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HEMATOLOGY > Mature Lymphoid Neoplasm > Flashcards

Mature Lymphoid Neoplasm Flashcards

1
Q

is which the primary site of disease is the blood or bone marrow are classified as

A

leukemia

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2
Q

is which the localization of disease is in the lymph nodes or spleen are classified as

A

lymphomas

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3
Q

a disorder in which neoplastic cells are prominent in the blood yet also involve the spleen and lymph nodes

A

chronic lymphocytic leukemia

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4
Q

a translocated gene that stimulates entry into the cell cycles

A

MYC

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5
Q

a translocated gene suppresses apoptosis

A

BCL2

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6
Q

a translocated gene which can suppress the transcription of other genes necessary for cell growth

A

BCL6

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7
Q

it is the first step in interpreting patterns of involvement

A

examination of the morphology

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8
Q

examples of aggressive disease

A

PAMBS

promyelocytic leukemia
adult t-cell leukemia/lymphoma
mantle cell lymphoma
burkitt leukemia/lymphoma
sezary syndrome

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9
Q

examples of indolent disease

A

CLL
HCL
M
FL
W

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10
Q

with a stem cell or precursor phenotype, is more commonly found in the pediatric population

A

acute lymphoid leukemia (ALL)

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11
Q

symptoms of mature lymphoid neoplasm

A

fever
weight loss
night sweats
adenopathy

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12
Q

in what disease does a patient complaints about alcohol intolerance or pruritus or skin rash upon starting ampicillin

A

hodgkin lymphoma

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13
Q

it is the first test to order to investigate mature lymphoid neoplasm

A

complete blood count (CBC)

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14
Q

B symptoms

A

weight loss (>10% body weight)
recurrent fever
recurrent drenching night sweats

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15
Q

is often used to document clonality associated with lymphoid malignancies

A

flow cytometry

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16
Q

have utility as estimates of tumor burden and have been incorporated into scoring systems that have prognostic value

A

LDH
B2 nicroglobulin

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17
Q

it is the gold standard for lymphoma diagnosis

A

excisional biopsy

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18
Q

was first applied to hodgkin lymphoma to quantify nodal and extranodal sites of involvement

A

ann arbor staging

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19
Q

a simplification of the original ann arbor staging, and is currently used in NHL

A

lugano classification

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20
Q

the most common leukemia in adults in western countries

A

chronic lymphocytic leukemia (CLL)

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21
Q

median age of CLL

A

72 years old

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22
Q

to establish as CLL it requires how many presence of circulating B lymphocytes

A

5x10^9/L

23
Q

the characteristic chromatin pattern of CLL

A

cobblestone or soccer ball

24
Q

common findings in PBS of CLL specimen

A

smudge lymphocytes

25
Q

B cell markers of CLL

A

CD19
CD20
CD23
T-cell antigen CD5

26
Q

a staging system that are based on clinical criteria that have prognostic implications for CLL

A

Rai and Binet staging system

27
Q

the transformation of chronic lymphocytic leukemia (CLL) into an aggressive lymphoma, most commonly diffuse large B-cell lymphoma (DLBCL).

A

richters transformation

28
Q

a disorder with 5x10^9/L B lymphocytes but are asymptomatic, without lymphadenopathy, organomegaly, cytopenias.

A

monoclonal B cell lymphocytosis (MBL)

29
Q

a disorder with 5x10^9/L B lymphocytes but with adenopathy, organomegaly

A

small lymphocytic lymphoma (SLL)

30
Q

a disorder with primary manifestations in the peripheral blood, bone marrow, spleen, splenomegaly, and lymphocytosis of 100x10^9/L

A

prolymphocytic leukemia (PLL)

31
Q

an indolent disease of B cell lineage most commonly found in middle age (50 years old)

A

hairy cell leukemia (HCL)

32
Q

a disorder does have cells that have round to ovoid nuclei, lack nucleoli, and have relatively abundant cytoplasm with ragged projections that extend around the entire cell

A

hairy cell leukemia (HCL)

33
Q

an antibody may help identify clusters of hairy cells

A

anti-CD20

34
Q

is specific to HCL and helps to differentiate HCL from related B cell disorders that have a similar morphology

A

annexin a

35
Q

markers of HCL

A

CD19
CD20
CD22
Annexin 1

36
Q

gene mutation associated with hairy cell leukemia

A

BRAF V600E

37
Q

this disorder has abundant, pale blue cytoplasm with distinct medium to large azurophilic cytoplasmic granules

A

large granular lymphocytic leukemia (LGL)

38
Q

large granular lymphocytic leukemia (LGL) markers

A

CD3
CD8
CD57

39
Q

a t cell disorder associated with retroviral infection by HTLV-1

A

adult t cell leukemia/lymphoma (ATLL)

40
Q

what cell morphology is observed in ATLL

A

flower cell

41
Q

markers present in ATLL

A

CD3
CD4
CD7 and CD8 is absent

42
Q

a soluble form that can be used as tumor marker of ATLL

A

IL-2

43
Q

an aggressive cancer of mature B cell associated with a fulminant clinical presentation

A

burkitt leukemia/lymphoma (BL)

44
Q

what are the subtypes of BL

A

endemic
sporadic
HIV associated

45
Q

this disorder have a morphology of cells that are medium to large in size, and deeply basophilic cytoplasm with distinct vacuoles

A

burkitt leukemia/lymphoma

46
Q

bone marrow and lymph node biopsy may show a classic starry sky

A

burkitt leukemia/lymphoma

47
Q

a neoplastic disorder of germinal b cells and accounts for approximately 12% of NHL cases

A

follicular lymphoma (FL)

48
Q

a disorder characterized by circulating FL cells have a condensed chromatin pattern and distinct nuclear cleft/cleavage

A

follicular lymphoma

49
Q

accurate diagnosis of MCL requires a demonstration of

A

t(11,14)

50
Q

it is associated with an infection with Helicobacter pylori

A

marginal zone lymphoma (MZL)

51
Q

nodal marginal zone lymphoma represents what morphology

A

waste paper basket

52
Q

is the most common familiar form of cutaneous t cell lymphoma

A

mycosis fungoides/sezary syndrome

53
Q

hodgkin lymphoma is associated with what cellular morphology

A

popcorn cells

HEMATOLOGY (7 decks)

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