HPV Flashcards
1
Q
Which HPV types are associated with head and neck cancer?
A
Types 16 and 18
2
Q
Which oncoproteins are associated with carcinogenesis?
A
E6 and E7
3
Q
E6
What is the function of E6?
A
promotes degradation of p53 which prevents apoptosis
4
Q
E7
What are the two functions of E7?
A
- promotes degradation of pRb which prevents apoptosis
- promotes transcription of p16
5
Q
association between HPV and p16
Is p16 expression synonymous with HPV infection?
A
No, p16 is a surrogate for HPV infection, but other cancers or environmental conditions can lead to increase in p16 expression, therefore p16 is NOT specific to HPV.
6
Q
HPV testing
What is considered the gold standard for confirming HPV infection?
A
HPV E6/E7 mRNA ISH (insitu hybridization)
