Cmt

Question 1

_____: useful screening procedure for EXTRINSIC coagulation mechanism including the common pathway

1. monitors oral anticoagulant therapy w/ _____
2. facts with _____ to activate _____
3. reagents
   - combination of phospholipid & protein
   - substitute for calcium
4. RV
5. two source of error
   - prolonged
   - shorten
6. standardized way of reporting PT in monitoring oral anticoagulant therapy
   - Calibration Index

Answer 1

Prothrombin Time

1. COUMADIN
2. VII; X
   3.
   - Thromboplastin
   - 0.025M Calcium chloride
3. 10-12s
   5.
   - heparin contamination
   - traumatic phlebotomy
4. international normalized ratio
   - international sensitive index

Question 2

_____: for detection of factor X deficiency
- aka
1. uses venom from
2. prolonged factor ____
3. normal ______ since it is present in venom

Answer 2

Stypven Time
- Russel Viper Venom Test
1. Vipera russelli
2. X
3. VII

Question 3

TWO INDERECT TESTS DOR DETECTION OF FAVTOR 1

1. _____
   - RV
   - fibrinogen level is below
2. ____
   - RV
   - enzyme from

_____: INDERECT TEST FOR 13 DEFICIENCY
1. aka
2. Reagents (2)

Answer 3

TWO INDERECT TESTS DOR DETECTION OF FAVTOR 1

1. Thrombin Time
   - 17-25s
   - below 75-100mg/dL
2. Reptilase Test
   - 18-20s
   - Bothrops atrox snake

Dukert Test
1. 5M Urea Solubility Test
2. 5M urea, 1% monochloroacetic acid

Question 4

Historical Tests
1. performed on serum
- deficiency in factor (6)or platelets will slow the rate of prothrombin conversion
2. adsorbed plasma/ fresh serum
- by
- uses (2)
3. required recalcification of diluted plasma
- modification of _____

Answer 4

1. Prothrombin Consumption Tim
   - 5,8,9,10,11,12
2. Thromboplastin Generation Time
   - Biggs & Douglas
   - Barium Sulfate/ Aluminum Hydroxide
3. Hicks-Pitney Test
   - TGT

Question 5

Automation in Hemostasis

_____: stops assessing blood sample when there’s clot formation
1. uses _____ = semi-automated mechanical instrument
that detects fibrin strand formation using wire loop/hook

____: depends on the increase in light scattering
1. give 2 semi-automated instruments
2. give 2 automated instruments:

Answer 5

ELECTROMECHANICAL
1. Fibrinometer

PHOTO-OPTICAL
1. Electra 750 & 750A, Fibrintimer series
2. Coag-A-Mate X2 and XC;
MLA Electra 700 and 800

Question 6

_______: performed when APTT & PT are prolonged

1. to determine whether it is caused by (3)
2. if test DOES NOT REQUIRE (remains prolonged) when normal plasma:
3. if repeated test is CORRECTED when mixed w/ normal plasma:

Answer 6

Substitution Test/ Mixing Studies

1. NONSPECIFIC INHIBITOR; SPECIFIC FACTOR INHIBITOR; COAGULATION FACTOR DEFICIENCY
2. presence of pathological circulating anticoagulant
3. identification of deficient factor

Question 7

FACTORS ABSENT

1. Fresh Plasma
2. Aged/ Stored Plasma
3. Barium Sulfate Adsorbed Plasma

Answer 7

1. NONE
2. V, VIII
3. II, VII, IX, X

Question 8

FACTORS ABSENT

1. Fresh Serum
2. Aged/ Stored Serum
3. Adsorbed Serum

Answer 8

1. I, V, VIII, XIII
2. I, II, V, VIII, XIII
3. I, II, V, VII, VIII, IX, X, XIII