Ischaemia/ Infarction (Friday 27th) Flashcards
Ischaemia
Organ/ tissue has lowered perfusion relative to metabolic needs.
Infarction
Need ischaemia for infarction. Localised area of tissue necrosis due to ischaemia.
Vascular Occlusion
The most important cause of ischaemia and infarction. It can be arterial, venous or capillary.
Arterial Ischaemia Causes/ Aetiology
- Atheroma and thrombrosis
- Low flow infarction: occurs in cardiovascular shock. E.G. Blood lost due to trauma. The heart does not have enough blood to pump to the tissues.
- Other - embolism, vasculitis, hypertension, spasm
Susceptibility factors in Arterial Ischaemia
- Adequacy of organ function
- Arterial supply: dual like in lung and liver may protect, single like heart is more susceptible
-Type of onset:
Slow / gradual - collaterals may develop (In anatomy, a collateral is a subordinate or accessory part. A collateral is also a side branch, as of a blood vessel or nerve. After a coronary artery occlusion, collaterals (that is, collateral vessels) often develop to shunt blood around the blockage).
Fast / sudden - more susceptible
- Tissue susceptibility: Brain most susceptible. Also heart.
Clinical Syndromes of Arterial Ischaemia
- Depends on whether vascular narrowing/ occlusion is sudden or gradual
- GRADUAL = angina but SUDDEN = myocardial infarction
- GRADUAL = hypertensive renal disease but SUDDEN = renal infarct
- GRADUAL = claudification but SUDDEN = gangrene
- GRADUAL = dementia but SUDDEN = brain infarction
- GRADUAL = ischaemic colitis but SUDDEN = gut infarct infarct
The four ways in which IHD can manifest
- Chronic Ischaemic Cardiopathy
- Cardiac Sudden Death
- Angina
- Acute Coronary Syndromes
Aspects of MI by different techniques
BIOCHEMISTRY:
- Markers of myocardial cell death recovered from blood samples
ELECTROCARDIOGRAPHY:
- Evidence of myocardial ischaemia (ST-T segment changes)
- Evidence of loss of electrically functioning cardiac tissue (Q waves)
IMAGING:
- Reduction or loss of tissue perfusion
- Cardiac wall motion abnormalities
Capillary Ischaemia Causes/ Aetiology
Blocked or damaged capillaries can lead to local ischaemia
EXAMPLES:
Frostbite
Cryoglobulinaemia
Disseminated intravascular coagulation (DIC)
Diabetic microangiopathy
Venous Ischaemia Causes/ Aetiology
Venous obstruction ultimately leads to cessation of arterial inflow, and infarction results.
The best known example of this is gut infarction in a strangulated hernia. The arrow shows a hernia in the inguinal canal.
The herniated intestines can strangulate at the OS (arrow) of the hernia, obstructing venous return, resulting in ischaemia and infarction.
ISCHAEMIC HEART DISEASE EPIDEMIOLOGY
see cvd death rates across classes
Under 40 = 10%
Under 65 = 45%
Frequency rises progressively with age and when predisposition to atheromatosis are present (hypercholesterolemia, smoking diabetes, HTS)
Women are “protected” against MI during reproductive years.
CHRONIC ISCHAEMIC CARDIOMYOPATHY
Cardiomyopathy refers to diseases of the heart muscle. These diseases have many causes, signs and symptoms, and treatments. The heart muscle becomes enlarged, thick or rigid in cardiomyopathy, and in rare cases the muscle tissue is replaced with scar tissue.
Causes of CM:
- Post- infarct (silent or not)
- Myocardial degeneration (old people)
Histology of CM:
- Myocyte atrophy
- Patchy interstital fibrosis
SUDDEN CARDIAC DEATH
Unexpected death due to heart problems, which occurs within one hour from the start of any cardiac-related symptoms. Due to massive transmural acute myocardial infarction or fatal arrhythmia [i.e. ventricular fibrillation, asystolia …]
ANGINA (Angor Pectoris)
Paroxysmal and usually recurrent attacks of subesternal or precordial chest discomfort (constricting, squeezing, choking …) caused by transient (15’’ to 15’) myocardial ischemia that falls short to induce cellular necrosis*.
- Cellular necrosis defines infarction from the pathological point of view.
STABLE ANGINA – is the most common type. Atheromatosis with luminal stenosis <50%. Subendocardial ischemia. ST depression.
PRINZMETAL OR VARIABLE ANGINA – due to spam in artery with severe atheromatosis (>50%), occurring at rest.
UNSTABLE OR CRESCENDO – progressively increasing frequency of the pain with less effort. Disruption of plaque with superimposed partial thrombosis.
ACUTE CORONARY SYNDROMES
The term acute coronary syndrome (ACS) refers to any group of clinical symptoms compatible with acute myocardial ischemia and includes unstable angina (UA), non—ST-segment elevation myocardial infarction (NSTEMI), and ST-segment elevation myocardial infarction (STEMI).