Med ed revision session: pharmacology Flashcards
Potency
(ec 50) most potent requires least amount of drug
Efficacy
always the highest (max effect the drug can elicit)
Competitive antagonist
same shape curve displaced to right
Non comp antagonist
drug never reaches max efficacy
Therapeutic index
td50 divided by ed 50
first pass metabolism
goes through gi tract before bloodstream. this is why oral does higher than iv dose
when need to adjust dose?
if have liver failure, low meatabolism more drug in blood stream
% infusion
grams per 100 mils
g protein
g protein moves activates another protein
steroid hormones
have intracellular effect, can go straight to transcription factors
pharmokinetics
Pharmacokinetics is the study of the way in which drugs move through the body
pharmodynamics
The effect that drugs have on the body