MCTD Flashcards
MCTD is the prototypical overlap disease with features of lupus, scleroderma, and inflammatory myositis. This overlap is not seen at the outset of MCTD; rather it often takes several years to develop.
MCTD is most commonly associated with antibodies to what?
U1-RNP; in general this antibody predicts LACK of severe renal and central nervous system involvement.
T or F. 1.Raynaud’s phenomenon is seen in nearly all patients with MCTD
T; if Raynaud’s syndrome is absent, the diagnosis should be reconsidered.
How common is renal invovlemnt in MCTD? What type is most common?
About 25% of MCTD patients develop renal involvement—usually membranous glomerulonephritis. Proliferative glomerulonephritis is uncommon in MCTD.
More common in Lupus!
Most common nerve involvement in MCTD?
Serious CNS involvement is rare in MCTD; the commonest findings are trigeminal neuropathy and sensorineural hearing loss.
What is the commonest cause of death in MCTD patients?
PAH (listen for P2) or in a PFT look for isolated reduced DLCO
should be screened for on an ongoing basis.
What’s going on here?
Common EARLY finding of MCTD
The hand of a man with mixed connective tissue disease. The fingers have a generally puffy appearance with a fusiform proximal interphalangeal swelling of the third finger from an inflammatory arthritis. There is a periungual infarct at the nail fold of the third finger.
