Mechanisms Of Disease Flashcards
Pathology
The study of disease
Signs
Objective abnormalities that can be seen or measured by someone other than the patient
Symptoms
The subjective abnormalities felt only by the patient
Syndrome
A collection of different signs and symptoms
- presents a distinct picture of a pathological condition
Acute
Signs and symptoms appear suddenly and persist for a short time, then disappear
Chronic
Disease that develops slowly and last for a long time
Subacute
A disease with characteristics of somewhere between acute and chronic
Etiology
Study of all factors involved in causing disease
Idiopathic
Undetermined cause of disease
Communicable or infectious
Disease that can be transmitted from one individual to another
Etiology
Refers to the theory of a diseases cause
Pathogenesis
The pattern of a diseased development
Latent
“Hidden”
Incubation
Latent stage
Convalescence
Recovery
Remission
Reversal of symptoms/ reversal of a chronic disease
Epidemiology
The study of the occurrence, distribution, and transmission of diseases in humans
Endemic
A disease that is native to a local region
Epidemic
A diseases that spreads to many individuals at the same time within a defined geographic region
Pandemics
Epidemics that spread throughout the world
Casual relationships
Establish the cause of a disease outbreak
Coincidental relationships
Events that coincide by chance
Morbidity
Information on disease rates in specific populations
Mortality
Numbers of deaths caused by specific diseases
Pathophysiology
The study of underlying physiological processes associated with disease
Genetic mutism
Altered or mutated genes that cause production of abnormal proteins
Infectious mechanism
Pathogenic organisms or particles that damage the body is some way
Parasite
An organism that lives in or on another organism to obtain its nutrients
Neoplasticism mechanism
Abnormal tissue growths that can cause a variety of physiological disturbances
Traumatic mechanism
Physical and chemical agents that can affect the normal homeostasis of the body
Metabolic mechanism
Endocrine imbalances or malnutrition that cause insufficient or imbalanced intake of nutrients
Degeneration
Breaking apart of tissues
Inflammatory mechanisms
Autoimmunity and inflammation
Autoimmunity
Faulty response or over reaction of the immune system that causes it to attack the body
Inflammation
Common response of the body to disturbances
Rick factors for diseases
Genetic factors (gene pool, inherited traits), age, lifestyle, stress, environmental factors, preexisting conditions
Microbes
Microscopic organisms
Viruses
Intercellular parasites that consist of a nuclear can acid core surrounded by a protein coat
Prions
Pathogenic protein molecules that convert normal proteins of the body into abnormal proteins
Bacterium
Tiny, primitive cell without a nucleus
Aerobic
Requiring oxygen for their metabolism
Anaerobic
Requiring an absence of oxygen
Ways to classify bacteria
Growth requirements, staining properties, shape and size
Bacilli (rods)
Bacterium:
Bacillus organisms, clostridium organisms, enterobacteria organisms, pseudomonas organisms
Cocci (spheres)
Bacterium:
Staphylococcus organisms, streptococcus organisms, neisseria organisms
Curved or spiral rod
Bacterium:
Vibrio organisms, campylobacter organisms, spirochetes
Small bacterium
Bacterium:
Rickettsia organisms, chlamydia organisms
Bacilli shape
Large, rod-shaped cells
Cocci shape
Large, round bacteria (found in pairs or strings)
Curved or spiral rods shapes
Curved rods arranged singly or in strands
Large curved or spiral cells arranged singly or in cell colonies
Small bacteria shapes
Round or oval (very very very tiny)
Spores
Bacteria can develop into resistant dormant state and grow again when conditions allow
Resistant to chemicals, heat, and dry, arid conditions
Archaea
Like bacteria but differ in their chemical makeup and metabolism. Thrive in harsh environments (none have been proven to cause disease yet)
Fungi
A group of simple organisms similar to plants but without chlorophyll
Yeasts
Small single celled fungi
Mold
Large multi cellular fungi
Protozoa
One celled organisms that are larger than bacteria and DNA is organized in the nucleus
Amoebas shape
Large cells of changing shape
Pseudopodia (false feet that move/ pull it around)
Flagellates shape
Similar to amoebas but move by wiggling along
Flagella (whiplike extensions)
Ciliates shape
Round
Cilia (short haired like projections that move it along)
Sporozoa shape
Unusual organelles at their tips that allow them to enter host cells (coccidia)
Amoeba
Entamoeba organisms:
Diarrhea, amebic dysentery, liver and lung infections
Flagellate
Giardia organisms:
Giardiasis, diarrhea, and malabsorption syndrome
Trichomonas organisms:
Trichomonas, vaginitis, urinary tract infections
Cillate
Balantidium organisms:
Gastrointestinal disturbances (pain, nausea, anorexia)
Sporozoan (coccidium)
Isospora organisms:
Isosporiasis infection of the gastrointestinal tract, diarrhea, and malabsorption syndrome
Plasmodium organisms:
Malaria
Toxoplasma organisms:
Toxoplamosis and congenital damage to fetus
Candida organisms
Classified as fungus
Thrush and mucous membranes infections (vaginal yeast infections)
Epidermophyton and microsporangia organisms
Classified as fungus
Tinea infections (ringworm, jock itch, athletes foot)
Histoplasma organisms
Classified as fungus
Histoplasmosis
Aspergillosis organisms
Classified as fungus
Aspergillosis and pneumonia
Coccidioides organisms
Classified as fungus
Coccidioidomycosis (San Joaquin fever)
Bacillus organisms
Classified as bacteria
Anthrax and gastroenteritis
Clostridium organisms
Classified as bacteria
Botulism, tetanus, and soft tissue infections
Enterobacteria organisms
Classified as a bacteria
Salmonella, diseases and gastroenteritis
Pseudomonas organisms
Classified as a bacteria
External otitis (swimmers ear), endocarditis, and pulmonary infections
Staphylococcus organisms
Classified as a bacteria
Staphylococci infections, food poisoning, urinary tract infections, toxic shock syndrome
Streptococcus organisms
Classified as a bacteria
Throat infections, pneumonia, sinusitis, otitis media, rheumatic fever, dental caries
Neisseria organisms
Classified as a bacteria
Meningitis, gonorrhea , pelvic inflammatory disease
Vibrio organisms
Classified as a bacteria
Cholera, gastroenteritis, wound infections
Campylobacter organisms
Classified as a bacteria
Diarrhea
Spirochetes
Classified as a bacteria
Syphilis, Lyme disease
Rickettsia organisms
Classified as a bacteria
Rocky Mountain spotted fever, Q fever
Chlamydia organisms
Classified as a bacteria
Genital infections, lymphograniloma, venereum, pelvic inflammatory disease, conjunctivitis, parrot fever
Metazoa
Pathogenic animals
Large multicellular organisms
Nematodes shape
Large parasites (roundworms)
Transmitted though food or flies that bite
Plathelminths shape
Large parasites (flatworms or flukes)
Arthropods shape
Group of parasites
Mites, ticks, lice, fleas
Boring and stunning wasps and bees, mosquitos, and spiders
Vector of disease
An organism that spreads disease to another organism
One to another
Nematode
Animal:
Ascaris organisms, enterobius organisms, trichinella organisms
Ascaris organisms
Classified as a Parasite
Intentional round worm, gastrointestinal obstruction, bronchial damage
Enterobius organisms
Classified as a parasite
Pinworm infestation of the lower gastrointestinal tract, itching around the anus, and insomnia
Trichnella organisms
Classified as a parasite
Trichinosis, fever, and muscle pain
Platyhelminth
Animal:
Schistosome organisms, fasciola organisms, taenia organisms
Schistosoma organisms
Classified as a parasite
Schistosomiasis (snail fever)
Fasciola organisms
Classified as a parasite
Liver fluke infestation
Taenia organisms
Classified as a parasite
Pork and beef tapeworm infestation
Arthropod
Animal:
Arachnids organisms, insecta
Arachnida organisms
Classified as a parasite
Infestation by mites and ticks, toxic bites by spiders, scorpions, and transmission of pathogens
Insecta
Classified as a parasite
Infestations of fleas, ticks, toxic bites by wasps, mosquitoes, and bees, and transmission of other pathogens
Aseptic technique
Killing of or disabling pathogens on surfaces before they can spread to other people
Sterilization
Destruction of all living organisms
Ex:
Pressured steam bath, extreme temperature, radiation used to sterilize surgical equipment
Disinfection
Destruction of most or all pathogens on inanimate objects but on necessarily all harmless microbes
Ex:
Chemicals such as iodine, chlorine, alcohol, phenol, and soaps
Antisepsis
Inhabitation or inactivation of pathogens
Ex:
Chemicals such as alcohol, iodine quaternary ammonium compounds, and dyes
Isolation
Separation of potentially infectious people or materials from non infected people
Ex:
Quarantine, protective apparel, disposal of bodily fluids, tissues, and other materials
Opportunistic invasion
Pathogenic organisms that don’t cause disease until they have the opportunity
Vaccine
Killed or weakened pathogen or part of a pathogen given to a person to stimulate immunity
Antibiotics
Compounds produced by certain living organisms or in a laboratory that kill inhibit pathogens
(Penicillin)
Bioterrorism
A pathogen that has been intentionally distributed to healthy victims
Inflammatory response
Combination of processes that attempt to minimize injury to tissues (maintain homeostasis)
Inflammatory response reasons
Mechanical injury:
Cuts, burns
Irritants:
Chemicals, radiation, toxins released by bacteria
Regeneration
Tissue repair, new cells are similar to those they replace
Replacement
New cells are different from those they replace
Like a scar
Fibrosis
Fibrous tissue replaced the old tissue
Signs of an inflammatory response
Redness, heat, swelling, and pain
Inflammation mediators
Histamine, prostaglandins and compounds such as kinins
Some mediators cause blood vessels to dilate (widen) to increase blood flow to the tissue
White blood cells
Help to fight infections or diseases
Edema
Water leaking out of a vessel causing tissue to swell
Inflammatory exudate
Fluid that accumulates in inflamed tissue
Chemotaxis
The movement of white blood cells in response to a chemical attractant
Pus
Thickened inflammatory exudate with white blood cells, dead tissue, and bacterial cells, and other bebris
Local
Confined to a point/ spot/ area of the body
Systemic
Entire body
Fever
Irritant or Inflamation of the body reset the internal “thermostat” to a higher temperature to kill or inhibit pathogenic microbes
Neoplasm
“New matter” refers to an abnormal growth of cells
Benign tumors
Remain localized within the tissue from which they arose
Malignant tumors
Tend to spread to other regions of the body
Benign tumor characteristics
Grows slow, is encapsulated in dense tissue, doesn’t expand to other tissues, similar to normal tissue cells, low mortality rate
Malignant tumor characteristics
Grows rapidly, not encapsulated, spreads to other tissues, abnormal to the tissues in your body, high mortality rate
Metastasis
Cells migrate through lymphatic or blood vessels
Papilloma
Benign tumor (epithelial tissues)
Forms finger like projections like a wart
Adenoma
Benign tumor (epithelial tissue)
Glandular epithelium
Nevus
Benign tumor (epithelial tissues)
Small pigmented tumors of the skin
Lipoma
Benign tumor (connective tissues)
From adipose tissue
Osteoma
Benign tumor (connective tissues)
Involves bone tissues
Chondroma
Benign tumor (connective tissues)
Cartilage tissues
Melanoma
Malignant tumor (epithelial tissues)
Involves melanocytes (skin)
Adenocarcinoma
Malignant tumors (epithelial tissues)
Glandular epithelium
Lymphoma
Malignant tumors (connective tissues)
Cancer of the lymphatic tissues
Osteosarcoma
Malignant tumor (connective tissues)
Tumor of bone tissue
Myeloma
Malignant tumor (connective tissues)
Bone marrow tumor
Fibrosarcoma
Malignant tumors (connective tissues)
Cancer of fiberous connective tissue
Adenofibroma
Benign neoplasm formed by epithelial and connective tissues
Neuroblastoma
Malignant tumor that arises from nerve tissue
Hyperplasia
A process that creates too many cells
Anaplasia
A process of creating Abnormal, undifferentiated tumor cells
Cachexia
Syndrome including loss of appetite, severe weight loss, and general weakness
Usually suffered by cancer patients