mcp: endocrine biphos

Question 1

bisphosphonates MOA

Answer 1

-Inhibit activity of osteoclasts, prevent further bone loss

Question 2

bisphosphonates adminstration

Answer 2

• Take immediately upon waking

- Take with 6-8 oz of plain water

Question 3

bisphosphonates administration, food

Answer 3

• Do not consume any food, beverages, or other medications after for at least:
• 30 minutes (alendronate, risedronate)
• 60 minutes (ibandronate)

Question 4

bisphosphonates administration, lying down?

Answer 4

• Remain upright and do not lie down for at least:
• 30 minutes (alendronate, risedronate)
• 60 minutes (ibandronate)

Question 5

bisphosphonates side effects

Answer 5

• GI tract irritation
• Musculoskeletal pain
• Hypocalcemia
• hypophosphatemia

Question 6

bisphosphonates drug interxn

Answer 6

• Oral NSAIDs

- Antacids, iron, multivitamins

Question 7

bisphosphonates precautions/warnings

Answer 7

• Osteonecrosis of the jaw (rare)
• Possible association between bisphosphonate use and atypical femur fracture (rare)
• Renal impairment
• Pre-existing GI irritation

Question 8

bisphosphonates guide?

Answer 8

FDA Medication Guide required

Question 9

bisphosphonates contraindications

Answer 9

-Abnormalities of esophagus which delay esophageal emptying
Inability to stand or sit upright for at least 30/60 min
-Hypocalcemia

-all must be resolved prior to initiating bisphosphonate therapy

Question 10

bisphosphonates time of effect

Answer 10

As early as 6-12 months after starting treatment

Question 11

when to get bone mineral density scan?

Answer 11

1-2 years after starting therapy

Every 2 years thereafter