and most executive functions (e.g. attention) reasonably intact in the early stages of semantic dementia
○ As it progresses, the damage to the brain widens out so overtime the semantic memories get lost. - Overtime, the brain regions affected spread, leads to decline in episodic memory as well as semantic memory.
- Patients differ in terms of precise symptoms
- Always involves degeneration of the anterior temporal lobe
– Where semantic memories are stored
– Perirhinal and entorhinal cortices where semantic memories formed
what is double dissociation?
Amnesia and semantic dementia point to a double dissociation in long-term memory
○ identify that brain damage to one structure disrupts one cognitive process (‘X’) but not another (‘Y’)
○ Also, identify that brain damage to different structure disrupts cognitive process ‘Y’ but not ‘X’
○ E.g.: one brain area influences semantic memory but not episodic memory
Another brain area influences episodic memory but not semantic memory.
wat is dissociation?
○ Identification of a brain region responsible for a cognitive process
One brain region is responsible for a brain process.
what is single-dissociation?
○ Identify that brain damage to one structure disrupts one cognitive process (‘X’) but not another (‘Y’)
Only one type of memory is affected- e.g.: semantic memory affected but not episodic memory.
what tpe of amnesia was experienced by Patient HM?
Global amnesia
What type of amnesia is characterised by poor recall for memories formed before onset of amnesia?
retrograde amnesia
What type of amnesia is characterised by a loss of ability to form new memories after amnesia onset?
Anterograde amnesia
what is eyewitness testimony?
- The accuracy of an individual’s memory is sometimes of enormous importance
○ You are the sole witness to a serious crime
○ You have to identify the perpetrator in a line-up: identification process
○ Your decision will be used as evidence
Help solve a case