Drug-Induced Lupus Flashcards
What environmental factors are definitely linked to increased risk of SLE?
-ultraviolet B light
What endogenous molecules are probably linked to increased risk of SLE?
estrogen and prolactin
What drugs are probably linked to increased risk of SLE?
- Hydralazine*
- Procainamide*
- Isoniazid*
- Hydrantoinds
- Chlorpromazine*
- Methyldopa
- TNFa inhibitors*
- Interferon A
- Penicillamine
- Minocycline
PITCH PIM PM
What viruses are probably linked to increased risk of SLE?
EBV
What dietary foods are probably linked to increased risk of SLE?
- Alfalfa sprouts (canavanine foods)
- vitamin D deficiency
Other things probably linked to increased risk of SLE?
- smoking
- human retroviruses
- bacterial DNA (causing anti-DNA Abs)
What drugs are currently (Sept 2016) Available for SLE?
- corticosteroids
- cyclophosphamide
- methotrexate
- mycophenolate mofetil
- Azathrioprine
- Hydroxychloroquine
- Belimumab
Presentation?
most common to least: arthralgia, arthritis, fever, and rash
no nephritis (unless TNFa antagonist drug induced)
Patient population for drug-induce lupus?
most commonly seen in young women being treated for acne
Pathogenesis
genetic susceptibility needed with a precipitating environmental and/or behavior trigger
What is Belimumab?
humanized monoclonal against BLYS (B-lymphocyte stimulator). Not that effective.
