Mecanism of action Cardiotonic drugs

Question 1

Mecanism of action Cardiotonic drugs 1

Answer 1

Inhibition of Na+/K+ ATPase results in a small increase in intracellular sodium. The increased sodium alters the driving force for sodium-calcium exchange by the exchanger, NCX (Sodium-calcium exchanger), so that less calcium is removed from the cell.

Question 2

Mecanism of action Cardiotonic drugs 2

Answer 2

The increased intracellular calcium is stored in the sarcoplasmic reticulum and upon release increases contractile force.

Question 3

Mechanism Of Action of Cardiac glycosides(digoxin)

Answer 3

act by inhibiting sodium and potassium ATP and then making more calcium available to activate contracted proteins. & Cardiac contractility and cardiac output are increased.