Megakaryocytopoiesis

Question 1

Write out thrombocytopoiesis

Answer 1

Pluripotential stem cell
Myeloid committed stem cell
BFU- MK
CFU-MK
Megakaryoblast
2N megakaryocte
4N
8N
16N
32N

Question 2

The megakaryoblast is often commonly confused or misidentified as a matured ________ in the bone marrow.

But because it can easily be stained for _____________________ it can easily be differentiated from

Answer 2

Lymphocyte

platelet- derived growth factor

Question 3

The ______ is the first morphologically identifiable megakaryocytic cell in the bone marrow.

Answer 3

megakaryoblast

Question 4

there is usually a failure of _______, such that the daughter would remain a binucleated single cell.

Answer 4

Telophase

Question 5

megakaryocytes mature by

Answer 5

endonuclear reduplication:

nucleus is duplicated without resulting in cell division

Question 6

The formation of platelets is usually from

Answer 6

fragmentation of the cytoplasm of megakaryocytes

Question 7

Function of platelets

Answer 7

The platelets function primarily to ensure formation of primary platelet plug when there is an injury to a blood vessel

Replace endothelial cells when denudation occurs by lining sub endothelial structure of blood vessels

Question 8

Mediating platelet adhesion is _____& ______

Answer 8

Glycoprotein 1b

Von willebrand factor

Question 9

Mediating platelet aggregation is

Answer 9

Glycoprotein 2A 3B

Question 10

Deficiency of 1B is

2A 3B is

Answer 10

Bernard-Soullier syndrome—loss of platelet adhesion.

Glanzmann dx, there will be failure of platelet aggregation.

Question 11

Haemostatic plug =

Answer 11

platelet plug + clot