melanoma

Question 1

germline mutation in melanoma

Answer 1

Rarely, melanoma can arise in the context of a germline mutation in the oncogene BAP1, which is associated with the development of cutaneous and uveal melanomas, as well as other cancers including renal cell carcinoma and mesothelioma.

Question 2

work-up based on risk melanoma

Answer 2

SLN + then get CT (essentially stage 3 disease)

Question 3

Complete node dissection in melanoma

Answer 3

Not needed. Can do surveillance instead.

Question 4

if nodal basin recurrence only in melanoma then…

Answer 4

remove all lymph nodes in the basin

Question 5

BRAF inhibitor side effects

Answer 5

photosensitivity, arthralgias, SCC, GI side effects and fevers with MEK

Question 6

when to do radiation in melanoma

Answer 6

extra capsular extension

Question 7

Merkel cell carcinoma

Answer 7

rows rapidly and may be small, but 30% of cases have lymph nodes involved; therefore SLNB is recommended in all cases for staging.