Mature Lymphoid Neoplasm Flashcards
is which the primary site of disease is the blood or bone marrow are classified as
leukemia
is which the localization of disease is in the lymph nodes or spleen are classified as
lymphomas
a disorder in which neoplastic cells are prominent in the blood yet also involve the spleen and lymph nodes
chronic lymphocytic leukemia
a translocated gene that stimulates entry into the cell cycles
MYC
a translocated gene suppresses apoptosis
BCL2
a translocated gene which can suppress the transcription of other genes necessary for cell growth
BCL6
it is the first step in interpreting patterns of involvement
examination of the morphology
examples of aggressive disease
PAMBS
promyelocytic leukemia
adult t-cell leukemia/lymphoma
mantle cell lymphoma
burkitt leukemia/lymphoma
sezary syndrome
examples of indolent disease
CLL
HCL
M
FL
W
with a stem cell or precursor phenotype, is more commonly found in the pediatric population
acute lymphoid leukemia (ALL)
symptoms of mature lymphoid neoplasm
fever
weight loss
night sweats
adenopathy
in what disease does a patient complaints about alcohol intolerance or pruritus or skin rash upon starting ampicillin
hodgkin lymphoma
it is the first test to order to investigate mature lymphoid neoplasm
complete blood count (CBC)
B symptoms
weight loss (>10% body weight)
recurrent fever
recurrent drenching night sweats
is often used to document clonality associated with lymphoid malignancies
flow cytometry
have utility as estimates of tumor burden and have been incorporated into scoring systems that have prognostic value
LDH
B2 nicroglobulin
it is the gold standard for lymphoma diagnosis
excisional biopsy
was first applied to hodgkin lymphoma to quantify nodal and extranodal sites of involvement
ann arbor staging
a simplification of the original ann arbor staging, and is currently used in NHL
lugano classification
the most common leukemia in adults in western countries
chronic lymphocytic leukemia (CLL)
median age of CLL
72 years old
to establish as CLL it requires how many presence of circulating B lymphocytes
5x10^9/L
the characteristic chromatin pattern of CLL
cobblestone or soccer ball
common findings in PBS of CLL specimen
smudge lymphocytes
B cell markers of CLL
CD19
CD20
CD23
T-cell antigen CD5
a staging system that are based on clinical criteria that have prognostic implications for CLL
Rai and Binet staging system
the transformation of chronic lymphocytic leukemia (CLL) into an aggressive lymphoma, most commonly diffuse large B-cell lymphoma (DLBCL).
richters transformation
a disorder with 5x10^9/L B lymphocytes but are asymptomatic, without lymphadenopathy, organomegaly, cytopenias.
monoclonal B cell lymphocytosis (MBL)
a disorder with 5x10^9/L B lymphocytes but with adenopathy, organomegaly
small lymphocytic lymphoma (SLL)
a disorder with primary manifestations in the peripheral blood, bone marrow, spleen, splenomegaly, and lymphocytosis of 100x10^9/L
prolymphocytic leukemia (PLL)
an indolent disease of B cell lineage most commonly found in middle age (50 years old)
hairy cell leukemia (HCL)
a disorder does have cells that have round to ovoid nuclei, lack nucleoli, and have relatively abundant cytoplasm with ragged projections that extend around the entire cell
hairy cell leukemia (HCL)
an antibody may help identify clusters of hairy cells
anti-CD20
is specific to HCL and helps to differentiate HCL from related B cell disorders that have a similar morphology
annexin a
markers of HCL
CD19
CD20
CD22
Annexin 1
gene mutation associated with hairy cell leukemia
BRAF V600E
this disorder has abundant, pale blue cytoplasm with distinct medium to large azurophilic cytoplasmic granules
large granular lymphocytic leukemia (LGL)
large granular lymphocytic leukemia (LGL) markers
CD3
CD8
CD57
a t cell disorder associated with retroviral infection by HTLV-1
adult t cell leukemia/lymphoma (ATLL)
what cell morphology is observed in ATLL
flower cell
markers present in ATLL
CD3
CD4
CD7 and CD8 is absent
a soluble form that can be used as tumor marker of ATLL
IL-2
an aggressive cancer of mature B cell associated with a fulminant clinical presentation
burkitt leukemia/lymphoma (BL)
what are the subtypes of BL
endemic
sporadic
HIV associated
this disorder have a morphology of cells that are medium to large in size, and deeply basophilic cytoplasm with distinct vacuoles
burkitt leukemia/lymphoma
bone marrow and lymph node biopsy may show a classic starry sky
burkitt leukemia/lymphoma
a neoplastic disorder of germinal b cells and accounts for approximately 12% of NHL cases
follicular lymphoma (FL)
a disorder characterized by circulating FL cells have a condensed chromatin pattern and distinct nuclear cleft/cleavage
follicular lymphoma
accurate diagnosis of MCL requires a demonstration of
t(11,14)
it is associated with an infection with Helicobacter pylori
marginal zone lymphoma (MZL)
nodal marginal zone lymphoma represents what morphology
waste paper basket
is the most common familiar form of cutaneous t cell lymphoma
mycosis fungoides/sezary syndrome
hodgkin lymphoma is associated with what cellular morphology
popcorn cells
