Immunoglobulin A Nephropathy (Berger Nephropathy

Question 1

A presentation with gross hematuria is common within 1-2 days after the onset of an apparent viral upper respiratory tract infection typical presentation of ….?

Answer 1

Immunoglobulin (Ig) A nephropathy

typically resolves within 5 days

Question 2

The most common chronic glomerular disease in children ….?

Answer 2

IgA nephropathy

Question 3

IgA nephropathy is characterized by …..?

Answer 3

A predominance of IgA within mesangial glomerular deposits in the absence of systemic disease

Question 4

Renal histology in IgA nephropath …..?

Answer 4

Renal histology demonstrates mesangial proliferation that may be associated with epithelial cell crescent formation and sclerosis.

IgA deposits in the mesangium are often accompanied by C3 complement

Question 5

IgA nephropathy is seen more often in male or female patient

Answer 5

Male

Question 6

Hypertensive emergency is it common in IgA nephropathy ….?

Answer 6

It’s usually un

common

Question 7

Single diagnostic test to differentiate between IgA and PSGN …… .

Answer 7

Normal serum levels of C3 in IgA nephropathy help to distinguish this disorder from postinfectious glomerulonephritis.

Serum IgA levels have no diagnostic value because they are elevated in only 15% of pediatric patients

Question 8

Common presentation of IgA nephropathy…?

Answer 8

A majority of children with IgA nephropathy in the United States and Europe present with gross hematuria,

whereas microscopic hematuria and/or proteinuria is a more common presentation in Japan

Question 9

Poor prognostic indicators IgA nephropathy….?

Answer 9

persistent hypertension,

diminished renal function, and

significant, increasing, or prolonged proteinuria

Question 10

More severe prognostic factors of IgA nephropathy…. .?

Answer 10

H istologic evidence of diffuse mesangial proliferation, extensive glomerular crescents, glomerulosclerosis, and diffuse tubulointerstitial changes, including inflammation and fibrosis

Question 11

Indication of corticosteroids in IgA nephropathy …?

Answer 11

If a renin-angiotensin system (RAS) blockade proves ineffective and significant proteinuria persists

Question 12

Role of tonsillectomy in treatment for IgA nephropathy ….?

Answer 12

Performing a tonsillectomy in the absence of significant tonsillitis in association with IgA nephropathy is currently not recommended until appropriate prospective, controlled trials have been performed and demonstrate efficacy