MDS

Question 1

What hematologic features are required to diagnose MDS?

Answer 1

1. Persistent cytopenia(s) with one or more cell lines that are below normal for 4 months without other causes
2. Myeloblasts with bone marrow blasts 5-19% or on peripheral smear 2-19%
3. MDS-defining cytogenetic/molecular features or dysplasia (>10% in one or more hematopoietic lineages) or ringed sideroblasts >15% (or >5% in the presence of SF3B1)

Question 2

Name two MDS-defining cytogenic/molecular abnormalities

Answer 2

1. Mutated SF3B1 (>10% VAF)
2. del(5q) with up to 1 additional cytogenetic abnormality (except 7/del (7q).

Question 3

What are the two classification systems for MDS?

Answer 3

1. International Consensus Classification (ICC)
2. World Health Organization 5 edition (WHO)