Lung Neuroendocrine Carcinoids

Question 1

Location

What is the typical location of a lung carcinoid?

Answer 1

75% are central

Question 2

Difference between typical carcinoid and atypical carcinoid

According to WHO criteria, how do you differentiate typical carcinoid from atypical carcinoid?

Answer 2

Note: only applicable in resected surgical specimens
Note: Ki-67 is not part of the WHO criteria
Answer: mitotic rate and presence of necrosis. If > 2 per 2 mm2 then atypical

however, typical carcinoids generally 1-5% Ki-67 and aytpical 5-20 to 30

Question 3

DIPNECH

What does DIPNECH stand for?

Answer 3

Diffuse idopathic pulmonary neuroendocrine cell hyperplasia

Typically this involved typical carcinoid

Radiographically, on CT has air trapping and thickening of the airways