MEDS II-MOOD DISORDERS

Question 1

– Lithium
– Depakote
– Lamictal
– Tegretol
– Trileptal
– Topamax

Answer 1

Mood Stabilizers for depression

Question 2

– Risperdal
– Zyprexa
– Seroquel
– Geodon
– Abilify
– Invega

Answer 2

Antipsychotics for depression

Question 3

– Effective but cause multiple side effects
– Can be very sedating
– Cardiotoxic and lethal in overdose

Examples – Elavil, Doxepin

Answer 3

TCA’s

Question 4

– Risk of Serotonin Syndrome
– Risk of Hypertensive Crisis
– Special diet required
– Most effective for atypical or treatment
resistant depression

Examples – Nardil, Parnate

Answer 4

MAOI’s

Question 5

• Treatment of manic episodes
• Inexpensive
• Decreases suicidality
• Narrow therapeutic window
• Toxic at high levels
• Long term side effects
• Risky in pregnancy Æ heart defect

Answer 5

Lithium

Question 6

• Treatment of manic episodes
• Side effects include weight gain and sedation
• Processed through the liver
• Severe birth defects – anencephaly, spina bifida, facial deformities

Answer 6

Depakote (Valproic Acid)

Question 7

• Indicated for Bipolar Depression and
maintenance treatment of Bipolar Disorder
• Stevens Johnson Syndrome – black box
warning
• Takes a long time to titrate up to a therapeutic dose

Answer 7

Lamictal (Lamotrigine)

Question 8

• No FDA indication for use in Bipolar Disorder
• Cannot be used with oral contraceptives
• Many other drug interactions
• Aplastic Anemia – serious side effect

Answer 8

Tegretol (Carbamazepine)

Question 9

• No FDA indication for use in Bipolar
Disorder
• Chemical structure related to Tegretol
• Less risk of aplastic anemia
• May cause low sodium level

Answer 9

Trileptal (Oxcarbazepine)

Question 10

• No FDA indication for Bipolar – questionable efficacy
• Some weight loss associated with use
• Common side effect –cognitive impairment

Answer 10

Topamax (Topiramate)