Mast Cell Tumors Flashcards
What is the significance of Ki67 staining for MCT?
> 1.8% indicates poor px regardless of grade
What breed is predisposed to higher grade MCT?
Shar-pei
Name contents of mast cell granules (7)
Histamine Heparin Serotonin Proteolytic enzymes Cytokines Leukotrienes Eosinophil chemotactic factor
In a study of pulse-dosed toceranib combined with lomustine for unresectable MCT, what was the dose-limiting toxicity?
neutropenia
17% grade 3
22% grade 4
In a study of pulse-dosed toceranib combined with lomustine for unresectable MCT, what was the ORR?
Was the c-kit mutation associated with response?
46%
c-kit mutation not associated with response to tx
In a study of pulse-dosed toceranib combined with lomustine for unresectable MCT, what was the PFS?
What was the median OS?
53 days PFS (range 1 to >752)
131 days OS (range 4 to >752)
What % of dogs with MCT experience a CR with Palladia?
14%
London, C. A., et al. (2009). “Multi-center, placebo-controlled, double-blind, randomized study of oral toceranib phosphate (SU11654), a receptor tyrosine kinase inhibitor, for the treatment of dogs with recurrent (either local or distant) mast cell tumor following surgical excision.” Clinical Cancer Research 15(11): 3856-3865.
What is the reported ORR of MCT to single agent lomustine?
23%
What is the dose-limiting toxicity for pulse-administered toceranib phosphate combined with CCNU?
a. gastrointestinal ileus b. thrombocytopenia c. hematuria d. hepatotoxicity e. neutropenia
E - neutropenia
Burton, J. H., et al. “Pulse‐Administered Toceranib Phosphate Plus Lomustine for Treatment of Unresectable Mast Cell Tumors in Dogs.” Journal of Veterinary Internal Medicine 29.4 (2015): 1098-1104.
