MCP - Goodman - FA Synthesis - 2/24 Flashcards

1
Q

Where is pyruvate dehydrogenase found?

A

Only in the mitochondria

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2
Q

Can acetyl-CoA cross the mitochondrial membrane?

A

No, No, No

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3
Q

From what reaction is NADPH obtained for use in FA synthesis?

A

breakdown of OAA –> malate –> pyruvate+ NADPH

alternative method: pentose phosphate shunt

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4
Q

What is the rate-limiting/key regulatory enzyme in fatty acid synthesis?

A

Acetyl-CoA-carboxylase (ACC)

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5
Q

What is the function of fatty acid synthase?

A

To add 2 carbons to a growing FA chain, resulting eventually in palmitate

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6
Q

What enzymes are responsible for elongating fatty acid chains in the ER?

A

Elongases, with the normal: reduction-dehydration-reduction method

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7
Q

What are the 3 distinct kinds of desaturases?

A

delta9
delta6
delta5

common rxns are palmitic to palmitoleic
stearic to oleic (both are monounsaturated, delta9)

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8
Q

What roles do eiconsanoids play?

A

Inflammation
smooth muscle contraction
bronchoconstriction
bronchodilation

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9
Q

How do aspirin and NSAIDs work?

A

They inhibit prostaglandin synthesis at the arachidonic acid –> PGH2 pathway
Aspirin irreversibly inhibits COX-1 and COX-2 (enzymes) whereas acetominophen and ibuprofen are reversible inhibitors.

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