Bone in Class Presentation Flashcards

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1
Q

Bone malignancies are fairly uncommon. What is one common?

A

liomyomas of the uterus (especially in AA women)

as well as lipomas

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2
Q

When you see mixed osteolytic and osteoblastic lesions in a female, think:

A

metastatic breast cancer

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3
Q

What patient population is common for osteosarcoma?

A

mostly children and some older than 60

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4
Q

A positive TTF-1 indicates what?

A

adenocarcinoma of the lung

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5
Q

GATA-3 is positive in what?

A

breast tumors and urothelial bladder tumors

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6
Q

What metastatic cancers to bone have blastic/sclerotic lesions (hyper dense-whiter)?

A

prostate (induce bone growth)

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7
Q

What metastatic cancers to bone have purely lytic lesions (blacker)?

A

kidney, thyroid, lung

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8
Q

Ewing’s sarcomas are almost always positive for what?

A

CD99 (not specific)

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9
Q

Other tests for Ewing’s sarcoma?

A

a FISH-based for 22q12 rearrangement and a PCR-based test for the discrimination of the Type 1 and Type 2 forms of the EWS-FLI1 translocations

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10
Q

Common situational cause of rickets?

A

mom has two children and the earlier born one doesnt get as much breast milk once the other is born

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11
Q

What is the defect in osteogenesis imperfecta?

A

type 1 collagen

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12
Q

Paget disease is a disease of _____

A

osteoclasts

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13
Q

Possible cause of Paget disease?

A

viral infection (paramyxovirus) in association with genetic susceptibility

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14
Q

What are the three phases of Paget disease?

A

1) lytic (incipient active)- dominated by osteoclast activity
2) mixed (active)- balanced osteoblast/clast activity
3) sclerotic/blastic (late inactive)

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15
Q

What are the serum markers for Paget disease?

A
  • elevated ALP
  • normal Ca2+ and phosphorus
  • urine hydroxyproline increased
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16
Q

How does primary syphilis present?

A

painless chancre

17
Q

How does secondary syphilis present?

A
  • palmar rash
  • LAD
  • condyloma latum
  • neurosyphilis (usually asymptomatic)
18
Q

Next step of syphilis?

A

latent

19
Q

What follows latent syphilis?

A

neurosyphilis, with aneurysms and gummas

20
Q

What are some potentials morbidities associated with congenital syphilis in infants?

A

rash, osteochondritis, periositis, and liver/lung fibrosis

21
Q

What are some potentials morbidities associated with congenital syphilis in childhood?

A
  • Interstitial keratitits
  • Hutchinson teeth
  • CN XIII deafness