Meiosis Flashcards
Meiosis
Takes place in the ovaries and testes only. And has 2 outcomes:
- Reduction Division: produces 4 daughter cells with half the number of chromosomes
- Recombination: products of meiosis have different combinations of genes.
Meiosis I
Reduction division (2n -> n) -separating homologous chromosomes (tetrads)
Meiosis II
Similar to Mitosis (n -> n)
-separating sister chromatids (splitting double-stranded chromosomes)
Synapsis
Homologous chromosomes find each other and pair up side by side so corresponding genes are aligned.
-occurs in Prophase I
Tetrad
2 chromosomes (4 chromatids) in homologous pair come together to form a tetrad.
Crossing Over
Chromatids intertwine during synapsis, sometimes intertwined chromatids from adjacent homologous chromosomes exchange segments of DNA.
= more genetic variation
Random Independent Assortment
Homologous chromosomes line up on equatorial plate with one chromosome from each pair positioned on either side of equatorial plate randomly.
-occurs in Metaphase I
Segregation
Homologous pairs separate and each homologue moves toward opposite poles of the cell.
=reduction division (2n ->n)
-occurs in Anaphase I
Gametogenesis in Females
Called “oogenesis”
- cytoplasm does not divide equally after each nuclear division
- 1 of 4 daughter cells, called the “ootid” receives most of the cytoplasm, other 3 are “polar bodies” with die and are absorbed by the body
- takes 28 days to produce
Gametogenesis in Males
Called “spermatogenesis”
- formation of sperm
- spermatocyte differentiate into spermatids
- equal division of cytoplasm
- 4 sperm cells are produced
Karyotypes
Organized profile of a person’s chromosomes
- arranged/numbered by size, largest to smallest
- helps scientists quickly identify chromosomal alterations that result in genetic disorder
- chromosomes stained to show banding
Nondisjunction
Chromosomes don’t separate properly
- one daughter cell will be LACKING genetic info and one will have TOO MUCH
- much more devastating in a gamete
- offspring with abnormal chromosome number are called aneuploidy
Trisomy 21
Down’s Syndrome (extra chromosome at chromosome #21)
-characteristic facial features, short stature, heart defects, respiratory infections, mental delays, sexually underdeveloped and sterile
Trisomy 13
Patau Syndrome (extra chromosome at chromosome #13) -serious eye, brain, and circulatory defects, as well as cleft plate
Trisomy 18
Edward’s Syndrome (extra chromosome at chromosome #18)
-almost every organ system affected