MBT (easy)

Question 1

Why must the RFLP allele be tightly linked to the gene locus of the disease allele?

Answer 1

1. Minimise the chance of CROSSING OVER

|&raquo_space; higher chance of being inherited together

Question 2

Why can RFLP markers be used?

Answer 2

1. Highly polymorphic&raquo_space; easily identifiable

2. Tightly linked to allele&raquo_space; crossing over is unlikely&raquo_space; inherited together as a unit