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MCM Final Exam > MCM Final - Epithelium > Flashcards

MCM Final - Epithelium Flashcards

0
Q

endothelium

A

blood and lymph vessels

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1
Q

epithelium

A

tissues that line and cover body surfaces

avascular - no blood vessels

show cell polarity

progenitor cells present (dynamic)

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2
Q

mesothelium

A

lines serous cavities

ex./peritnoeum

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3
Q

glands

A

epithelial invaginations

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4
Q

simple epithelium

A

one cell layer

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5
Q

stratified epithelium

A

two or more cell layers

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6
Q

pseudostartified

A

all cells touch touch basal membrane, but not all reach surface

look stratified, but not

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7
Q

squamous epithelium

A

flattened cells

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8
Q

cuboidal epithelium

A

square cells

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9
Q

columnar epithelium

A

tall cells - 2x tall as wide

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10
Q

microvilli

A

specialization of the epithelium

increase absorptive area

actin filament core
-interact with terminal web in the cytoplasm

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11
Q

sterocilia

A

really long microvilli

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12
Q

striate border

A

microvilli

also brush border

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13
Q

cilia

A

specialization in the apical portion of epithelium

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14
Q

terminal web

A

network of microfilaments and intermediate filaments that support the apical structure microvilli

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15
Q

zona occludens

A

tight junctions

permeability seal and also establish functional domains
-separation of membrane portions

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16
Q

goblet cell

A

specialization in epithelium

secretes mucus

17
Q

keratinization

A

aka cornified

specialization of epithelium

also referred to as “dry” if keratinized (as opposed to wet)

18
Q

parakeratinized

A

specialized epithelial in oral cavity

cells are partially keratinized

19
Q

transitional epithelium

A

doesn’t follow normal classification system of epithelium

has the ability to stretch
-dome cells (umbrella cells) can stretch

ex./ urinary bladder

20
Q

epithelium in ducts?

A

stratified cuboidal

21
Q

zonula adherens

A

lateral epithelial structure

responsible for strength of cellular attachments
-resistance to shearing stress

utilizes E-cadherin

22
Q

dense plaques

A

in zonula adherens

myosin, tropomyosin, alpha-actinin, vinculin

23
Q

E-cadherin

A

utilized mainly in the zonula adherens but also present in the zona occluden

extracellular protein

24
Q

terminal bar

A

combination of zona occludens and zona adherens

25
Q

gap junctions

A

integral membrane proteins that allow for exchange between cells

formed from 6 connexin subunits (12 total - one on each cell’s membrane)

opening of pore due to adjacent connexins aligning

26
Q

connexin

A

subunit of gap junction

6 together form pore

27
Q

desmosome

A

links cell to cell

“spot weld” between cells - strong attachment

tonofilaments attach to cadherins that extend into extracellularly

desmoglein and desmocollin

28
Q

tonofilaments

A

tension fibers

in desmosomes - intermediate filaments that anchor the macula adherens

29
Q

the two cadherins in desmosomes?

A

desmoglein and desmocollin

30
Q

what cell layer has lots of desmosomes?

A

stratum spinosum layer of skin

-has “spines” which are points of desmosome attachment

31
Q

fascia adherens

A

similar to zonula adherens

form broad faced adhesion plate

- in intercalated disc of cardiac muscle
- adherens junctions stretch across terminal plate of cardiac muscle cell
32
Q

nexus

A

gap junction

33
Q

basement membrane - two parts?

A

basal lamina and reticular lamina

34
Q

reticular lamina

A

layer of underlying connective tissue in basement membrane

35
Q

basal lamina

A

immediately underlying cells in the basement membrane

36
Q

two layers of basal lamina?

A

lamina rara and lamina densa

37
Q

lamina rara

A

aka lamida lucida

laminin, entactin, and other PGs

38
Q

lamina densa

A

layer of basal lamina

collage IV, fibronectin, and perlecan

39
Q

collagen VII

A

anchoring fibrils that attach collagen to the lamina densa of the basal lamina

40
Q

hemidesmosome

A

connects cell to ECM

located on the basal cell surface of epithelium
-connect epithelium to underlying basement membrane

MCM Final Exam (16 decks)

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