Mannitol

Question 1

Brand name of Mannitol

Answer 1

Osmitrol

Question 2

Drug class of Mannitol

Answer 2

Osmotic diuretic

Question 3

Mannitol’s mechanism of action

Answer 3

Promotes the movement of fluid from the intracellular space to the extracellular space. Decreases cerebral edema and intracranial pressure. Promotes urinary excretion of toxins.

Question 4

Indications for Mannitol

Answer 4

Cerebral edema, reduce intracranial pressure (ICP) for certain cause (space-occupying lesions), rhabdomyolysis (myoglobinuria), blood transfusion reaction.

Question 5

Contraindications for Mannitol

Answer 5

Hypotension, Pulmonary Edema, Severe dehydration, Congestive heart failure active intracranial bleeding

Question 6

Adverse effects of Mannitol

Answer 6

Headache, confusion, seizures, pulmonary
Edema, tachycardia, chest pain CHF,
Hypotension, N/V, dehydration.

Question 7

Precautions for Mannitol

Answer 7

May precipitate digitalis toxicity

Question 8

Adult Dose and admin of Mannitol via IVP

Answer 8

0.5 – 1 g/kg IV infusion over 5 – 10 minutes. Additional doses of 0.25 – 2 g/kg can be given every 4 – 6 hours PRN.

Question 9

Pediatric Dose and admin of Mannitol via IVP/IO

Answer 9

0.5 – 1 g/kg/dose IV/IO infusion over 30-60 minutes, may repeat in 30 minutes.