MDS

Question 1

characterized by hypercellular maturation of _____,______,______

Answer 1

erythroid cells, granulocytes, megakaryocytes

Question 2

FEATURES:
1. occur primarily in persons over age ___
2. characterized by peripheral ______
3. characterized by ________ (abnormal dev’t maturation of wbc)
4. clinical course is shorter than ______ and longer than_____

Answer 2

1. 50
2. peripheral cytopenias
3. dysplasia of myeloid cell lines
4. Chronic Myeloproliferative Disorder; longer than Acute Leukemias

Question 3

MYELODYSPLASTIC/ MYELOPROLIFERATIVE DISORDERS characterized by variable increases in cells as well as ______ & morphological ______

Answer 3

cytopenia & morphological dysplasia

Question 4

MYELODYSPLASTIC/ MYELOPROLIFERATIVE DISORDERS

1. persistent monocytosis of > 1 X 109L for more than 3 mons
   - CMML-1: ___ in PB & ___ in BM
   - CMML-2: ___ in PB & ___ in BM
2. inc. those cases that meet the criteria for MDS/MPN but do not fit into one of the specified subcategories

Answer 4

1. Chronic Myelomonocytic Leukemia
   - <5% = PB, <10% = BM
   - 5% - 19% = PB, 10% - 19% = BM
2. Myelodysplastic/Myeloproliferative Disease, Unclassifiable

Question 5

MYELODYSPLASTIC/ MYELOPROLIFERATIVE DISORDERS

1. characterized by leukocytosis w/ prominent dysgranulopoiesis
   - _____ Negative
2. clonal disorder of predominantly granulocytic & monocytic lineages
   - previously referred as _____ or ____

Answer 5

1. Atypical Chronic Myeloid Leukemia
   - BCR-ABL1 Negative
2. Juvenile Myelomonocytic Leukemia
   - ‘ negative CML or Monosomy 7