Maternal Behaviour Flashcards
What are the two different types of nursing behaviour?
Low crouch and high crouch
How does more licking and grooming correlate to stress resistance?
More glucocorticoid receptors in the hippocampus
What is phenotypic plasticity?
The ability to change phenotypes according to environmental cues
How is the number of glucocorticoid receptors regulated?
more serotonin in the hippocampus; serotonin receptor activated; cAMP increase; PKA increases; PKA phosphorylates NGFI-a; NGFI-a activates nuclear transcription for glucocorticoid receptors
What is NGFI-a?
Transcription factor for glucocorticoid receptors
What is PKA?
Protein kinase A
What is epigenetics?
Changes in gene expression that are not caused by alterations in the DNA sequence
How are the sites responsible for methylation in NGFI-a called?
CpG sites
How is CpG methylation called?
Epigenome
How do you turn transcription in NGFI off?
Methylation of cytosines in CpG sites by DNA methyltransferase
What is the name of the method used to see methylation?
Sodium Bisulfide sequencing
What does sodium bisulfide sequencing change?
All the unmenthylated cytosines into uracils
What is the name of the drug that demethylates DNA?
trichostatin A (TSA)
What makes daughters of high LG mothers become high LG mothers themselves?
High amount of estrogen receptors in the medial preoptic area of the hypothalamus (MPOA)
