Mature Lymphoid Neoplasm

Question 1

is which the primary site of disease is the blood or bone marrow are classified as

Answer 1

leukemia

Question 2

is which the localization of disease is in the lymph nodes or spleen are classified as

Answer 2

lymphomas

Question 3

a disorder in which neoplastic cells are prominent in the blood yet also involve the spleen and lymph nodes

Answer 3

chronic lymphocytic leukemia

Question 4

a translocated gene that stimulates entry into the cell cycles

Answer 4

MYC

Question 5

a translocated gene suppresses apoptosis

Answer 5

BCL2

Question 6

a translocated gene which can suppress the transcription of other genes necessary for cell growth

Answer 6

BCL6

Question 7

it is the first step in interpreting patterns of involvement

Answer 7

examination of the morphology

Question 8

examples of aggressive disease

Answer 8

PAMBS

promyelocytic leukemia
adult t-cell leukemia/lymphoma
mantle cell lymphoma
burkitt leukemia/lymphoma
sezary syndrome

Question 9

examples of indolent disease

Answer 9

CLL
HCL
M
FL
W

Question 10

with a stem cell or precursor phenotype, is more commonly found in the pediatric population

Answer 10

acute lymphoid leukemia (ALL)

Question 11

symptoms of mature lymphoid neoplasm

Answer 11

fever
weight loss
night sweats
adenopathy

Question 12

in what disease does a patient complaints about alcohol intolerance or pruritus or skin rash upon starting ampicillin

Answer 12

hodgkin lymphoma

Question 13

it is the first test to order to investigate mature lymphoid neoplasm

Answer 13

complete blood count (CBC)

Question 14

B symptoms

Answer 14

weight loss (>10% body weight)
recurrent fever
recurrent drenching night sweats

Question 15

is often used to document clonality associated with lymphoid malignancies

Answer 15

flow cytometry

Question 16

have utility as estimates of tumor burden and have been incorporated into scoring systems that have prognostic value

Answer 16

LDH
B2 nicroglobulin

Question 17

it is the gold standard for lymphoma diagnosis

Answer 17

excisional biopsy

Question 18

was first applied to hodgkin lymphoma to quantify nodal and extranodal sites of involvement

Answer 18

ann arbor staging

Question 19

a simplification of the original ann arbor staging, and is currently used in NHL

Answer 19

lugano classification

Question 20

the most common leukemia in adults in western countries

Answer 20

chronic lymphocytic leukemia (CLL)

Question 21

median age of CLL

Answer 21

72 years old

Question 22

to establish as CLL it requires how many presence of circulating B lymphocytes

Answer 22

5x10^9/L

Question 23

the characteristic chromatin pattern of CLL

Answer 23

cobblestone or soccer ball

Question 24

common findings in PBS of CLL specimen

Answer 24

smudge lymphocytes

Question 25

B cell markers of CLL

Answer 25

CD19 CD20 CD23 T-cell antigen CD5

Question 26

a staging system that are based on clinical criteria that have prognostic implications for CLL

Answer 26

Rai and Binet staging system

Question 27

the transformation of chronic lymphocytic leukemia (CLL) into an aggressive lymphoma, most commonly diffuse large B-cell lymphoma (DLBCL).

Answer 27

richters transformation

Question 28

a disorder with 5x10^9/L B lymphocytes but are asymptomatic, without lymphadenopathy, organomegaly, cytopenias.

Answer 28

monoclonal B cell lymphocytosis (MBL)

Question 29

a disorder with 5x10^9/L B lymphocytes but with adenopathy, organomegaly

Answer 29

small lymphocytic lymphoma (SLL)

Question 30

a disorder with primary manifestations in the peripheral blood, bone marrow, spleen, splenomegaly, and lymphocytosis of 100x10^9/L

Answer 30

prolymphocytic leukemia (PLL)

Question 31

an indolent disease of B cell lineage most commonly found in middle age (50 years old)

Answer 31

hairy cell leukemia (HCL)

Question 32

a disorder does have cells that have round to ovoid nuclei, lack nucleoli, and have relatively abundant cytoplasm with ragged projections that extend around the entire cell

Answer 32

hairy cell leukemia (HCL)

Question 33

an antibody may help identify clusters of hairy cells

Answer 33

anti-CD20

Question 34

is specific to HCL and helps to differentiate HCL from related B cell disorders that have a similar morphology

Answer 34

annexin a

Question 35

markers of HCL

Answer 35

CD19 CD20 CD22 Annexin 1

Question 36

gene mutation associated with hairy cell leukemia

Answer 36

BRAF V600E

Question 37

this disorder has abundant, pale blue cytoplasm with distinct medium to large azurophilic cytoplasmic granules

Answer 37

large granular lymphocytic leukemia (LGL)

Question 38

large granular lymphocytic leukemia (LGL) markers

Answer 38

CD3 CD8 CD57

Question 39

a t cell disorder associated with retroviral infection by HTLV-1

Answer 39

adult t cell leukemia/lymphoma (ATLL)

Question 40

what cell morphology is observed in ATLL

Answer 40

flower cell

Question 41

markers present in ATLL

Answer 41

CD3 CD4 CD7 and CD8 is absent

Question 42

a soluble form that can be used as tumor marker of ATLL

Answer 42

IL-2

Question 43

an aggressive cancer of mature B cell associated with a fulminant clinical presentation

Answer 43

burkitt leukemia/lymphoma (BL)

Question 44

what are the subtypes of BL

Answer 44

endemic sporadic HIV associated

Question 45

this disorder have a morphology of cells that are medium to large in size, and deeply basophilic cytoplasm with distinct vacuoles

Answer 45

burkitt leukemia/lymphoma

Question 46

bone marrow and lymph node biopsy may show a classic starry sky

Answer 46

burkitt leukemia/lymphoma

Question 47

a neoplastic disorder of germinal b cells and accounts for approximately 12% of NHL cases

Answer 47

follicular lymphoma (FL)

Question 48

a disorder characterized by circulating FL cells have a condensed chromatin pattern and distinct nuclear cleft/cleavage

Answer 48

follicular lymphoma

Question 49

accurate diagnosis of MCL requires a demonstration of

Answer 49

t(11,14)

Question 50

it is associated with an infection with Helicobacter pylori

Answer 50

marginal zone lymphoma (MZL)

Question 51

nodal marginal zone lymphoma represents what morphology

Answer 51

waste paper basket

Question 52

is the most common familiar form of cutaneous t cell lymphoma

Answer 52

mycosis fungoides/sezary syndrome

Question 53

hodgkin lymphoma is associated with what cellular morphology

Answer 53

popcorn cells