Mechanobiology and the Physical Stress Theory Flashcards
Ruffini end organs
aka joint angles Skin mechanoreceptors that signal to elongate tendon
Desmosomes (adhesions)
connections between adjacent cells
Gap Junctions
A way to communicate or allow for facilitated transport of substances from one cell to the next
Mechanotransduction
transduction of mechanical stimuli into a cellular signal response
integrin
proteins that span the membrane of the cell; have components inside and outside of the cell; can change shape
collagen fibers
gets signal form skin that is stretching
cell membrane
fibroblast cell membrane specifically
Stretch activated ion channels
can be opened or closed based on degree of stretch that cell membrane is exposed to
G coupled protein receptor and growth factor receptor proteins
Signals serve to modulate the response to mechanical stimuli
How is the signal Transduced?
transduction of signal from membrane to nucleus
transcription in nucleus
Transduction
activation of genes coding for collagen
transcription
DNA to RNA
How does the cell respond?
Translation by ribosomes
Processing by endoplasmic reticulum, Golgi
exocytosis of procollagen fibers
Extracellular processing and organization
Physical Stress Theory
States changes in the relative level of physical stress cause a predictable response in all biological tissue
physical stress
force applied to an area of tissue
