Mechanism of Psychotropic Drug Action Flashcards

1
Q

What % of the UK population take antidepressants?

A

7%

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2
Q

Describe the “positive” and negative” symptoms of Schizophrenia

A

Positive symptoms:
Occur during episodes, i.e. hallucinations, delusions, etc

Negative symptoms:
Occur and accumulate over time. Lack of motivation, reduced speech, emotion, withdrawal

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3
Q

Describe the pathophysiology of Bipolar disorder

A

Starts in young adult life, episodes of depression with manic episodes

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4
Q

Noradrenaline is particularly released by which set of neurons in the Brainstem?

A

Locus coerueus

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5
Q

Serotonin is particularly released by which set of neurons in the Brainstem?

A

Raphe Nuclei

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6
Q

Once a GABA receptor is stimulated, what ions flow across the post-synaptic membrane, causing hyperpolarisation?

A

Chloride, Cl-

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7
Q

Anti-psychotic drugs antagonist which receptors?

A

D2 (Dopamine) receptors

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8
Q

Give one example of a first generation D2 antagonising anti-psychotic drug

A

Haloperidol

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9
Q

Give two examples of a second generation D2 antagonising anti-psychotic drug

A

Olanzapine

Risperidone

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10
Q

What is the mechanism of action for Tricyclic Antidepressants?

A

Block noradreline uptake

Block serotonin uptake

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11
Q

What is the mechanism of action of Mono-amine oxidase inhibitors?

A

Block the action of MAO in nerve terminals, increasing NA, 5-HT, DA availability

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12
Q

What is the mechanism of action for Benzodiazepines?

A

Bind to a site on the GABA receptor, potentiating the effects of GABA ie. the GABA causes more Cl- flux and more inhibition

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