Medication Formulary Flashcards
Amiodarone Class
Antiarrhythmic Agent
Amiodarone Description
Class III Antiarrhythmic agent used to treat ventricular arrhythmias
Amiodarone Presentation
150mg in 3ml solutionPre-filled Syringes 10ml (30 mg/ml)
Amiodarone Administration
Inreavenously (IV)Intraosseous (IO)
Amiodarone Indications
Ventricular Fibrillation andPulseless Ventricular Tachycardia
Amiodarone Contraindications
KSARKnown Hypersensitivity To Iodine
Amiodarone Dosages
Adult: 5mg/Kg IV/IO (Loading dose in Cardiac Arrest 300mg and supplemental dose of 50mgPaed: 5mg/Kg
Amiodarone Pharmacology
AntiarrhythmicProlongs the action potentialProlongs the refractory periodProlongs atrioventricular conductionProlongs QT Interval
Amiodarone Side Effects
Inflammation of peripheral veinsBradycardiaAV conducting abnormalities
Amiodarone Additional Info
If diluted mix with Dextrose 5%May be flushed with NaCl
Aspirin Class
Platelet Aggregator Inhibitor
Aspirin Description
Anti-inflammatory agent and an inhibitor of platelet function.Useful agent in the treatment of various thromboembolic diseases such as acute myocardial infarction
Aspirin Presentation
3000mg soluble tablet
Aspirin Administration
Orally (PO) - if soluble, disperse in water. if non soluble, to be chewed.
Aspirin Indications
Cardiac chest pain or suspected myocardial infarction
Aspirin Contraindications
Active symptomatic gastro-intestinal ulcerBleeding disorder (e.g. Haemophilia)KSARPatients < 16 yrs old
Aspirin Dosages
Adult: 300mgPaed: not indicated
Aspirin Pharmacology
AntithromboticInhibits the formation of thromboxane A2, which stimulates platelet aggregation and artery constriction.This reduces clot/thrombus formation in an MI
Aspirin Side Effects
Epigastric pain and discomfortBronchospasmGastrointestinal Haemorrhage
Aspirin Additional Info
Aspirin 300mg is indicated for cardiac chest pain regardlessif patient is on anti-coagulants or is already on aspirin.If the patient has swallowed an aspirin (enteric coated) preparation without chewing it, the patient should be regarded as not having taken any aspirin; Administer Aspirin 300mg PO.
Atropine Class
Anticholinergic
Atropine Description
Parasympatholytic that is derived from the Atropa Belladonna plant
Atropine Presentation
Pre-filled syringe 1mg/10mlAmpoule 0.6mg in 1ml
Atropine Administration
Intravenous (IV)Intraosseous (IO)
Atropine Indications
Symptomatic BradycardiaOrganophosphate Poisoning
Atropine Contraindications
KSAR
Atropine Dosage
Organophosphate Poisoning - 1mg IV, Repeat at 3-5min intervals to ensure minimal salivary secretions.Symptomatic Bradycardia - 0.5mg IV. Repeat at 3-5min intervals to max 3mg.
Atropine Pharmacology
Anticholinergic agentBlocks acetylcholine receptors-enhances SA node automaticity-enhances AV node conduction-increases heart rate
Atropine Side Effects
TachycardiaDry MouthDilated Pupils
Atropine Additional Info
Accidental exposure to the eye causes blurred vision
Benzylpenicillin Class
Antibiotic, antibacterial
Benzylpenicillin Descriptions
Benzylpenicillin is an antibiotic agent
Benzylpenicillin Presentation
Intravenous (IV) or Intraosseous (IO).May give by IM injection if no IV access.IV/IO - Reconstitute each 600mg vial with 4ml of water for injection and give by slow IV injection over 3-5mins.IM - Reconstitute each 600mg vial with 2ml of water for injection
Benzylpenicillin Administration
Intravenous (IV)Intrados serous (IO)
Benzylpenicillin Indications
Suspected or confirmed Meningococcal Sepsis
Benzylpenicillin Contraindications
KSAR
Benzylpenicillin Dosage
Adult - 1200mg IV, IO or IMPaed - > 8 yrs - 1200mg1-8 yrs - 600mg< 1 yr - 300mg
Benzylpenicillin Pharmacology
AntibacterialGram positive cocci antibiotic
Benzylpenicillin Side Effects
Gastro-intestinal disturbancesHypersensitivity rections
Benzylpenicillin Additional Info
Also called Penicillin G
Clopidogrel Class
Platelet aggregator inhibitor
Clopidogrel Description
An inhibitor of platelet function
Clopidogrel Administration
Orally (PO)
Clopidogrel Indications
Identification of ST Elevation Myocardial Infarction (STEMI)
Clopidogrel Contraindications
KSARActive Pathological BleedingSevere Liver Impairment
Clopidogrel Doseage
600mg PO> 75yrs 75mg PO
Clopidogrel Pharmacology
Clopidogrel selectivelyinhibits the binding of adenosine diphosphate (ADP) to its platelet receptor, and the subsequent ADP - mediated activation of the GPIIb/IIIa complex, thereby inhibiting platelet aggregation.Biotransformation of clopidogrel is necessary to produce inhibition of platelet aggregation. Clopidogrel acts by irreversibly modifying the platelet ADP receptor
Clopidogrel Side Effects
Abdominal PainDyspepsiaDiarrhoea
Clopidogrel Additional Info
Paramedics are authorised to administer Clopidogrel PO following identification of STEMI and medical practitioner instruction
Cyclizine Class
Anti-emetic
Cyclizine Descriptions
Used in management of nausea and vomiting
CyclizinePresentation
Ampoule 50mg in 1ml
Cyclizine Administration
Intravenous (IV)Intraosseous (IO)
Cyclizine Indications
Management, prevention and treatment of nausea and vomiting
Cyclizine Contraindications
KSAR
Cyclizine Dosage
Adult - 50mg IV/IOPaed - not indicated
Cyclizine Pharmacology
Anti-emetic
Cyclizine Side Effects
TachycardiaDry MouthSedation
Cyclizine Additional Info
IM route should only be utilised where IV or IO access is not available
Dextrose 10% Solution Class
Carbohydrate
Dextrose 10% Solution Description
Dextrose is used to describe the six-carbon sugar d-glucose, which is the principal form of carbohydrate used by the body.D10W is a hypertonic solution
Dextrose 10% Solution Presentation
Soft pack for infusion 250ml and 500ml
Dextrose 10% Solution Administration
Intravenous (IV)Intraosseous (IO)
Dextrose 10% SolutionIndications
Hypoglycaemic emergencyBlood glucose level < 4 mmol/L
Dextrose 10% Solution Contraindications
KSAR
Dextrose 10% Solution Doseage
Adult - 250ml IV/IORepeat X 1 prnPaed - 5ml/KgRepeat X 1 prn
Dextrose 10% Solution Pharmacology
Hypertonic glucose solutionReadily utilisable energy sourse
Dextrose 10% Solution Side Effects
Necrosis of tissue around IV access
Dextrose 10% Solution Additional Info
Also called GlucoseCannula patency will reduce the effect of tissue necrosis
Epinephrine 1:10,000Class
Sympathetic Agonist
Epinephrine 1:10,000Description
Naturally occurring catecholamine. It is a potent alpha and beta adrenergic stimulant; however, its effect on beta-receptors is more profound
Epinephrine 1:10,000Presentation
Pre-filled syringe 1mg/10ml (1:10,000) as 0.1mg/ml
Epinephrine 1:10,000Administration
Intravenous (IV)Intraosseous (IO)
Epinephrine 1:10,000Indications
Cardiac ArrestPaediatric Symptomatic Bradycardia unresponsive to other measures
Epinephrine 1:10,000Contraindications
KASR
Epinephrine 1:10,000Dosage
Adult: Cardiac Arrest 1mg (1:10,000)Repeat every 3-5 minsPaed:Cardiac Arrest 0.01mg/kg (0.1ml/mg) (1:10,000)Repeat every 3-5 minsBradycardia 0.01mg/kg (0.1ml/mg) (1:10,000)Repeat every 3-5 mins
Epinephrine 1:10,000Pharmacology
Alpha and beta adrenergic stimulantIncreases heart rate - Chronotropic effectIncreases Myocardial contractions - inotropic effectIncreases Blood PressureIncreases electrical activity in the myocardiumincreases cerebral and coronary blood flowDilation of the bronchioles
Epinephrine 1:10,000Side Effects
In non cardiac arrest patients-Palpatationa-Tachyarrhythmias-Hypertension
Epinephrine 1:10,000Additional Info
N.B. Double check concentrations before use
Epinephrine 1:1,000Class
Sympathetic Agonist
Epinephrine 1:1,000Description
Naturally occurring catecholamine. It is a potent alpha and beta adrenergic stimulant; however, its effect on beta-receptors is more profound
Epinephrine 1:1,000Presentation
Pre-filled syringe, ampoule or auto injector1mg/ml (1:1,000)
Epinephrine 1:1,000Administration
Intramuscular (IM)
Epinephrine 1:1,000Indications
Severe Anaphylaxis
Epinephrine 1:1,000Contraindications
None known
Epinephrine 1:1,000Dosages
Adult:0.5mg (500mcg) (1:1,000) IMRepeat every 3-5 mins if indicatedPaed:8yrs - 0.5mg (500mcg) (.05ml)repeat every 3-5 mins if indicated
Epinephrine 1:1,000Pharmacology
Alpha and beta adrenergic stimulant.Reversal of laryngeal oedema and bronchospasm in anaphylaxis.Antagonises effects of histamine
Epinephrine 1:1,000Side Effects
PalpitationsAngina like symptomsTachyarrhythmiasHypertension
Epinephrine 1:1,000Additional Info
N.B. Double check the concentration on pack before use
FurosemideClass
Diuretic
FurosemideDescription
A loop diuretic
FurosemidePresentation
10mg per mL2ml, 5ml, 25ml Ampoule
FurosemideAdministration
Intravenous (IV)
FurosemideIndication
Pulmonary Oedema
FurosemideContraindications
PregnancyHypokalaemiaKSAR
FurosemideDosage
Adult: 40mg IVPaed: not indicated
FurosemidePharmacology
Acts on the ascending loop of Henle by inhibiting the reabsorption of Chloride and Sodium ions into the interstitial fluid. This results in a relative hypertonic state. Water is retained in the loop and eliminated via the bladder.It also causes venodilation which reduces venous return to the heart
FurosemideSide Effects
HeadacheDizzinessHypotensionArrhythmiasTransient deafnessDiarrhoeaNausea Vomiting
Furosemide Additional Info
Furosemide should be protected from light
GlucagonClass
Hormone and Anti-hypoglycaemic
GlucagonDescription
Glucagon is a protein secreted by the alpha cells of the Islets of Langerhans in the pancreas. It is used to increase the blood glucose level in cases of hypoglycaemia in which an IV cannot by immediately be placed
GlucagonPresentation
1mg vial powder for reconstitution (1ml)
GlucagonAdministration
Intramuscular (IM)
GlucagonIndications
Hypoglycaemia in patients unable to take oral glucose or unable to gain IV access with a blood glucose level <4mmol/L
GlucagonContraindications
KSARPhaeochromocytoma
GlucagonDosage
Adult: 1mg IMPaed: ≤ 8yrs 0.5mg IM> 8yrs 1mg IM
GlucagonPharmacology
Glycogenolysis.Increases plasma glucose by mobilising glycogen stored in the liver
GlucagonSide Effects
Rare: may cause Hypotension, dizziness, headache, nausea & Vomiting
GlucagonAdditional Info
May be ineffective in patients with low stored glycogen e.g. prior use in previous 24 hours, alcoholic patients with liver disease.Protect from light
Glucose GelClass
Anti-hypoglycaemic
Glucose GelDescription
Synthetic glucose paste
Glucose GelPresentation
Glucose gel in a tube or sachet
Glucose GelAdministration
Buccal Administration (BU)Administer gel to the inside of the patient’s cheek and gently massage the outside of the cheek
Glucose GelIndications
HypoglycaemiaBlood glucose <4 mmol/L
Glucose GelContraindications
KSAR
Glucose GelDosages
Adult: 10 - 20g buccalPaed: ≤ 8yrs: 5 - 10g buccal> 8yrs: 10 - 20g buccal
Glucose GelPharmacology
Increases blood glucose levels
Glucose GelSide Effects
May cause vomiting in patients under the age of five if administered too quickly
Glucose GelAdditional Info
Glucose gel will maintain glucose levels once raised but should be used secondary to Dextrose or Glucagon to reverse hypoglycaemia.Proceed with caution:- patients with airway compromise-altered level of consciousness
EnoxaparinClass
Anticoagulant
EnoxaparinDescription
Enoxaparin is a Low Molecular Weight Heparin used in conjunction with a thrombolytic agent for the treatment of STEMI
EnoxaparinPresentation
Prefilled syringes (100mg/mL)
EnoxaparinAdministration
Intravenous (IV)
EnoxaparinIndications
Acute STEMI immediately following the administration of a thrombolytic agent
EnoxaparinContraindications
Active major bleeding disorders and conditions with a high risk of uncontrolled haemorrhage, including recent haemorrhagic stroke or subdural haematoma; in jaundice; active gastric or duodenal ulceration; hiatal ulceration; threatened abortion, or retinopathy.Hypersensitivity to Enoxaparin or other LMWH.KSAR
EnoxaparinDosage
Adult: 30mg IV BolusPaed: not indicated
EnoxaparinPharmacology
It binds to the natural inhibitor of coagulation, anti-thrombin III and makes certain clotting factors inactive. This results in an increase in the clotting time
EnoxaparinSide Effects
Pain, Haematoma and mild local irritation may follow the subcutaneous injection
EnoxaparinAdditional Info
Do not store above 25°CDo not refrigerate or freeze.
GTNClass
Nitrate
GTNDescription
Special preparation of Glyceryl Trinitrate in an aerosol form that delivers precisely 0.4mg of GTN per spray
GTNPresentation
Aerosol spray: metered dose 0.4mg (400mcg)
GTNAdministration
Sublingual (SL)
GTNIndications
AnginaSuspected Myocardial Infarction (MI)Pulmonary Oedema
GTNContraindications
Sys BP <90 mmHgViagra or other Phosphodiesterase type 5 inhibitors (sildenafil,taladafil, vardenafil) used within previous 24 hoursKSAR
GTNDosage
Adult:Angina or MI: 0.4mg repeat at 3-5 mins to max 1.2mgPulmonary Oedema: 0.8mg Repeat X 1Paed: not indicated
GTNPharmacology
VasodilatorReleases nitric oxide which acts as a vasodilator. Dilates coronary arteries particularly if in spasm, increasing blood flow to the myocardium.Dilates systemic veins reducing venous return to the heart (preload) and thus reduces the heart workload.Reduces BP.
GTNSide Effects
HeadacheTransient HypotensionFlushingDizziness
GTNAdditional Info
If the pump is new or has not been used for a week or more the first spray should be released into the air