Med Review Benzos and antiemetics Flashcards
The primary effects from benzodiazepine administration include what?
- sedation
- amnesia
- anxiolysis
- hypnotic
- anticonvulsant
- spinal cord-mediated sk-m relaxation
Which is the most potent out of the benzodiazepines? which is the least potent?
lorazepam > Midazolam > diazepam
lorazepam 5x more potent than midazolam
midazolam 5x more potent than diazepam
What cardiovascular effects may occur with benzo administration?
- minimal CV effects with sedative dose
- may get small drop in BP
What respiratory effects may occur with benzo administration?
- dose dependent respiratory depression
- depression of airway reflexes (at higher doses)
- hypoxic drive to breath is depressed
When would hypoxic drive depression be a major issue?
Significant respiratory depression in patients using oxygen/hypoxia to trigger breathing (COPD, Sleep apnea, morbid obesity)
True or false: benzodiazepines blunt the SNS response to laryngoscopy
false: BZD do not blunt SNS response to laryngoscopy
What drug is typically used to reverse benzodiazepines?
Flumazenil (romazicon)
What major consideration should be made with zofran administration?
watch from QT prolongation
What considerations should be made with droperidol administration?
- Watch QT
- can cause sedation/confusion
What negative effects are associated with administration of reglan?
- can cause anxiety
- Extrapyramidal side effects
What H2blocker is FDA approved for treatment of morning sickness?
Famotidine (pepcid)
What considerations should be made with administration of phenergan?
- sedation qualities
- extravasation risk
What is a new drug for high risk N/V patients that acts as a substance P/NK-1 antagonist?
Aprepitant (emend)
