MCF

Question 1

What is Malignant catarrhal fever (MCF)

Answer 1

• A sporadic, usually fatal, multisystemic viral disease of cattle, deer, bison, and certain exotic ruminants
• characterized in cattle by profuse mucopurulent nasal and ocular discharges, keratoconjunctivitis with corneal opacity, and enlargement of peripheral ln

Question 2

Taxonomy of MCFV?

Answer 2

• Family: Herpesviridae
• Subfamily: gammaherpesvirinae
• Genus: Macavirus

Question 3

What are the characteristics of MCFV?

Answer 3

• dsDNA genome
• Enveloped
• Icosahedral symmetry
• cause lymphoproliferative disease (gamma-herpesviruses)

Question 4

What are the subgroups of MCF and their hosts?

Answer 4

• OvHV-2 - sheep
• AIHV-1 - Wildebeest
• AIHV-2 - Hartebeest, topi
• CpHV-2 - Goat

Question 5

What is the history of MCF?

Answer 5

• Known in cattle in africa for centuries
• Sheep associated form occurs world-wide
• First reports of MCF-like disease in US cattle dates back to 1920s
• First bison case in US reported in 1873

Question 6

What species are affected by MCF?

Answer 6

• Domestic cattle
• American Bison
• Several species of Cervidae
• Buffalo
• Several wildlife ruminants

Question 7

How is MCF transmitted?

Answer 7

Question 8

How does MCF transmission occur in carrier species?

Answer 8

Question 9

How is MCF transmitted in susceptible species?

Answer 9

Question 10

What is the Incubation period, morbidity, mortality and duration of MCF?

Answer 10

Question 11

What is the pathogenesis of MCF

Answer 11

Question 12

WHat are the clinical signs of MCF

Answer 12

Question 13

What gross lesions are common to MCF

Answer 13

Question 14

What are the different forms of MCF?

Answer 14

Question 15

What happens in the peracute and Head and eye forms of MCF?

Answer 15

Question 16

What are the Intestinal and Mild forms of MCF like?

Answer 16

Question 17

How is MCF diagnosed?

Answer 17

Question 18

What serology tests are available for MCF

Answer 18

• Virus neutralization (VN)
• Immunobloting
• ELISA 9cELISA)
• IFA

Question 19

What samples should be taken for histopathology in MCF?

Answer 19

Question 20

What are common microscopic lesions with MCF?

Answer 20

Question 21

What is needed for PCR for MCF

Answer 21

Question 22

What is needed for Virus Isolation diagnosis of MCF?

Answer 22

Question 23

What are the differential dx for MCF in cattle?

Answer 23

Question 24

DDx for MCF in cervids?

Answer 24

Question 25

How can MCF (AIHV-1) be controlled?

Answer 25

Question 26

What are the important points of MCF

Answer 26

Question 27

Clinical definition of Rinderpest?

Answer 27

Question 28

Family and genus of Rinderpest?

Answer 28

Question 29

What is the relatedness of Morbilliviruses

Answer 29

Question 30

How long has Rinderpest been around?

Answer 30

Question 31

What are the recent events with Rinderpest

Answer 31

Question 32

How was Rinderpest eradicated

Answer 32

Question 33

What are the characteristics of the Rinderpest Viruse

Answer 33

Question 34

What are the characteristic of Rinderpest infection?

Answer 34

Question 35

How is Rinderpest transmitted?

Answer 35

Question 36

What animals host Rinderpest?

Answer 36

* Pigs * asiatic pigs are highly susceptible & spread the disease * European breeds develop mild transient virus * African & asian game: * Wide sprectrum of clinical disease * African buffalo, Giraffe & Kudu: very sensitive * Wild Asian buffalo: very severe

Question 37

What are the clinical stages of the Classic Form of Rinderpest?

Answer 37

* Incubation period = 4-5d (range of 3-15) * Febrile Period: 104-107F * Depression, anorexia, decreased rumination, increased respiratory & heart rate

Question 38

What are the post-mortem lesions seen with Rinderpest?

Answer 38

Question 39

What is Tiger/Zebra striping of Rinderpest?

Answer 39

Question 40

How is Rinderpest Diagnosed in the field? What samples should be taken for the lab? Where can the virus be isolated from?

Answer 40

Question 41

What are the diagnostic test options for Rinderpest?

Answer 41

Question 42

What are the differential diagnosis for Rinderpest

Answer 42

Question 43

How is Rinderpest prevented and Controlled?

Answer 43

Question 44

What is the vaccine for Rinderpest

Answer 44

Question 45

What are the important points of Riderpest?

Answer 45

Question 46

What is Bovine Papillomavirus?

Answer 46

Question 47

What is the pathogenesis for Bovine Papillomatiosis?

Answer 47

Question 48

How is Bovine Cutaneous papillomatosis dx?

Answer 48

Question 49

How is Bovine Cutaneous papillomatosis prevented/controlled?

Answer 49

Question 50

What is Bovine Ulcerative mammillitis?

Answer 50

Question 51

What is the pathogenesis for Bovine ulcerative mammillitis?

Answer 51

* Scab forms * Lesions heal 3-4 weeks * Nursing calves get lesions on the face and muzzle

Question 52

How is Bovine ulcerative Mammillitis diagnosed?

Answer 52

Question 53

How is Bovine ulcerative Mammillitis controlled?

Answer 53

Question 54

What is Cowpox & Bovine Vaccinia Mammillitis?

Answer 54

Question 55

What is the structure of Cowpox & Bovine Vaccinia Mammillitis?

Answer 55

Question 56

What is the pathogenesis of Cowpox & Bovine Vaccinia Mammillitis?

Answer 56

Question 57

How is Cowpox & Bovine Vaccinia Mammillitis diagnosed?

Answer 57

Question 58

What is Pseudo-cowpox (PCP)?

Answer 58

Cause regressing “ring” sores

Question 59

How is PCP diagnosed?

Answer 59

Question 60

What is Milkers Nodules?

Answer 60

Question 61

What is Bovine Papular Stomatitis (BPS)

Answer 61

Question 62

How is BPS diagnosed?

Answer 62