Medical Problems in Pregnancy Flashcards

1
Q

List common medical problems in pregnancy

A
VTE
Diabetes
Hypertension
Cardiac disease
Asthma
CTD (antiphospholipid syndrome)
Epilepsy
Obesity
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2
Q

What are the significant cardiovascular changes that occur in pregnancy?

A

Increased CO

Increased HR

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3
Q

List common cardiac conditions that require management in pregnancy

A
Pulmonary hypertension
Congenital or acquired heart disease
Cardiomyopathy
Artificial heart valves
Ischaemic heart disease
Arrhythmia
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4
Q

Which emergency condition is a patient with Marfan’s syndrome at risk of during pregnancy?

A

Aortic dissection

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5
Q

Arrhythmia during pregnancy are typically benign. True/ False?

A

True

Palpitations, extrasystoles and systolic murmurs.

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6
Q

When do physiological arrhythmias typically occur?

A

At rest or lying down

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7
Q

State the name for the common arrhythmia described as a ‘thumping’ and is relieved by exercise . How is it diagnosed?

A

Ectopic beats

ECG

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8
Q

Which type of arrhythmia is a part of normal pregnancy?

A

Sinus tachycardia

Exclude other pathology (ECG, FBC, TFT, echo)

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9
Q

What type of arryhtmia is typically detected at pregnancy, but is found to predate pregnancy?

A

Supraventricular tachycardia

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10
Q

O2 consumption and tidal volume increase during pregnancy. What is the anatomical explanation for this change in lung function?

A

Increased level of diaphragm

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11
Q

When is breathlessness in pregnancy most common?

A

3rd trimester

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12
Q

State the most common chronic medical disorder to complicate pregnancy

A

Asthma

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13
Q

Asthma always gets worse during pregnancy. True/ False?

A

False

May improve, deteriorate or remain unchanged

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14
Q

Outline the stepwise management of asthma during pregnancy

A
  1. SABA
    • inhaled steroid
    • LABA
      - If good response, continue
      - If poor response, stop
      - If inadequate response, increase dose of steroid
  2. Trial of increased dose of steroid
    Consider adding 4th drug (LTRA, theophylline)
  3. Oral steroid and continuation of inhaled steroid
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15
Q

When is risk of VTE highest for a pregnant women?

A

Post-partum

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16
Q

What is the most common site of DVT in pregnancy?

A

Left leg

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17
Q

Popliteal DVT is the most common type of DVT in pregnancy? True/ False?

A

False

Ileo-femoral, unlike DVT in non-pregnnacy

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18
Q

What is the leading cause of maternal death in pregnancy?

A

Venous thromboembolism

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19
Q

Outline the pathogenesis of VTE

A

Virchows triad
- Hypercoagulability
Venous stasis
Vascular damage

20
Q

List risk factors for VTE during pregnancy

A
Previous VTE (not related to surgery)
Thrombophilia
Co-morbidity (cancer, HF, SLE, IBD, DM, nephrotic syndrome, preclampsia)
IVDU, smoker, obesity
Any surgery
Age > 35 or partity > 3
Family history
21
Q

List clinical signs of DVT, which can also be present during normal pregnancy

A
Swelling
Oedema
Leg pain or discomfort
Tenderness
Increased leg temperature
Lower abdominal pain
Increased WCC
22
Q

List investigations used to diagnose DVT in pregnancy

A

Compression Duplex US

Repeat in 1w if normal to exclude calf vein thrombosis

23
Q

If iliac vein thrombosis suspected after compression duplex US, which investigation should be requested?

A

MRI venography

24
Q

List clinical signs of PE during pregnancy

A
Dyspnoea
Chest pain
Faintness/ collapse
Haemoptysis
Raised JVP
Focal signs in chest
Signs assoc. DVT
25
A D-dimer test should be carried out in pregnancy to investigate PE. True/False?
False | Never do D-dimer in pregnancy, do a CTPA or VQ scan instead
26
What drug is used to combat PE in pregnancy?
Heparin
27
List some side effects of heparin
Haemorrhage Hypersensitivity Thrombocytopenia Osteopenia
28
Warfarin can be used to manage PE in pregnancy. True/ False?
False | Warfarin crosses placenta and is teratogenic, convert to LMWH by 6 weeks
29
Warfarin is suitable for use while breastfeeding. True/ False?
True | It is not contraindicated - commence warfarin on 5th post-natal day
30
Which medications used in the treatment of CTD are safe for use in pregnancy?
``` Steroids Azathioprine Sulfazaline Hydroxychloroquine Aspirin ```
31
What is anti-phospholipid syndrome and how does it present?
Acquired thrombophilia which presents with: Arterial/ venous thrombosis Recurrent early pregnancy loss (>2 in <10w) Late pregnancy loss (preceded by FGR) at >10w Placental abruption PET (>1 preterm birth)
32
Outline the pathogenesis behind APS
AP autoantibodies react with phospholipid component of CM
33
How is APS diagnosed in the lab?
IgM/ IgG aCL (medium/ high titre) LA On 2 occassions more than 6 weeks apart
34
How is APS managed?
Previous thrombosis: LDA + treatment dose of LMWH | Fetal loss/ severe PET/ FGR: LDA + prophylactic LMWH
35
In a person with epilepsy, during which trimester are they at increased risk of seizures?
1st trimester due to hyperemesis and haemodilution
36
What are the risks of seizures during pregnancy?
``` Spontaneous miscarriage PPH Hypertension/ PET Preterm birth Fetal growth restriction Congenital malformation Childhood epilepsy ```
37
Which epileptic drug is especially associated with neural tube defects?
Sodium valproate
38
Outline management options for epilepsy during pregnancy
Use lowest effective dose of AED Detailed 20w US for fetal anomaly Folic acid 5mg/day to reduce congenital malformations Baby safety
39
Outline management optons for epilepsy during labour
``` Aim for vaginal birth, may need C section Continuous fetal monitoring IV lorazepam/ diazepam IV phenytoin PR diazepam/ buccal midazolam ```
40
If no history of epilepsy, how are seizures managed during labour?
Magnesium sulphate
41
What are the maternal risks of obesity during pregnancy?
``` Miscarriage GDM Hypertension/ PET VTE PPH ```
42
What are the fetal risks of obesity during pregnancy?
``` Congenital anomalies Macrosomia Shoulder dystocia Still birth Neonatal death ```
43
Outline management options for obesity during pregnancy
``` Maternal BMI at booking PET prophylaxis (Aspirin) Thromboprophylaxis Detailed US OGTT Anaesthetic review ```
44
List pregnancy-related MSK problems
Back pain Pelvic girdle pain Diastasis of rectus abdominus muscle (DRAM) Carpal tunnel syndrome
45
What is diastasis recti?
Seperation of the two sides of the rectus abdominus muscle due to stretching of the linea alba