Melanized (Dematiaceous) Fungi Flashcards

1
Q

Dark or black hyphae

A

Melanized

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2
Q

Reverse of colony is dark or black (front may vary)

A

Dematiaceous

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3
Q

Infection w/ black molds

A

Phaeohyphomycosis

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4
Q

Chronic subcutaneous skin condition w/ cauliflower-like growths; always caused by dematiaceous fungi

A

Chromomycosis/chromoblastomycosis

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5
Q

Chronic granulomatous infection; usually at the site of inoculation; swollen tissue w/ draining sinus tracts (grainy discharge); invasive into the bone

A

Mycetoma

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6
Q

Inflammation of the cornea of the eye caused by many different bacteria, yeast, molds, parasites

A

Keratitis

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7
Q

Mycetoma agent of infection by bacteria (GP bacilli); branching, filamentous

A

Actinomycotic

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8
Q

Agent of mycetoma by fungi; often dematiaceous fungi (BLACK granules); less often non-dematiaceous (WHITE granules)

A

Eumycotic

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9
Q

(“Copper pennies”) in tissue is diagnostic for chromoblastomycosis

A

Medlar/sclerotic/muriform bodies

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10
Q

Which genera are considered melanized (dematiaceous) fungi?

A
  • Fonsecaea
  • Phialophora
  • Cladosporium
  • Cladophialophora bantiana
  • Exophiala
  • Curvularia
  • Alternaria
  • Bipolaris
  • Stachybotrys
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11
Q

Most common organism that causes tinea nigra

A

Hortaea werneckii

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12
Q

Most common organism that causes black piedra

A

Piedraia hortae

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13
Q

Most common organism that causes chromoblastomycosis

A

Slow-growing fungi

  • Fonsecaea
  • Phialophora
  • Cladophialophora
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14
Q

Most common organism that causes white grain mycetoma

A

Pseudallescheria boydii, Fusarium, and others

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15
Q

Most common organism that causes black grain mycetoma

A

Exophiala and others

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16
Q

Most common organism that causes actinomycotic mycetoma

A
  • Partially acid-fast: Nocardia, Rhodococcus, and others

- Nonacid-fast: Streptomyces, Actinomadura

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17
Q

Most common organism that causes cerebral phaeohyphomycosis

A
Cladophialophora bantiana (leading cause in immunocompotent individual)
- Bacterial brain infections are MUCH more common
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18
Q

Clinical manifestations involved in tinea nigra

A
  • Dark patches on skin, usually palms of hands, soles of feet
  • Can resemble malignant melanoma
19
Q

Clinical manifestations involved in black piedra

A

Black nodules on hair (any body part)

20
Q

Clinical manifestations involved in chromomycosis

A
  • Cauliflower-like growths

- Sclerotic bodies (“copper pennies”) in tissue

21
Q

Clinical manifestations involved in mycetoma

A
  • Swollen tissue w/ draining sinus tracts (purulent, grainy discharge)
  • Sclerotia (also known as granules or grains) → color of grains can signify agent of infection (black vs. white)
22
Q

Clinical manifestations involved in cerebral phaeohyphomycosis

A

?

23
Q

Two dematiaceous fungi that are “rapid” growers

A
  • Curvularia

- Alternaria

24
Q

What is the criteria for “slow” growers and “rapid” growers?

A
  • Rapid: <7 days

- Slow: may take weeks to grow (10-14 days)

25
Q

How is man usually infected?

A

Accidentally infected from traumatic injury, inhalation in immunocompromised people (usually involve lower extremities)

26
Q

What is the gold standard for diagnosing melanized (dematiaceous) fungi?

A

Culture

27
Q

What are considered cutaneous (superficial) infections?

A
  • Tinea nigra
  • Black piedra
  • White piedra
28
Q

Subcutaneous infections are usually the result of a traumatic inoculation to the deep layers of the skin. What are two examples of this type of infection?

A
  • Chromoblastomycosis/chromomycosis

- Mycetoma

29
Q

Where are chromomycosis infections most commonly seen worldwide?

A

Tropic or subtropic climates (S. America) but cases have been seen in the U.S.

30
Q

What is diagnostic for chromoblastomycosis?

A

Sclerotic bodies (“copper pennies”) in tissue (aka medlar/muriform bodies)

31
Q

What is important to culture in a mycetoma?

A

Biopsy (culture the grains)

32
Q

Mycotic keratitis is often caused by what?

A

Traumatic injury, contact lens use, surgery

33
Q

Cladosporium vs. Cladophialophora

- Which one grows at 40°C?

A

Cladophialophora

34
Q

Cladosporium vs. Cladophialophora

- Which is a contaminant and which is pathogenic?

A
  • Cladosporium is a contaminant

- Cladophialophora is pathogenic (grows at body temp)

35
Q

Which dematiaceous fungi has four types of conidia growth?

A

Fonsecaea

  • Cladosporium
  • Acrotheca
  • Phialophora
  • Rhinocladiella
36
Q

Has flask-shaped phialides w/ flared collarettes

A

Phialophora

37
Q

Chains of elliptical conidia, branching conidiophores

A

Cladosporium

38
Q

Very long chains of conidia, very little branching

A

Cladophialora

39
Q

Pointed conidiophores w/ oval conidia that grow along the sides of the conidiophores

A

Exophiala

40
Q

Jagged conidiophores; conidia are 4-celled w/ swollen central cell (boomerang shaped, TRANSVERSE SEPTA ONLY)

A

Curvularia

41
Q

Drumstick/snowshoe macroconidia w/ LONGITUDINAL and TRANSVERSE SEPTA

A

Alternaria

42
Q

Twisted conidiophores where conidia are attached; conidia are oval and multicelled (“peapods”)

A

Bipolaris

43
Q

What is the major concern over molds causing “Sick Building Syndrome” (i.e., Stachybotrys)

A

It has an affinity for high cellulose (wallboard)

44
Q

What steps can be taken to prevent mold overgrowth in homes?

A
  • Use 1c bleach w/ 1 gallon water
  • Find/repair water leaks, air condition or dehumidifiers, ventilation in the bathrooms and kitchens, clean regularly, don’t carpet the bathrooms