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FPP Hemat > B Cell Development > Flashcards

B Cell Development Flashcards

1
Q

Write out the process

A

Pluripotential stem cell
Lymphoid committed stem cell
Pre B cell (IGG rearrangement)
B cell in Transition
Virgin B cell (CD 19 20 21 22 23)
(Antigenic stimulation)
Small cleaved B cell
Large cleaved B cell
Small non-cleaved B cell
Large non-cleaved B cell
B immunoblast
Plasmacytoid cell
Plasma

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2
Q

Which immunoglobulins do these cells have

Pre B cell
B cell in transition
Circulating virgin B cell

A

Cytoplasmic immunoglobulin

Cytoplasmic & surface membrane immunoglobulin

Surface membrane immunoglobulin

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3
Q

The mechanism by which different B-cells have different surface membrane immunoglobulins is due to the phenomenon of ?

A

Gene rearrangement

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4
Q

The immunoglobulin molecule usually has ______& ______ chains.

A

two heavy and two light

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5
Q

The gene coding for the heavy chains is on chromosome

A

14

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6
Q

Two genes code for the light chains: The gene for Kappa chain is on chromosome __, and that for Lambda chain is on chromosome __?

A

Kappa 2

Lambda 22

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7
Q

heavy chain has 4 regions. They are?

A

constant, region
variable region
diversity region
joining regions

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8
Q

The typical immunoglobulin is a dimer except the______, which has the dimer in ____

A

immunoglobulin M

5 places (pentamer).

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9
Q

The genes present in all tissues of the body is the

A

Germ line inheritance

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10
Q

Germ line inheritance is rearranged in 2 types of cell in the body. This is

A

T cell
B cell

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11
Q

Gene rearrangement occurs in B lymphocytes to

A

Give the body the capacity to form antibodies to any type of antigen found in nature

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12
Q

How do you identify the Pre -B cell

A

Staining: presence of immunoglobulin in the cytoplasm

Gene rearrangement

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13
Q

From ________ to _______ express common receptors which are

A

B cell in transition
Last stage

CD 19, 20, 21, 22

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14
Q

Activated B cell expresses receptors ?

A

CD19 20 21 22 23

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15
Q

The further development of virgin B cell depends on

A

Antigenic stimulation

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16
Q

When antigenic stimulation occurs, further development of virgin B cell occurs in

A

Lymph node : Follicular center

17
Q

Which part of the lymph node homes T cell

A

Paracortex

18
Q

What levels of development occurs in lymph node

A

Virgin B cell (CD 19 20 21 22 23)
(Antigenic stimulation)
Small cleaved B cell
Large cleaved B cell
Small non-cleaved B cell
Large non-cleaved B cell
B immunoblast

19
Q

Back to the bone marrow, what development takes place

A

B immunoblast
Plasmacytoid cell
Plasma cell

20
Q

The period between exposure to a given and development of an antibody is known as

A

Serologic Latency Period

Window period

21
Q

What is a memory B cell

A

This is a virgin B cell that had previously matured into B immunoblast stage

22
Q

Time taken from antigenic stimulation to plasma cell is

A

14 days /2 weeks

23
Q

Memory phenomenon occurs to ?

A

Shortejbimmunologicak rxn time to 3-4 days

24
Q

Functions of B cell

A

production of the immunoglobulins
Mediate humoral immunity
Works in opsonization

25
Q

If the B-cell will be transformed into a malignancy, it could be ____ or _____

A

solid/circulating

26
Q

The malignancies from ____, ______, _______& _______ become circulating malignancies, which becomes leukaemias.

A

LCSC, pre-B cell, BT, and virgin B-cells

27
Q

If the antigenically-stimulated B-cell will acquire malignancy, they transform into _________, since they are already in the lymph nodes.

A

Lymphoma (solid)

28
Q

• Circulating neoplasia of the hematiopoietic cells is known as
• Malignancy of the virgin B-cells is known as
• Malignancy of the LCSC, pre-B cell, and the BT is known as

A

Leukemia

Chronic leukemia

Acute leukemia

29
Q

The B-cell undergoes ___,______&_____ to become plasma cell.

A

antigenic stimulation, clonal expansion, and maturation

30
Q

Most animals/individuals will require at least ________ to produce sufficient amount of immunoglobulin to the vaccinating immunogens.

A

12 weeks

FPP Hemat (8 decks)

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