medical problems in pregnancy Flashcards

1
Q

common symptoms of pregnancy

A

nausea and vomiting in early pregnancy

heartburn

constipation

haemorrhoids

vaginal discharge

backaches

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2
Q

when should nausea and vomiting resolve and what advise should be given to women

A

resolve spontaneously within 16-20 weeks

should not be associated with a poor pregnancy outcome

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3
Q

what treatment can be offered to women who wants to reduce their nausea and vomiting symptoms

A
non‑pharmacological:
---- ginger
---- P6 (wrist) acupressure
---- eating small but frequent meals
---- avoiding triggers
---- having lots to drink
rest

pharmacological:
—- antihistamines - prometazine, cyclizine or prochlorperazine

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4
Q

what advise to give pregnant women complaining about constipation

A

increase water content

diet modification - bran or wheat fibre supplementation

exercise

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5
Q

advise about varicose veins

A

common symptom of pregnancy that will not cause harm and that compression stockings can improve the symptoms but will not prevent varicose veins from emerging.

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6
Q

whst Sx of vaginal discharge might prompt Ix

A

tch, soreness, offensive smell or pain on passing urine

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7
Q

advise for backache during pregnancy

A

exercising in water, massage therapy and group or individual back care classes

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8
Q

what is hyperemesis gravidarum

ass with

A

the sickness and vomiting are prolonged and very severe.

lacking in fluid in the body (dehydrated) and to lose weight.

vitamin deficiencies.

not able to eat, the pregnant woman can develop signs of starvation

multiple pregnancies
trophoblastic disease
hyperthyroidism
nulliparity
obesity
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9
Q

signs of hyperemesis gravidarum

A

ketones in urine
tachycardia
hypotension

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10
Q

RFs that make you more likely to experience N/V

A

If you are having a female baby.
If this is your first pregnancy.
If you have had - or your mother or sister has had - nausea and vomiting in previous pregnancies.
If you are having twins or another multiple pregnancy.
If you have a history of motion sickness.
If you have a history of migraines.
If you have experienced nausea when taking the combined oral contraceptive pill.
If you are stressed or anxious about something.
If you are obese.
If you are a younger woman

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11
Q

why does reflux occur in pregnant women

A

The increased level of certain hormones that occurs has a relaxing effect on the sphincter muscle. That is, the tightness (tone) of the sphincter is reduced during pregnancy.

The size of the baby in the tummy (abdomen) causes an increased pressure on the stomach.

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12
Q

Sx of reflux in pregnant women

A

Heartburn. This is a burning feeling which rises from the upper tummy (abdomen) or lower chest up towards the neck.

Waterbrash. This is a sudden flow of sour-tasting saliva in your mouth.

Upper abdominal pain or discomfort.
Pain in the centre of the chest behind the breastbone (sternum).
Feeling sick (nausea) and being sick (vomiting).
Bloating.
Quickly feeling ‘full’ after eating.

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13
Q

lifestyle modification advise for reflux in pregnant women

A

avoid triggers

good posture

bedtime

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14
Q

what foods to avoid that may prompt pregnancy

A
Peppermint.
Tomatoes.
Chocolate.
Fatty and spicy foods.
Fruit juices.
Hot drinks.
Coffee.
Alcoholic drinks. (Current advice is t
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15
Q

medication for reflux to give pregnant women

A

antacids - contain Mg or Al ‘as required basis’

contain SODIUM CARBONATE OR MAGNESIUM TRISILLICATE SHOULD BE AVOIDED AS THEY CAN HARM BABY

take it 2 hours before or after iron supplements

alginates

omeprazole

ranitidine

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16
Q

Sx of constipation in pregnancy

A

Opening the bowels less than usual.

Passing hard, pellet-like stools.

Tummy cramps.

Wind.

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17
Q

if lifestyle modification for contsipation fails what meds can be given

A

‘Softening’ laxatives
These simply soften the stools. They tend to cause more wind and are not always helpful in pregnancy. This is because they don’t tend to speed the passage of the stool very well through the bowel.

‘Stimulant’ laxatives
These tend to make the bowel work faster. They are more effective than softening laxatives in pregnancy. However, they can cause cramping pains and wind as they start to work.

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18
Q

why can pregnant women feel breathless

A

diaphragm gets squashed by baby so less space for it to expand

lead to hyperventilation
- panicky, tingly, dizzy and faint.

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19
Q

other causes of breathlessness in pregnancy

A

asthma

anaemia

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20
Q

Sx of piles

A

swollen veins around the back passage
itchy, ache, throb
bleeding

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21
Q

what are the Sx of varicose veins in pregnancy

A

Aching and pain in the legs.

Swelling of the feet and ankles.

Vulval varicose veins, which cause aching and throbbing in the vulval area. This is worse on standing.

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22
Q

what is pelvic girdle pain

A

symphysis pubis is the joint between the two halves of the pelvis at the front - down low, over the front of your bladder. It can become very painful in pregnancy

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23
Q

why does pelvic girdle pain occur in pregnant women

A

joint in the bone can become loosened and the bones separate a little and then rub against one another.

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24
Q

Mx pelvic girdle pain

A

pillow between the knees

exercise
phsiotherapy

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25
Q

when should screening for anaemia should take place

A

booking

28 weeks of gestation

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26
Q

level of Hb to diagnsoe anaemia at booking and at 2/3rd tirmester

A

less than 110

less that 150

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27
Q

most common symptoms of anaemia in pregnant women

A

Fatigue
Dyspnoea
Dizziness

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28
Q

Ix for anaemia in pregnant women

A

Hb

MCV less than 76

normal MCV - (76-96)

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29
Q

Mx of anaemia in pregnant women

A

established iron deficiency anaemia
100-200mg of iron daily
should continue for at least three months and at least six weeks postpartum

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30
Q

Ix for thalasseamias

A

MCV ≤80 fl requires investigation, with an HbA2 ≥3.5% being positive for B2-thalassaemia.

Chorionic villus sampling in the first quarter of pregnancy and fetal cord blood sampling under ultrasound guidance in the second quarter can be used to detect B2-thalassaemia major, and termination of pregnancy offered.

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31
Q

If sickle cell anaemia is suspected what do u do

A

Where suspected, women should receive folate supplementation of 5 mg per day. FBC should be routinely checked at 20, 28 and 32 weeks.

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32
Q

complications of anaemia

A
Maternal death.
Fetal death.
Premature delivery.
Low birth-weight babies.
Cardiac failure.
Their babies having subsequent developmental problems.
Poor work capacity/performance.
Susceptibility to infection.
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33
Q

when can u say a preg woman has had significant exposure to VZV

A

Significant exposure to chickenpox includes having face-to-face contact, being in the same room for 15 minutes of more, or in a large open ward. It is also important to enquire about contact before the chickenpox rash develops (as infectivity begins 2 days before the onset of the rash until lesions crust).

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34
Q

how do you check if women is immune to VZV or not

A

blood test to VZV

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35
Q

If exposure is deemed to be significant and the pregnant woman is non-immune AND <20 WEEKS what do u fo

A

give VZIG within 10 days of the exposure as it help prevent or attenuate chickenpox IF GESTATION <20 WEEKS

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36
Q

If exposure is deemed to be significant and the pregnant woman is non-immune AND >20 WEEKS what do u fo

A

VZIG or aciclovir within days 7 to 14 after exposure

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37
Q

VZV risk to mother

A

varicella pneumonitis, hepatitis or encephalitis

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38
Q

features of fetal varicella syndrome

A
  • Fetal growth restriction
  • Microcephaly, hydrocephalus and learning disability
  • Scars and significant skin changes located in specific dermatomes
  • Limb hypoplasia (underdeveloped limbs)
  • Cataracts and inflammation in the eye (chorioretinitis)

skin scarring

eye defects (microphthalmia)

limb hypoplasia

microcephaly

learning disabilities

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39
Q

if women gets chickenpox while pregnant

A

> 20 weeks guve aciclovir within 24 hours of onset of the rash

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40
Q

RFs of HELLP syndrome

A
Age >35.
Nulliparity.
Previous gestational hypertension.
Multiple pregnancy.
Previous HELLP syndrome.
Caucasian racial origin.
Antiphospholipid syndrome (APS) - 10.5% of patients with HELLP syndrome have APS
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41
Q

presentation of HELLP syndrome

A

onspecific symptoms including malaise, fatigue, right upper quadrant or epigastric pain, nausea, vomiting, or flu-like symptoms.

worst at night but gets better during the day

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42
Q

OE of HELLP

A

oedema
HTN
proteinuria

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43
Q

Ix of HELLP

A

Haemolysis with fragmented red cells on the blood film, due to microangiopathic haemolytic anaemia.

raised LDH and bilirubin due to destruction of RBCs

AST/ALT is also elevated

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44
Q

Mx of HELLP

A

delivery of fetus

45
Q

maternal and fetal complications of HELLP

A

eclampsia

placental abruption

DIC

AKI

fetal
perinatal death
intrauterine growth restriction

46
Q

causes of jaundice in pregnancy

A

intrahepatic cholestasis of pregnancy

acute fatty liver of pregnancy

47
Q

what is intrahepatic cholestasis of pregnancy

A

seen in third trimester

48
Q

features of intrahepatic cholestasis of pregnancy

A
  • pruritus, often in the palms and soles - can be skin trauma from intense scratching
  • no rash (although skin changes may be seen due to scratching)
  • intense in night
  • insomnia and malaise
  • raised bilirubin
49
Q

Mx of intrahepatic cholestasis of pregnancy

A

maternal Vit K
neonatal Vit K

Drug treatment to reduce pruritus
--- Ursodeoxycholic acid
--- Antihistamine
--- Calamine 
- Delivery at fetal maturity
LFTS measured weekly until they go into labour 
- PN f up LFT 10days PN
  • risk reduced by IOL after 37 weeks

if PTT prolonged

  • Maternal Vitamin K
  • Neonatal Vitamin K as soon as they born
  • Fetal surveillance
50
Q

when does acute fatty liver of pregnancy occur

A

rare complication which may occur in the third trimester or the period immediately following delivery.

51
Q

Features of acute fatty liver of pregnancy

A
abdominal pain
nausea & vomiting
headache
jaundice
hypoglycaemia
severe disease may result in pre-eclampsia
52
Q

Ix of acute fatty liver of pregnancy

A

ALT above 500u/l

53
Q

Mx of acute fatty liver or pregnancy

A

support care

once stabilised delivery is the definitive management

54
Q

what is eclampsia

A

is a serious complication of pre-eclampsia

where the high BP causes seizures

55
Q

Mx to prevent exclampsia or treat it

A

magnesium sulphate
in eclampsia an IV bolus of 4g over 5-10 minutes should be given followed by an infusion of 1g / hour
urine output, reflexes, respiratory rate and oxygen saturations should be monitored during treatment
respiratory depression can occur: calcium gluconate is the first-line treatment for magnesium sulphate induced respiratory depression
treatment should continue for 24 hours after last seizure or delivery (around 40% of seizures occur post-partum)

  • a woman at moderate or high risk of pre-eclampsia should take aspirin 75mg daily from 12 weeks gestation until the birth
  • consensus guidelines recommend treating blood pressure > 160/110 mmHg although many clinicians have a lower threshold
  • oral labetalol is now first-line following the 2010 NICE guidelines. Nifedipine (e.g. if asthmatic) and hydralazine may also be used

delivery of the baby is the most important and definitive management step. The timing depends on the individual clinical scenario (AFTER 34 WEEKS SSAME DAY DELIVERY IS AN OPTION)

Epidural reduces BP

56
Q

risks of smoking to the baby

A
  • increased risk of miscarriage (increased risk of around 47%)
  • Increased risk of pre-term labour
  • Increased risk of stillbirth
  • IUGR
  • Increased risk of - sudden unexpected death in infancy
57
Q

risks of alcohol to the baby

A

Fetal alcohol syndrome (FAS)

  • learning difficulties
  • characteristic facies: smooth philtrum, thin vermilion, small palpebral fissures, epicanthic folds, microcephaly
  • IUGR & postnatal restricted growth

Binge drinking is a major risk factor for FAS

58
Q

cocaine risks to the baby

A

Maternal risks
hypertension in pregnancy including pre-eclampsia
placental abruption

Fetal risk
prematurity
neonatal abstinence syndrome

59
Q

heroin risk to the baby

A

Risk of neonatal abstinence syndrome

60
Q

what is placental abrutpion

A

premature separation of a normally placed placenta before delivery of fetus

blood starts collecting between the placenta and the uterus

61
Q

presentation of placental abruption

A

May present with vaginal bleeding, abdominal pain (usually continuous), uterine contractions, shock or fetal distress

shock out of keeping with visible loss
pain constant
tender, tense uterus
normal lie and presentation
fetal heart: absent/distressed
coagulation problems
beware pre-eclampsia, DIC, anuria
62
Q

intrahepatic cholestasis increases risks of what

A

foetal distress
intrauterine death
maternal morbidity

63
Q

if u see rash in pregnancy what should u rule out

A

Polumorphic Eruption Pregnancy

pemphigoid gestations

64
Q

Ix for obstetric cholestasis

A
  • LFT and Bile acid
  • Viral screen
    Hepatitis A, B, and C, Epstein Barr and cytomegalovirus,
  • Liver autoimmune screen
    chronic active hepatitis and primary biliary cirrhosis
    anti-smooth muscle and antimitochondrial antibodies

USS abdomen –Liver and Gall stones

65
Q

what will be seen in OC Ix

A
  • Elevated transaminases
  • Alkaline phosphatase
  • Raised gamma-glutamyl transferases
  • Mild elevation in bilirubin
  • Primary bile acids increased up to 100 fold
66
Q

maternal risks of O Cholestasis

A

Vit K deficiency - disturbs coagulation pathway

increased risk of PPH

67
Q

fetal risks of OC

A
  • Perinatal mortality is increased to up to 11%
  • Fetal distress
  • Meconium
  • Preterm labour
  • Intracranial haemorrhage
  • Stillbirth

No effective fetal monitoring available!!

68
Q

what are the procoagulant pathophysiological changes in pregnancy

A
  • Hypercoagulable state
  • Increase in fibrinogen and factors VIII, IX and X
  • Concentration of endogenous anticoagulants decreases
  • Additional risk is present for at least 6 weeks postpartum
  • Venous stasis in lower limbs
  • Trauma of pelvic veins at the time of delivery
69
Q

pre-existing risk factors of thromboembolism

A
  • Obesity BMI>30
  • Age>35
  • Parity>3
  • Smoking
  • Gross varicose veins
  • Paraplegia
  • Medical comorbidities
  • Thrombophilia
  • Previous VTE
70
Q

obstetric RFs of thromboembolism

A
Multiple pregnancy
PET
CS
Prolonged labour >24 hrs
Mid-cavity or rotational operative delivery
Still birth
Preterm birth
PPH>1L
71
Q

new onset reversible factors of thromboembolism

A
Bone fracture
Surgical procedure in pregnancy and puerperium
Hyperemesis, dehydration
OHSS/ART
Immobility >3 days
Long Haul travel >4 hours
Current systemic infection
72
Q

gold standard Ix of DVT

A

venography with fetal shield

73
Q

Ix for PE

A

Chest X-ray
often -normal but excludes other causes of breathlessness
may - atelectasis, wedge shaped infarction, pleural effusion

ECG may only show sinus tachycardia, the classical S1Q3 T3 is rare

There may be Leukocytosis

Arterial blood gases may show hypocapnia +/- hypoxaemia

Oxygen saturation may fall 3-4% after exercise

74
Q

diagnosis can be made w which Ix

A

lung scan

75
Q

first line Ix for DVTq

A

doppler

76
Q

suspect PE what do u do

A

– clinical assessment
– perform CXR and ECG
– test FBC, U&E, LFTs
– commence LMWH

(unless treatment is contraindicated)

  • Duplex USS for S/S of DVT
  • VQ scan if chest x-ray normal
  • CTPA if chest x-ray abnormal
77
Q

Mx of PE

A
  • Full anticoagulation with low molecular weight Heparin, e.g. Dalteparin, /Enoxaparin
  • TEDS
  • Leg care advice
  • Advice re need for future prophylaxis for
    pregnancy, surgery, flying etc.
  • In high risk cases consider vena cava filters
78
Q

what is given to women who have epilepsy and want to get pregnant

A

Epilepsy + pregnancy = 5mg folic acid before conception to reduce neural tube defects

79
Q
what is 
sodium valporate
carbamazepine
phenytoin
lamotrigine
ass w
A

sodium valproate: associated with neural tube defects

carbamazepine: often considered the least teratogenic of the older antiepileptics
phenytoin: associated with cleft palate
lamotrigine: studies to date suggest the rate of congenital malformations may be low. The dose of lamotrigine may need to be increased in pregnancy

80
Q

what is given to pregnant women taking phenytoin

A

Vitamin K

prevent clotting disorders in the newborn

81
Q

associated factors of placental abruption

A
proteinuric hypertension
cocaine use
multiparity
maternal trauma
increasing maternal age
82
Q

what is the hyperemesis gravidarum triad and this is the diagnosis

A

5% pre-pregnancy weight loss

dehydration

electrolyte imbalance

83
Q

when is hyperemesis gravidarum common

A

between 8-12 weeks may persist upto 20 weeks

84
Q

hyperemesis gravidarum ass

A
  • multiple pregnancies
  • trophoblastic disease
  • hyperthyroidism
  • nulliparity
  • obesity
85
Q

what is the referral criteria for N&V in pregnancy

A
  • Continued nausea and vomiting and is unable to keep down liquids or oral antiemetics
  • Continued nausea and vomiting with ketonuria and/or weight loss (greater than 5% of body weight), despite treatment with oral antiemetics
  • A confirmed or suspected comorbidity (for example she is unable to tolerate oral antibiotics for a urinary tract infection)
86
Q

what is used to classify the severity of nausea and vomitng of pregnancy

A

Pregnancy-Unique Quantification of Emesis (PUQE)

87
Q

Mx for hyperemesis gravidarum

A

1) antihistamines - promethazine
cyclizine

2) ondansetron and metoclopramide
- extrapyramidal side effects

88
Q

complications of hyperemesis gravidarum

A
Wernicke's encephalopathy
Mallory-Weiss tear
central pontine myelinolysis
acute tubular necrosis
fetal: small for gestational age, pre-term birth
89
Q

in first week of life if breastfeeding baby loses more than 10% of weight what do u do

A

breastfeeding clinic

90
Q

common breastfeeding problems and their Mx

A

mastitis
mx - flucoxacillin for 10-14 days

engorgement
mx - just give milk

raynauds
- no caffein no smoking
heat packs

91
Q

what is extrapyramidal side effects

A

drug-induced movement disorders

92
Q

Ix for hyperemesis gravidarum

A
  • urine dipstick -> ketonuria
  • MSU
  • U&Es - hypokalaemia, hyponatraemia, dehydration, renal disease
    FBC - infection, anaemia, haematocrit
    Glucose - DKA
    US scan - confirm viable intrauterine pregnancy
  • exclude multiple pregnancy and trophoblastic disease
    TFTS, LFTs, calcium and phosphate, amylase: exclude pancreatitis
    ABG
93
Q

what is oligohydraminos

A

reduced amniotic fluid

<500 ml at 32-36 weeks

AFI <5TH PERCENTILE

94
Q

Causes of oligohydraminos

A
fetal
Chromosomal factors.
Congenital factors.
Intrauterine growth restriction.
Post-term pregnancy.
Premature ROM (PROM).
Fetal demise.

placental
abruption
twin-to-twin transfusion syndrome

maternal
Maternal dehydration.
Uteroplacental insufficiency.
Hypertension.
Pre-eclampsia.
Diabetes (either pre-existing or gestational diabetes).
Chronic hypoxia.

indometacin adn ACE inhibitors
idiopathic

95
Q

Mx of VTE

A
  • Four or more risk factors warrants immediate treatment with low molecular weight heparin continued until six weeks postnatal.

If a woman has three risk factors low molecular weight heparin should be initiated from 28 weeks and continued until six weeks postnatal.

If diagnosis of DVT is made shortly before delivery, continue anticoagulation treatment for at least 3 month, as in other patients with provoked DVTs.

96
Q

what Mx should be avoided in pregnancy

A

DOAC

warfarin

97
Q

which antiepileptic safe in pregnancy and is not

A

Levetiracetam, lamotrigine and carbamazepine

NOT
sodium valporate
phenytoin

98
Q

pre-eclampsia predisposes u to

A

fetal: prematurity, intrauterine growth retardation
eclampsia
haemorrhage: placental abruption, intra-abdominal, intra-cerebral
cardiac failure
multi-organ failure

99
Q

what is rubella

A

German measles. Congenital rubella syndrome is caused by maternal infection with the rubella virus during the first 20 weeks of pregnancy. The risk is highest before ten weeks gestation.

MMR vaccine if in doubt test for rubella immunity

can be vaccinated with two doses of the MMR three months apart before conception NOT PREGNANT

100
Q

features of congential rubella syndrome

A

Congenital deafness
Congenital cataracts
Congenital heart disease (PDA and pulmonary stenosis)
Learning disability

101
Q

what is listeria

A

infectious gram-positive bacteria that causes listeriosis.

high rate of miscarriage or fetal death. It can also cause severe neonatal infection.

transmitted by unpasteurised dairy products, processed meats and contaminated foods. Pregnant women are advised to avoid high-risk foods (e.g. blue cheese) and practice good food hygiene.

102
Q

features of CMV

A
Fetal growth restriction
Microcephaly
Hearing loss
Vision loss
Learning disability
Seizures

virus is mostly spread via the infected saliva or urine of asymptomatic children

103
Q

features of toxoplasmosis

A

Intracranial calcification
Hydrocephalus
Chorioretinitis (inflammation of the choroid and retina in the eye)

faeces from a cat that is a host of the parasite

104
Q

what is parvovirus B19

features

A

ifth disease, slapped cheek syndrome and erythema infectiosum

self limiting -> rash and symptoms usually fade over 1 – 2 weeks.

on-specific viral symptoms. After 2 – 5 days, the rash appears quite rapidly as a diffuse bright red rash on both cheeks, as though they have “slapped cheeks”. A few days later a reticular mildly erythematous rash affecting the trunk and limbs appears, which can be raised and itchy. Reticular means net-like.

105
Q

complications of parvovirus B19

A

Miscarriage or fetal death

Severe fetal anaemia - infects the erythroid progenitor cells in the fetal bone marrow and liver

Hydrops fetalis (fetal heart failure)

Maternal pre-eclampsia-like syndrome -> hydrops fetalis, placental oedema and oedema in the mother. It also features hypertension and proteinuria.

106
Q

Ix for parvovirus B19

A

IgM to parvovirus, which tests for acute infection within the past four weeks

IgG to parvovirus, which tests for long term immunity to the virus after a previous infection

Rubella antibodies (as a differential diagnosis)

107
Q

Zika virus

A

Aedes mosquitos

spread by sex with someone infected with the virus.

Microcephaly
Fetal growth restriction
Other intracranial abnormalities, such as ventriculomegaly and cerebellar atrophy

Mx
viral PCR and ABs to the zika virus

108
Q

how should OC be monitored

A

Once obstetric cholestasis is diagnosed, it is reasonable to measure LFTs weekly until
delivery.

Postnatally, LFTs should be deferred for at least 10 days