Fibrinolysis.2

Question 1

DISORDERS OF FIBRINOLYSIS
1. due to release of excessive activators of plasminogen resulting to conversion of
plasminogen to plasmin in the absence of fibrin formation
- ____ lysis
- treatment jnvolves _____ or ______
2. clot dissolution which results to increase FSP/ FDP that interfere w/ coagulation & platelet function
- _____ lysis

Answer 1

1. Primary Fibrinolysis
   - FIBRINOGEN
   - anti-fibrinolytic drugs/ antiplasmin
2. Secondary Fibrinolysis
   - FIBRIN

Question 2

INHERITED THROMBOTIC DISORDERS
1. recurrent venous thrombosis
- associated acquired condition
2. not associated w/ thrombosis
3. factor V Leiden is not inactivated —> excessive clot formation
4. increase in concentration of plasma prothrombin

Answer 2

1. Antithrombin Deficiency
   - DIC, liver disease, nephrotic syndrome,
   oral contraceptives, pregnancy
2. Heparin Cofactor II Deficiency
3. Activated Protein C Resistance
4. Prothrombin Mutations

Question 3

INHERITED THROMBOTIC DISORDERS
thromboembolism:
1. Protein C deficiency (5)
2. Protein S deficiency (3)

Answer 3

1. DIC, liver disease, Vit.K deficiency,
   malnutrition, warfarin therapy
2. DIC, liver diseases, Vit.K deficiency

Question 4

ACQUIRED THROMBOTIC DISORDERS
1. does not inhibit in vivo coagulation but may cause prolonged in vitro tests
- aka
2. development of antibodies against heparin-platelet factor 4 complex

Answer 4

1. Lupus Anticoagulant
   - Antiphospholipid Syndrome
2. Heparin-Induced Thrombocytopenia

Question 5

THERAPY:

_______: prevent platelet activation & aggregation
1. most effective in treatment of ______
2. _____ irreversibly affects platelet function by inhibiting cyclooxyrgenase (COX) enzyme
- formation of _______
3. other drugs (4)

Answer 5

ANTIPLATELET DRUGS
1. ARTERIAL DISEASES
2. Aspirin (Acetylsalicylic acid)
- thromboxane A2
3. dipyridamole, thienopyridines, ticlopidine, clopidogrel

Question 6

THERAPY:

_______: inhibit thrombin & fibrin formation
1.utilizes heparin
- anticoagulant activity of heparin is enhanced by binding to
- heparin dosage is monitored by ______ and __€_
2. utilizes COUMADIN, WARFARIN, DICUMAROL
- this crosses placenta present in human milk
- inhibits Vit k dependent factors (4)
- factors/proteins that are
formed
- dosage is monitored by ______ or ______

Answer 6

Anticoagulant Drugs

1. Intravenous Anticoagulant
   - Antithrombin
   - APTT & activated clotting time
2. Oral Anticoagulant
   - Coumadin (warfarin)
   - 2,7,9,10
   - des-γ-carboxy proteins
   - PT/ international normalized ratio

Question 7

THERAPY:

_______: to break down fibrin clots to restore vascular function and to prevent loss of tissues & organs
1. used in ______ for immediate thrombolytic
2. used in treatment of venous thromboembolism, myocardial infarction,
thrombolysis of clotted catheters
3. another enzyme

Answer 7

Thrombotic Drugs

1. arterial thrombosis
2. Urokinase
3. Streptokinase