Membranous Nephropathy Flashcards
—————the most common causes of nephrotic syndrome in adults, is a rare cause of nephrotic syndrome in children
Membranous Nephropathy
Which type of Membranous Nephropathy is common in childhood
In children, secondary MN is far more common than primary, idiopathic MN
The most cool etiology for secondary MN. ….?
The most common etiologies of secondary MN are systemic lupus erythematosus or chronic infections
What r the most common infections common etiology for MN ……?
chronic hepatitis B infection and congenital syphilis are the best characterized and recognized causes of MN
World wide most common cause for Nephrotic syndrome ,…….?
Malaria
Medications implicated in MN ……?
penicillamine and gold, or chronic factor replacement in patients with hemophilia can also cause MN
Pathology in MN…… .?
Glomeruli have diffuse thickening of the glomerular basement membrane (GBM), without significant cell proliferative changes.
Immunofluorescence and electron microscopy typically demonstrate granular deposits of immunoglobulin G and C3 located on the epithelial side of the GBM.
The GBM thickening presumably results from the production of membrane-like material in response to deposition of immune complexes
MN is believed to be caused …..?
In situ immune complex formation. T herefore, antigens from the infectious agents or medications associated with secondary MN directly contribute to the pathogenesis of the renal disease.
Pathophysiology of idiopathic or primary MN ….?
The causative antigen in idiopathic MN is not established, but the podocyte phospholipase A2 receptor, present on normal podocytes, may be a target antigen in idiopathic MN
Most common age at presentation of MN in childhood …?
In children, MN is most common in the second decade of life, but it can occur at any age, including infancy
The disease usually manifests as nephrotic syndrome and accounts for 2–6% of all cases of childhood nephrotic syndrome
Major venous thrombosis, commonly renal vein thrombosis. This complication of nephrotic syndrome is particularly common in patients with …..?
MN
Active carrier state for hepatitis B or congenital syphilis with nephrotic syndrome presentation in 2 decade of life the most likely etiology ….?
MN
Prognosis of MN ….?
children 1-15 yr after diagnosis, treated with a variety of regimens, indicate that 20% progress to chronic renal failure, 40% continue with active disease, and 40% achieve complete remission
Poor prognostic factors for MN …..?
male gender, high levels of proteinuria, reduced kidney function, and findings of glomerulosclerosis and tubular damage in the renal biopsy
