Dosages NMBs, LAs, Pressors Flashcards
What is the dose of Succinylcholine?
Onset:
Duration:
Metabolism:
Succinylcholine (Anectine)
Dose: 1 mg/kg IV
Onset: 30-60 seconds
Duration: 3-5 minutes
Metabolism: pseudocholinesterase
Dantrolene
Dose:
Metabolism:
Dantrolene (Ryanodex)
Dose: 2mg/kg IV
Repeat doses until symptoms subside or 10mg/kg IV
Metabolism: Hepatic
What is the dose of SCh for MG patients?
1.5-2.0 mg/kg
(increased d/t resistance)
For a patient with burns needing intubation, how can we offset the resistance to non-depolarizing blockers the burn causes?
1.2 mg/kg dose of Rocuronium
Pancuronium
Dose:
Onset:
Duration:
Metabolism:
Pancuronium (Pavulon)
- Dose: 0.1mg/kg;
- Onset: 3-5 minutes;
- Duration: 60-90 minutes
Metabolism: Hepatic
Excretion: 80% unchanged in Urine
Vecuronium
Dose:
Onset:
Duration:
Metabolism:
Vecuronium (Norcuron)
- Intubating Dose: 0.1 mg/kg
- Onset: 3-5 minutes
- Duration: 20-35 minutes
Metabolism: 70% Hepatic
Excretion: 30% unchanged in Urine
Rocuronium
Normal Dose:
Onset:
Duration:
Metabolism:
Excretion:
Rocuronium (Zemuron)
* Dose: 0.6 mg/kg
* Onset: 3-5 minutes
* Duration: 20-35 minutes
Metabolism: Hepatic
Excretion: Bile, 10-30% Renal
Rocuronium
RSI Dose:
Onset:
Duration:
Metabolism:
Excretion:
Rocuronium (Zemuron)
- Dose: 1.2 mg/kg
- Onset: 1-2 minutes
- Duration: 60-90 minutes
Metabolism: Hepatic
Excretion: Bile, 10-30% Renal
Cisatracurium
Dose:
Onset:
Duration:
Metabolism:
Cisatracurium (Nimbex)
* Intubating Dose: 0.1 mg/kg;
* Onset: 3-5 minutes;
* Duration of action: 20-35 minutes
Metabolism: Hoffman elim & plasma cholinesterase
Mivacurium
Dose:
Onset:
Duration:
Metabolism:
Mivacurium (Mivacron)
* Intubating Dose: 0.15 mg/kg;
* Onset: 2-3 minutes (Conditions less desirable);
* Duration: 12-20 minutes
Metabolism: plasma cholinesterase
Neostigmine
Dose:
Max:
Onset:
Duration:
Neostigmine (prostigmine)
Dose: 40 - 70 mcg/kg
Max: 5mg
Onset: 5-10 min
Duration: 60 min
Edrophonium
Dose:
Onset:
Duration:
Edrophonium (Tensilon)
Dose: 0.5 - 1 mg/kg
Onset: 1-2 min
Duration: 5-15min
What is the dose of Atropine?
7 - 10 mcg/kg
What is the Sugammadex dose for a moderate block?
Onset:
Duration:
Elimination:
Sugammadex (Bridion)
2 mg/kg
Onset: 1-4 min
Duration: 1.5 - 3 hours
Elimination: Urine
What is the Sugammadex dose for a deep block?
4 mg/kg
What is the sugammadex dose for an extreme block?
8 - 16 mg/kg
What drug and dose would be a good choice for a recurarizing patient in the PACU?
Why might this be a good choice?
- Neostigmine 0.05 mg/kg IV (40-70mcg/kg)
- Longer duration of action (60min)
What is the dose and max for glycopyrrolate?
7 - 15 mcg/kg
1mg maximum
MAGA: What is the intra-op infusion dose of lidocaine?
1 mg/kg over an hour
What is the IV dose of Lidocaine? (bolus and drip)
- 1 to 2 mg/kg IV (initial bolus) over 2 - 4 min.
- 1 to 2 mg/kg/hour (drip)
What is Lidocaine’s max infiltration dose? (with and without Epi)
- 300 mg plain
- 500 mg with Epi