B Cell Development Flashcards
Write out the process
Pluripotential stem cell
Lymphoid committed stem cell
Pre B cell (IGG rearrangement)
B cell in Transition
Virgin B cell (CD 19 20 21 22 23)
(Antigenic stimulation)
Small cleaved B cell
Large cleaved B cell
Small non-cleaved B cell
Large non-cleaved B cell
B immunoblast
Plasmacytoid cell
Plasma
Which immunoglobulins do these cells have
Pre B cell
B cell in transition
Circulating virgin B cell
Cytoplasmic immunoglobulin
Cytoplasmic & surface membrane immunoglobulin
Surface membrane immunoglobulin
The mechanism by which different B-cells have different surface membrane immunoglobulins is due to the phenomenon of ?
Gene rearrangement
The immunoglobulin molecule usually has ______& ______ chains.
two heavy and two light
The gene coding for the heavy chains is on chromosome
14
Two genes code for the light chains: The gene for Kappa chain is on chromosome __, and that for Lambda chain is on chromosome __?
Kappa 2
Lambda 22
heavy chain has 4 regions. They are?
constant, region
variable region
diversity region
joining regions
The typical immunoglobulin is a dimer except the______, which has the dimer in ____
immunoglobulin M
5 places (pentamer).
The genes present in all tissues of the body is the
Germ line inheritance
Germ line inheritance is rearranged in 2 types of cell in the body. This is
T cell
B cell
Gene rearrangement occurs in B lymphocytes to
Give the body the capacity to form antibodies to any type of antigen found in nature
How do you identify the Pre -B cell
Staining: presence of immunoglobulin in the cytoplasm
Gene rearrangement
From ________ to _______ express common receptors which are
B cell in transition
Last stage
CD 19, 20, 21, 22
Activated B cell expresses receptors ?
CD19 20 21 22 23
The further development of virgin B cell depends on
Antigenic stimulation
When antigenic stimulation occurs, further development of virgin B cell occurs in
Lymph node : Follicular center
Which part of the lymph node homes T cell
Paracortex
What levels of development occurs in lymph node
Virgin B cell (CD 19 20 21 22 23)
(Antigenic stimulation)
Small cleaved B cell
Large cleaved B cell
Small non-cleaved B cell
Large non-cleaved B cell
B immunoblast
Back to the bone marrow, what development takes place
B immunoblast
Plasmacytoid cell
Plasma cell
The period between exposure to a given and development of an antibody is known as
Serologic Latency Period
Window period
What is a memory B cell
This is a virgin B cell that had previously matured into B immunoblast stage
Time taken from antigenic stimulation to plasma cell is
14 days /2 weeks
Memory phenomenon occurs to ?
Shortejbimmunologicak rxn time to 3-4 days
Functions of B cell
production of the immunoglobulins
Mediate humoral immunity
Works in opsonization
If the B-cell will be transformed into a malignancy, it could be ____ or _____
solid/circulating
The malignancies from ____, ______, _______& _______ become circulating malignancies, which becomes leukaemias.
LCSC, pre-B cell, BT, and virgin B-cells
If the antigenically-stimulated B-cell will acquire malignancy, they transform into _________, since they are already in the lymph nodes.
Lymphoma (solid)
• Circulating neoplasia of the hematiopoietic cells is known as
• Malignancy of the virgin B-cells is known as
• Malignancy of the LCSC, pre-B cell, and the BT is known as
Leukemia
Chronic leukemia
Acute leukemia
The B-cell undergoes ___,______&_____ to become plasma cell.
antigenic stimulation, clonal expansion, and maturation
Most animals/individuals will require at least ________ to produce sufficient amount of immunoglobulin to the vaccinating immunogens.
12 weeks
