Membrane Potentials: Chapter 11 Flashcards
Action Potential
- electrical impulses that are carried along the entire length of axons
- always the same amplitude regardless of strength of stimulus
- CNS interpretation and response is impulse frequency based
Voltage
(V) measure of potential energy generated by separate charge (ie battery)
Potential difference
voltage measured between two points
Current
(I) the flow of electrical charge between two points
Resistance
(R) hindrance to charge flow
Insulator
substance with high electrical resistance
Conductor
substance with low energy resistance
What does the electrical current and the body reflect?
Flow of Ions (NOT ELECTRONS)
What is needed to have a potential of electrical flow through a membrane?
- the number of ions is different across the membranes
- the membrane provides resistance to ion flow
What is the importance of Ion channels?
It allows ions to pass through membranes
Passive or Leakage Channels
- always OPEN!
- Ions flow along the concentration gradient for the particular ion
- When gradient is equal on both sides then it will stop
Chemically Gated Channels:
-open with binding of a specific neurotransmitter or hormone
IE: NA+ -K+ gated channel
-Closed when a neurotransmitter/hormone is not bound to extracellular receptor
Voltage Gated Channels:
- open and close in response to a specific membrane potential… (- inside, + outside)
- IE: NA channel
- Closed when intracellular environment is negative (NA cannot enter, nor K exit cell)
- Open when a neurotransmitter is attached to receptor (NA enters, K exits)
Mechanically Gated Channels:
open & close in response to physical deformation of receptors (as in sensory receptors for touch & pressure)
-IE: Merkel cells deform in response to touch, opening NA channels
What happens when a gated channel is open?
- Ions move quickly across membrane
- movement along electrochemical gradients
- electrical currant is created
- voltage changes across membrane?