Cancer predisposition syndromes

Question 1

Lynch Syndrome

Lynch syndrome is a result of a germline mutation in one of four mismatch repair genes. What are the 4 genes?

Answer 1

MLH1
MSH2
MSH6
PMS2

Question 2

Lynch syndrome genetics

Mutations in MMR result in what genetic abnormality?

Answer 2

microsatellite instability (MSI-H)