MCP - Goodman - FA Synthesis - 2/24 Flashcards
Where is pyruvate dehydrogenase found?
Only in the mitochondria
Can acetyl-CoA cross the mitochondrial membrane?
No, No, No
From what reaction is NADPH obtained for use in FA synthesis?
breakdown of OAA –> malate –> pyruvate+ NADPH
alternative method: pentose phosphate shunt
What is the rate-limiting/key regulatory enzyme in fatty acid synthesis?
Acetyl-CoA-carboxylase (ACC)
What is the function of fatty acid synthase?
To add 2 carbons to a growing FA chain, resulting eventually in palmitate
What enzymes are responsible for elongating fatty acid chains in the ER?
Elongases, with the normal: reduction-dehydration-reduction method
What are the 3 distinct kinds of desaturases?
delta9
delta6
delta5
common rxns are palmitic to palmitoleic
stearic to oleic (both are monounsaturated, delta9)
What roles do eiconsanoids play?
Inflammation
smooth muscle contraction
bronchoconstriction
bronchodilation
How do aspirin and NSAIDs work?
They inhibit prostaglandin synthesis at the arachidonic acid –> PGH2 pathway
Aspirin irreversibly inhibits COX-1 and COX-2 (enzymes) whereas acetominophen and ibuprofen are reversible inhibitors.