Memory Flashcards
What does HM Have?
Priming, motor/skill learning, delay conditioning
What does HM NOT have?
Explicit recall, trace conditioning.
What is semantic memory?
Type of declarative, not episodic, knowing facts Ex: 2+2=4
How did Ray Kezner test memory
Rat in maze with food, then gives animal choice of where to be. Wanted to go back where food was.
Classical conditioning is part of
emotional memory
Short term
post-translational processing, quick but decays quicly, requires protein synthesis in gene expression
Long term
LTP, protein synthesis
____ is long term
____ is short term
Primacy (Long)
Recency (Short)
Rat hippocampal damage had normal
Skinnerian operant conditioning
Task 1: Visual Discrimination task in Y maze for hippocampal lesioned rats
Simultaneous- food always on black, can do
Successive - can’t do it; white go right, black go left
CAN”T DO SUCCESSIVE
Task 2: Morris’ Spatial and Cued Navigation Task
Place- can’t see platform
Cued- Can see platform
Lesioned can’t do place
Mark Rosen/Marian Dimon: Vary Rat conditions- what actually changed
Basal dendrite branching in 3rd, 4th, 5th, order
Short term mechanisms
synaptic transmitter changes (More NT, more receptive)
Interneuron modulation
(phosphorylation)
Long term mechanism
Forming new synapses/synaptic rearrangement
Perforant Path
EC to dentate gyrus
Mossy Fiber Path
Dentate gyrus to CA3 pyramidal cells
Schaffer Collaterals
CA3 pyramidal to CA1 pyramidal
Tim Bliss; Stimulated CA1 pyramidal neurons (whole “Baseline” thing. What did that prove?
Synaptic Specificity: The change is in one spot
LTP in CA1
- Glu release
- Na+ through AMPA after it binds
- If enough/repeated AMPA activation, Mg2+ out of channel
- Ca2+ ions enter which triggers LTP
- Activates Protein kinases and creb
- Retroactive messenger= more AMPA
Also CREB changes gene transcription
How does NMDA work as coincidence detector?
Mg+ block out and glutamate stimulation.
why must be paired in time
