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.Drug Doses/Info > Dosages Induction Meds > Flashcards

Dosages Induction Meds Flashcards

1
Q

What is the dose for Thiopental?

A
  • 4mg/kg IV
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2
Q

What is the IV methohexital dose?
What if it needs to be given rectally?

A
  • 1.5 mg/kg IV
  • 20 - 30 mg/kg PR
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3
Q

For Propofol, what are the doses for:
1. Induction
2. Maintenance
3. Conscious sedation

A
  1. Induction = 1.5 - 2.5 mg/kg IV
  2. Maintenance = 100 - 300 μg/kg/min
  3. Conscious sedation = 25 - 100 μg/kg/min
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4
Q

What is the induction dose of propofol in adults?
Metabolism:
Excretion:
E1/2:

A

Diprivan/Propofol
Adults: 1.5-2.5 mg/kg IV
Metabolism: CYP
Excretion: Renal
E1/2: 0.5-1.5 hours

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5
Q

What is the conscious sedation dose of propofol?

A
  • 25 - 100 μg/kg/min
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6
Q

What is the sub-hypnotic dosing for propofol?

A
  • 10 - 15 mg IV, followed by 10 mcg/kg/min
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7
Q

What is the anti-pruritic dosing of propofol?

A
  • 10 mg IV
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8
Q

What is the anti-convulsant dosing of propofol?

A

1mg/kg IV

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9
Q

What is the induction dose for etomidate?
Onset:
Metabolism:
Excretion:
E1/2:

A

Etomidate/Amidate
Dose: 0.3 mg/kg IV
Onset: 1 min
Metabolism: CYP, plasma esterase
Excretion: 85% urine, 13% bile
E1/2: 2-5 hours

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10
Q

What can be administered with etomidate to prevent involuntary myoclonic movements?

A

Fentanyl 1-2 μg/kg IV

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11
Q

What is the induction dose of ketamine IV?
Onset:
Duration:
Metabolism:
Excretion:
E1/2:

A

Ketamine/Ketalar
Dose: 0.5 - 1.5 mg/kg IV
Onset: 1 min
Duration: 10-20 min
Metabolism: CYP
Excretion: Renal
E1/2: 2-3 hours

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12
Q

What is the IM dose of ketamine?

A

4 - 8 mg/kg IM

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13
Q

What is the maintenance and subanesthetic/analgesic dose of ketamine?

A
  • 0.2 - 0.5 mg/kg IV
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14
Q

What is the post-operative sedation and analgesia dosing for ketamine in pediatric cardiac surgery cases?

A

1-2 mg/kg/hour

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15
Q

What is the neuraxial epidural analgesia dosing of ketamine?
What about intrathecal route?

A
  • 30mg epidural
  • 5 - 50 mg via intrathecal/spinal/subarachnoid
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16
Q

What drug and dosing should be used to treat excessive salivary secretions from ketamine administration?

A

Glycopyrrolate: 0.2mg

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17
Q

At what dosing will the ICP increasing effects of ketamine plateau?

A
  • 2mg/kg IV
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18
Q

What is the dosage of morphine?
Onset:
Peak:
Duration:
Metabolism:
E1/2:

A
  • 1 - 10 mg IV
    Onset: 10-20 min
    Peak: 15 - 30 minutes
    Duration: 4-5 hours
    Metabolism: glucuronic conjugation
    E1/2: 1.5-3.5 hours
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19
Q

What is the primary indication for meperidine?
What dose is used?

A
  • Post-operative shivering
  • 12.5mg IV
20
Q

What is the analgesia dosage of fentanyl?
Induction dose?
Onset:
Duration:
Metabolism:
Clearance:

A
  • Analgesia: 1 - 2 μg/kg IV
  • Induction: 1.5 - 3 μg/kg IV
    Onset: 30-60 seconds
    Duration: 1-1.5 hours
    Metabolism: CYP
    Clearance: kidneys
21
Q

What is the intrathecal dosage of fentanyl?

A

25 mcg

22
Q

What is the adult oral dose of fentanyl?
Pediatric?

A
  • Adult: 5 - 20 mcg/kg
  • Peds: 15 - 20 mcg/kg
23
Q

What is the transdermal dose of fentanyl?

A
  • 75 - 100 μg (18 hours steady delivery)
24
Q

What is the analgesia dose of sufentanil?

A
  • Analgesia: 0.1 - 0.4 μg/kg IV
25
Q

What is the induction dose of sufentanil?

A

18.9 mcg/kg IV

26
Q

What is the alfentanil induction dose?
What about laryngoscopy dose?
What about maintenance?

A
  • Induction: 150 - 300 μg/kg IV
  • Laryngoscopy: 15 - 30 μg/kg IV
  • Maintenance: 25 - 150 μg/kg/hr IV with inhaled anesthetics
27
Q

What is the induction dose of remifentanil?
Onset:
Duration:
Metabolism:

A
  • 0.5 - 1 μg/kg IV over 1 min
    Onset: 30-60 seconds
    Duration: 6-8 min
    Metabolism: tissue and plasma esterase
28
Q

What is the maintenance dosing of remifentanil?

A
  • 0.005 - 2 μg/kg/min IV
29
Q

Hydromorphone
Potency:
Dose:
Onset:
Duration:

A
  • 5x more potent than morphine
  • 0.5mg IV q4 → 1-4 mg total
    Onset: 5-15 min
    Duration: 2-4 hours
30
Q

What is the dose of codeine for cough suppression?
Analgesia?

A
  • Cough: 15mg
  • Analgesia: 60mg (= about 5mg morphine)
31
Q

What is the sufentanil intraop dose?
What is the infusion dose?

A

intraop: 0.3 - 1μg/kg IV
infusion: 0.5 - 1μg/kg/hr IV

32
Q

What is the chronic pain dose of Pentazocine?
What dose and route would be equivalent to morphine 10mg?

A
  • 10 - 30mg IV or 50 mg PO
  • 20-30mg IM = 10mg morphine
33
Q

What is the naloxone IV push dose?
Continuous infusion?
Duration:
Metabolism:
E1/2:

A

Push Dose:1-4 mcg/kg IV
Infusion: 5 mcg/kg/hr IV infusion
Duration: 30-45 min
Metabolism: Hepatic
E1/2: 60-90 min

34
Q

What dose of naloxone is use for shock?

A
  • > 1mg/kg IV
35
Q

How does nalmefene’s potency compare to naloxone?
What is it’s dose and max?

A
  • equipotent to naloxone
  • 15 - 25 mcg IV q2-5min (max of 1 mcg/kg)
36
Q

What is the dosage for Celebrex?
Peak:

A

200 to 400 mg PO QD
Peak: 3 hours

37
Q

What is the duration & dose of Ondansetron? (pediatric?)

A

Duration/plasma half life: 4 hours
Dose: Adults: 4 - 8 mg IV
Dose: Pediatrics: 0.1 mg/kg IV

38
Q

What is the dose for Dexamethasone (Decadron)?

What is the MOA of Dexamethasone (Decadron)?

A

4 - 8 mg IV

MOA: Anti-inflammatory; inhibition of phospholipase and cytokines and stabilization of cellular membrane.

39
Q

According to the TXWES medication guide, what are the doses for Acetaminophen (Ofirmev), Ketorlac (Toradol), & Ibuprofen (Caldor).

A

Slide 62

40
Q

What is the IV bolus and infusion dose of lidocaine?
When should the infusion be terminated?

A
  • 1 to 2 mg/kg IV bolus over 2-4 min.
  • 1 to 2 mg/kg/hr infusion
  • Terminated within 12-72 hours.
41
Q

What is the PO dose of preemptive Gabapentin?
When should we give it?
What is it’s MOA?

A

300-1200mg PO
1-2 hrs prior to OR
GABA analogue

42
Q

For Ofirmev, what is the Dose, Peak effect time (PO/IV), and duration?

A
43
Q

For Ketorolac, what is the:

  • MOA
  • Peak
  • Dosing
A

MOA: Inhibits PG synthesis by inhibiting COX 1 and COX 2

Peak: 45 to 60 minutes IV

Dose: 15 to 30mg q6h (1/2 dose in elderly)
Max Dose: 60-120mg QD

44
Q

What is Mg⁺⁺ dosing for the following two situations?

Preop:
Intraop:

A
  • Preop: 50 mg/kg IV
  • Intraop: 8 mg/kg/hr IV
45
Q

Ibuprofen:

  • MOA
  • Dose
  • Peak
  • Excretion
  • Contraindications
A
  • COX 1 & 2 Inhibition = ↓ PG synthesis
  • 200 - 800 mg q6h (max:3200mg QD)
  • 1-2 hours
  • Urine & Bile
    -C/I: Nephropathy, CABG, bleeding disorders, wound healing
46
Q

Using multimodal anesthesia, what 2 meds might we give in preop to better control pain later?

A

Acetaminophen 1000 mg PO, Gabapentin 300 mg PO

.Drug Doses/Info (22 decks)

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