Measles, Mumps and Rubella Viruses

Question 1

How is measles different from other paramyxoviridae?

Answer 1

lacks Neuraminidase. Has H protein rather than HN.
Forms intracellular inclusion bodies
Primary MV receptors are CD46 and SLAM

Question 2

What type of virus is measles virus?

Answer 2

paramyxo, non-segmented, negative RNA

Question 3

How are measles spread?

Answer 3

repiratory

Question 4

What is characteristic appearance of measles?

Answer 4

fever, cough, conjunctivitis, followed by characteristic maculopapular rash and Koplik spots

Question 5

Describe infection pattern of measles.

Answer 5

Initial viral replication in tracheal epithelium. Spred to lymph nodes. Characteristin lymphoid giant cells (Warthin Finkeldey cells). Then viremia.

Question 6

What is a serious effect of measles infection?

Answer 6

immunosuppression

Question 7

Where does mumps virus infect?

Answer 7

intially nasal mucosa and URT epithelium. spreads to lymphs.

Question 8

What are clinical signs of mumps?

Answer 8

first inflammation of parotid gland (chipmunking). Can progress to meningitis, deafness, gonadal swelling, diabetes, myocardial problems and fetal wastage.

Question 9

Describe rubella virus

Answer 9

enveloped, nonsegmented, +RNA virus

Question 10

What are the two types of rubella viruses? How are each transmitted?

Answer 10

alphavirus (by arthropods) and rubivirus (by humans only). both transmitted through aerosols

Question 11

Describe presentation of rubella infection.

Answer 11

low grade fever, conjunctivitis, sore throat, lymphadenopathy, morbilliform rash that starts on face and spreads to rest of body.

Question 12

How long is a person with rubella contagious?

Answer 12

for up to a month after initial exposure

Question 13

What is the most devastating effect of rubella?

Answer 13

destroys fetuses. This is why the vaccine was created. The disease is not that severe in adults or kids.

Question 14

What are primary receptors for measles virus?

Answer 14

CD46 and SLAM

Question 15

Which of these cause rash: Measles, Mumps, Rubella?

Answer 15

Measles and Rubella only

Question 16

What are Warthin-Finkdeldey cells are what are they indicative of?

Answer 16

reticuloendothelial syncytia that indicate measles infection in lymphoid tissue

Question 17

What is primary cell infected in blood during measles?

Answer 17

monocytes

Question 18

What are Koplik’s spots? What do they indicate?

Answer 18

small red spots with blue-white centers on inside of upper lip and cheek. Often seen before measles rash

Question 19

When is a person with mumps contagious?

Answer 19

as early as 6 days BEFORE clinical disease

Question 20

A male enters your clinic with gonadal enlargement of 3-4x normal size. Which of these does he likely have: Measles, Mumps or Rubella?

Answer 20

Mumps can cause testes to swell (orchitis)

Question 21

is Rubella + or - sense?

Answer 21

+RNA nonsegmented

Question 22

What was leading cause of aseptic meningitis prior to development of vacccine?

Answer 22

mumps