Learning and memory Flashcards
How do you achieve habituation?
With repetitive weak stimuli the reflex stops
How do you achieve Hypersensitization?
Alarmant stimulus, longer and stronger effects
Who does the interneuron make synapses with and what does it secrete
With sensory neuron and motor neuron; serotonin
What is the molecular mechanism for synapse strenghtening?
GPCR activation transcription in CREB
What type of maze is used for classical conditioning in Drosophla?
T-maze
What is the name of mutants who cannot learn?
Dunce
What protein does the dunce mutant affect?
Stop hydrolization of cAMP, phosphodiesterase
What does rutabaga affect?
calcium-calmodulin- responsive adenylyl-cyclase (ATP to cAMP)
What does dCREB2 do?
inhibitor of CREB that stops long term memory
How is the integration center of the memory in flies called?
Mushroom body
What genes are expressed in the mushroom body?
Dunce and rutabaga
What are the two components of the mushroom body?
The gamma lobe and the alpha lobe
What is expressed in the gamma lobe?
Dunce and rutabaga
How can you track dopamine neurons?
By lookinf for tyrosine hydroxylase
